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Dantrium

Dantrium

(dantrolene)

Dantrium (Dantrolene) belongs to a group of medications known as muscle relaxants. Dantrium (Dantrolene) capsules are used to treat people with chronic muscle spasms caused by conditions such as cerebral palsy, Multiple Sclerosis, Stroke, or spinal cord injury.

Available form

Dosage

Injectable Powder

20MG

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Dantrium information

Dosage

Side Effects

Available Form

Contraindications

Precautions

Warnings

The usual starting dose for adults is 25 mg once daily. The dose is then increased gradually until the best dose is found, based on individual response and needs. The best dose is the lowest dose that will control muscle spasms. Most people respond to doses of 400 mg daily (given in divided doses, usually as 100 mg 4 times daily) or less.

Children's dosing is based on body weight. Children should not be given doses higher than 100 mg 4 times daily.

The dose for the injectable form of Dantrium (Dantrolene) is based on body weight.

Many things can affect the dose of a medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are using the medication without consulting your doctor.

It is important to use Dantrium (Dantrolene) exactly as prescribed by your doctor. If you miss a dose, administer it as soon as possible and continue with your regular schedule. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not administer a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

Store Dantrium (Dantrolene) at room temperature, protect it from light and moisture, and keep it out of the reach of children.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent. The side effects listed below are not experienced by everyone who takes Dantrium (Dantrolene). If you are concerned about side effects, discuss the risks and benefits of Dantrium (Dantrolene) with your doctor.

The following side effects have been reported by at least 1% of people taking Dantrium (Dantrolene). Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

abdominal or stomach cramps or discomfort
chills and Fever
Diarrhea
difficulty swallowing
dizziness
drowsiness
frequent urge to urinate or uncontrolled urination
general feeling of discomfort or illness
headache
loss of appetite
muscle weakness
nausea or vomiting
skin rash
sweating
unusual tiredness

Although most of these side effects listed below don't happen very often, they could lead to serious problems if you do not check with your doctor or seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

confusion
Constipation
signs of Depression (e.g., poor concentration, changes in weight, changes in sleep, decreased interest in activities, thoughts of suicide)
symptoms of liver damage (e.g., yellow skin or eyes, abdominal pain, dark urine, clay-coloured stools, loss of appetite)
worsening symptoms of heart failure (e.g., difficulty breathing, rapid weight gain, swollen ankles or feet)

Stop taking the medication and seek immediate medical attention if any of the following occur:

chest pain
convulsions (seizures)
fast or pounding heartbeat
pain, tenderness, changes in skin colour, or swelling of foot or leg
shortness of breath or slow or troubled breathing

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking Dantrium (Dantrolene).

There may be an interaction between Dantrium (Dantrolene) and any of the following:

alcohol
antihistamines (e.g., cetirizine, doxylamine, Diphenhydramine, Hydroxyzine, Loratadine)
antipsychotics (e.g., Chlorpromazine, Clozapine, Haloperidol, Olanzapine, Quetiapine, Risperidone)
Apalutamide
benzodiazepines (e.g., Alprazolam, Diazepam, Lorazepam)
Bosentan
brimonidine
Buspirone
calcium channel blockers (e.g., Amlodipine, Diltiazem, Verapamil)
cannabis
chloral hydrate
Dabrafenib
Deferasirox
Dexamethasone
efavirenz
Enzalutamide
estrogens (e.g., conjugated estrogen, Estradiol, ethinyl estradiol)
etravirine
Methadone
Mirtazapine
Mitotane
Modafinil
muscle relaxants (e.g., Baclofen, Cyclobenzaprine, methocarbamol, orphenadrine)
Nabilone
narcotic pain relievers (e.g., Codeine, Fentanyl, Morphine, Oxycodone)
Pramipexole
rifabutin
rifampin
Ropinirole
Rotigotine
St. John's wort
scopolamine
seizure medications (e.g., Carbamazepine, Clobazam, Levetiracetam, Phenobarbital, Phenytoin, primidone, Topiramate, Valproic acid, zonisamide)
selective serotonin reuptake inhibitors (SSRIs; e.g., Citalopram, Fluoxetine, Paroxetine, Sertraline)
siltuximab
sodium oxybate
Tapentadol
thalidomide
Tocilizumab
Tramadol
tricyclic antidepressants (e.g., Clomipramine, Desipramine, Imipramine)
Zolpidem
Zopiclone

If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

stop taking one of the medications,
change one of the medications to another,
change how you are taking one or both of the medications, or
leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with Dantrium (Dantrolene). Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the Nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.

Before you begin using a medication, be sure to inform your doctor of any medical conditions or Allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use Dantrium (Dantrolene).

Cancer: The potential for Dantrium (Dantrolene) to cause cancer in humans cannot be ruled out. If you have any questions or concerns, talk to your doctor.

Drowsiness/reduced alertness: Dantrium (Dantrolene) may temporarily cause drowsiness, which may impair your ability to drive or operate machinery. These effects should only last about a week. Avoid hazardous tasks for the first week of treatment.

Heart function: If you have heart disease, you should be monitored closely by your doctor while taking Dantrium (Dantrolene).

Liver injury: Dantrium (Dantrolene) capsules may be toxic to the liver, or worsen existing liver damage. The risk of liver injury is greater for women, people over 30 years old, people taking other medications, and people taking other therapies that may cause liver damage. If you experience symptoms of liver problems such as fatigue, feeling unwell, loss of appetite, nausea, yellowing of the skin or whites of the eyes, dark urine, pale stools, abdominal pain or swelling, and itchy skin, contact your doctor immediately.

If you have liver disease, talk to your doctor about whether you should use Dantrium (Dantrolene). People using Dantrium (Dantrolene) will likely have liver tests before and during use.

Lung function: If you have impaired lung function, you should be monitored closely by your doctor while taking Dantrium (Dantrolene)

Muscle weakness: Some people taking Dantrium (Dantrolene) feel excessively weak as long as they are taking the medication. These people may not be able to use rehabilitation devices such as crutches, wheelchairs, braces, walkers, or canes. If you use any of these devices and experience persistent weakness that interferes with the use of these devices, you should talk to your doctor. You may have to stop taking Dantrium (Dantrolene).

Pregnancy: Dantrium (Dantrolene) should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking Dantrium (Dantrolene), contact your doctor immediately.

Breast-feeding: Dantrium (Dantrolene) passes into breast milk. If you are a breast-feeding mother and are taking Dantrium (Dantrolene), it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.

Children: The safety and effectiveness of using Dantrium (Dantrolene) have not been established for children under 5 years old.

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