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Xalkori

Xalkori

(crizotinib)

Xalkori (Crizotinib) belongs to the group of cancer-fighting medications known as antineoplastics and more specifically to a class of medications called tyrosine kinase inhibitors. These medications slow the growth of blood vessels that feed nutrients to cancer cells.

Available form

Dosage

Capsule

200MG

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Xalkori information

Dosage

Side Effects

Available Form

Contraindications

Precautions

Warnings

The usual recommended dose of Xalkori (Crizotinib) is 250 mg taken by mouth 2 times daily. Your doctor may adjust your dose depending on how you tolerate Xalkori (Crizotinib). Swallow the capsules whole – do not crush, dissolve, or open the capsules. Xalkori (Crizotinib) can be taken with or without food. Do not take Xalkori (Crizotinib) with grapefruit, starfruit, pomegranate, Seville oranges, or other similar fruits, since they may interact with Xalkori (Crizotinib).

Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.

It is important that Xalkori (Crizotinib) be taken exactly as prescribed by your doctor. If you miss a dose, take it as soon as you remember. If it is less than 6 hours until the next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

Store Xalkori (Crizotinib) at room temperature (between 15°C and 30°C) and keep it out of the reach of children. Do not touch a crushed or broken capsule.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.

The side effects listed below are not experienced by everyone who takes Xalkori (Crizotinib). If you are concerned about side effects, discuss the risks and benefits of Xalkori (Crizotinib) with your doctor.

The following side effects have been reported by at least 1% of people taking Xalkori (Crizotinib). Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

back or joint pain
change of taste
Constipation
cough
decreased appetite
Diarrhea
dizziness
headache
mouth ulcers
nausea
rash
shortness of breath
swelling of the hands and feet
symptoms of Neuropathy (e.g., numbness, prickling or tingling, burning, freezing, throbbing or shooting pain)
tiredness
trouble sleeping
upset stomach
vomiting

Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not check with your doctor or seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

chest pain
Fever
heart rhythm abnormality (e.g., dizziness, fainting, or chest discomfort)
Low Blood Pressure
more frequent infections (symptoms may include fever or chills, severe diarrhea, shortness of breath, prolonged dizziness, headache, stiff neck, weight loss, sinus pain, sore throat, losing voice, or listlessness)
slow heart rate
signs of Anemia (low red blood cells; e.g., dizziness, pale skin, unusual tiredness or weakness, shortness of breath)
symptoms of kidney problems (e.g., pain in the back or side, blood in the urine)
symptoms of lung infection (e.g., fever, chills, shortness of breath, cough)
symptoms of liver problems (e.g., feeling more tired than usual, decreased appetite, yellowing of the skin or whites of the eyes, stomach pain, dark urine, nausea, vomiting, itching, or bleeding or bruising more easily than normal)
symptoms of lung infection or inflammation (e.g., difficulty breathing, cough, or fever)
vision changes (e.g., blurred vision, flashes of light, double vision)

Stop taking the medication and seek immediate medical attention if any of the following occur:

partial or complete loss of vision in one or both eyes
signs of a serious allergic reaction (e.g., swelling of face or throat, Hives, or difficulty breathing)

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking Xalkori (Crizotinib).

Before you begin using a medication, be sure to inform your doctor of any medical conditions or Allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use Xalkori (Crizotinib).

Abnormal heart rhythms: Xalkori (Crizotinib) can cause abnormal heart rhythms. Certain medications (e.g., Sotalol, quinidine, thioridazine, Chlorpromazine, , Pimozide, moxifloxacin, Mefloquine, pentamidine, arsenic trioxide, probucol, Tacrolimus) can increase the risk of a type of abnormal heart rhythm called QT prolongation, and should not be used in combination with Xalkori (Crizotinib). You are more at risk for this type of abnormal heart rhythm and its complications if you:

are female
are older than 65 years of age
have a family history of sudden cardiac death
have a history of heart disease or abnormal heart rhythms
have a slow heart rate
have congenital prolongation of the QT interval
have Diabetes
have had a Stroke
have low potassium, magnesium, or calcium levels
have nutritional deficiencies

If you have heart disease and abnormal heart rhythms, or are taking certain medications (e.g., Verapamil, atazanavir), discuss with your doctor how Xalkori (Crizotinib) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Xalkori (Crizotinib), and whether any special monitoring is needed.

Blood Clots: Xalkori (Crizotinib) may cause formation of blood clots in the legs (deep vein thrombosis) that can move to the lungs (pulmonary Embolism). Blood clots can also cause a Heart Attack or a stroke. Contact your doctor as soon as possible if you have pain, redness, or swelling in your legs. If you develop chest pain and shortness of breath, seek immediate medical attention. Also seek immediate medical attention if you have sudden headache, dizziness, problems speaking, vision problems, or numbness or weakness, even if they are temporary. If you have had a blood clot in the past, discuss with your doctor how Xalkori (Crizotinib) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Xalkori (Crizotinib), and whether any special monitoring is needed.

Eye problems: You may experience vision disturbances such as flashes of light, blurry vision, and double vision. Tell your doctor if you experience any of these symptoms. Do not drive or operate other machinery until you know that Xalkori (Crizotinib) does not affect your ability to perform these activities safely. There have been rare repots of vison loss in patients taking Xalkori (Crizotinib). If you notice any vision loss in one or both eyes, contact your doctor immediately.

Fatigue and dizziness: Xalkori (Crizotinib) can cause fatigue and dizziness. Do not drive or operate machinery until you know that Xalkori (Crizotinib) does not affect your ability to perform these activities safely.

Heart problems: Xalkori (Crizotinib) can slow heart rate and decrease blood pressure. It can also decrease heart function, which may lead to heart failure or worsen symptoms of heart disease. If you have heart disease such as Angina, Congestive Heart Failure, or arrhythmia, discuss with your doctor how Xalkori (Crizotinib) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Xalkori (Crizotinib), and whether any special monitoring is needed. If you experience symptoms of heart failure such as unusual tiredness, shortness of breath, or swelling of the feet and ankles, contact your doctor.

Kidney problems: If you have severe kidney problems, discuss with your doctor how Xalkori (Crizotinib) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Xalkori (Crizotinib), and whether any special monitoring is needed.

Liver function: Xalkori (Crizotinib) may reduce liver function and can cause liver problems that can be severe. Your doctor will monitor your liver function with blood tests while you are taking Xalkori (Crizotinib). If you have liver problems, discuss with your doctor how Xalkori (Crizotinib) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Xalkori (Crizotinib), and whether any special monitoring is needed.

If you experience symptoms of liver problems such as fatigue, feeling unwell, loss of appetite, nausea, yellowing of the skin or whites of the eyes, dark urine, pale stools, abdominal pain or swelling, and itchy skin, contact your doctor immediately.

Lung inflammation: Lung inflammation (interstitial lung disease), causing difficulty breathing has occurred rarely in some people taking Xalkori (Crizotinib). This complication can be serious and sometimes fatal. If you experience new or worsening shortness of breath or cough (with or without fever) at any time while you are taking Xalkori (Crizotinib), contact your doctor immediately.

Nerve problems: People taking Xalkori (Crizotinib) may experience symptoms of neuropathy (nerve damage) such as numbness, prickling or tingling, burning, freezing, and throbbing or shooting pain. Tell your doctor if you experience any of these symptoms.

Pregnancy: Xalkori (Crizotinib) should not be used during pregnancy. Both men and women should use effective birth control (e.g., condoms, birth control pill) during treatment and for at least 90 days after treatment is finished. If you or your partner become pregnant while taking Xalkori (Crizotinib), contact your doctor immediately.

Male and female fertility may be affected by treatment with crizotinb. Discuss any concerns you have with your doctor.

Breast-feeding: It is not known if Xalkori (Crizotinib) passes into breast milk. If you are a breast-feeding mother and are taking Xalkori (Crizotinib), it may affect your baby. Due to the potential for serious harm to a baby if they are exposed to Xalkori (Crizotinib), breast-feeding mothers are advised not use Xalkori (Crizotinib). Talk to your doctor about whether you should continue breast-feeding.

Children: The safety and effectiveness of using Xalkori (Crizotinib) have not been established for children less than 18 years of age.

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