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Onglyza

Onglyza

(saxagliptin)

Onglyza (Saxagliptin) belongs to the group of Diabetes medications called DPP-4 inhibitors. It works by increasing the amount of incretin available in the body.

Available form

Dosage

Tablet

2.5MG, 5MG

Buy Onglyza Full drug details

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Onglyza information

Dosage

Side Effects

Available Form

Contraindications

Precautions

Warnings

The usual dose of Onglyza (Saxagliptin) is 5 mg taken by mouth once daily with or without food. Swallow the tablet whole with some fluid. Do not split the tablet.

Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.

It is important to take Onglyza (Saxagliptin) exactly as prescribed by your doctor. If you miss a dose, take it as soon as possible and continue with your regular schedule. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

Store Onglyza (Saxagliptin) at room temperature and keep it out of the reach of children.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.

The side effects listed below are not experienced by everyone who takes Onglyza (Saxagliptin). If you are concerned about side effects, discuss the risks and benefits of Onglyza (Saxagliptin) with your doctor.

The following side effects have been reported by at least 1% of people taking Onglyza (Saxagliptin). Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

headache
stomach upset

Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

blistering, red, or peeling skin
severe joint pain
signs of heart failure (e.g., sudden weight gain, difficulty breathing, leg swelling)
symptoms of a urinary tract infection, e.g.:

cloudy-looking or foul-smelling urine
frequent urge to urinate
pain or burning when urinating

symptoms of an upper respiratory tract infection, e.g.:

cough
Fever
headache
runny nose
sore throat

symptoms of low blood sugar, e.g.:

change in mood
change in vision
headache
hunger
rapid heartbeat
shaking
sweating

Stop taking the medication and seek immediate medical attention if any of the following occur:

signs of pancreatitis (e.g., abdominal pain on the upper left side, back pain, nausea, fever, chills, rapid heartbeat, swollen abdomen)
symptoms of a serious allergic reaction, e.g.:

difficulty breathing
Hives
skin rash
swelling of the face, lips, tongue, or throat

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking Onglyza (Saxagliptin).

There may be an interaction between Onglyza (Saxagliptin) and any of the following:

Abiraterone
acetylsalicylic acid
Amiodarone
angiotensin converting enzyme inhibitors (ACEIs; Captopril, Enalapril, Ramipril)
Apalutamide
atypical antipsychotics (e.g., Aripiprazole, Clozapine, Olanzapine, Quetiapine, Risperidone)
"azole" antifungals (e.g., fluconazole, itraconazole, ketoconazole, Voriconazole)
Bicalutamide
Carbamazepine
Carvedilol
Cobicistat
conivaptan
inhaled corticosteroids (e.g., budesonide, ciclesonide, fluticasone)
oral corticosteroids (e.g., Dexamethasone, Hydrocortisone, Prednisone)
Cyclosporine
Danazol
other diabetes medications (e.g., chlorpropamide, glyburide, insulin, metformin, Rosiglitazone)
Diltiazem
Dipyridamole
Disopyramide
diuretics (water pills; e.g., Furosemide, Hydrochlorothiazide, triamterene)
Dronedarone
Elagolix
Enzalutamide
estrogens (e.g., conjugated estrogen, Estradiol, ethinyl estradiol)
Flibanserin
Glucagon
grapefruit juice
Hepatitis C antivirals (e.g., daclatasvir, grazoprevir, ledipasvir, sofosbuvir)
HIV non-nucleoside reverse transcriptase inhibitors (NNRTIs; e.g., delavirdine, efavirenz, etravirine, nevirapine)
HIV protease inhibitors (e.g., atazanavir, indinavir, ritonavir, saquinavir)
Idelalisib
Lanreotide
luteinizing hormone-releasing hormone analogues (e.g., Buserelin, Goserelin, Leuprolide)
macrolide antibiotics (e.g., clarithromycin, erythromycin)
Mefloquine
mifepristone
Mitotane
monoamine oxidase inhibitors (M.O.S. e.g., Moclobemide, Phenelzine, Rasagiline, Selegiline, Tranylcypromine)
Niacin
Octreotide
Pasireotide
Pegvisomant
Phenobarbital
Phenytoin
primidone
progestins (e.g., Dienogest, Levonorgestrel, medroxyprogesterone, Norethindrone)
quinidine
quinine
quinolone antibiotics (e.g., ciprofloxacin, Norfloxacin, Ofloxacin)
rifampin
St. John's wort
selective serotonin reuptake inhibitors (SSRIs; e.g., Citalopram, Fluoxetine, Paroxetine, Sertraline)
Sirolimus
Stiripentol
sulfonamide antibiotics ("sulfas"; e.g., sulfisoxazole, sulfamethoxazole)
Tacrolimus
testosterone
tyrosine kinase inhibitors (e.g., Bosutinib, Dasatinib, imatinib, Nilotinib)
Verapamil
Vorinostat

If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

stop taking one of the medications,
change one of the medications to another,
change how you are taking one or both of the medications, or
leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with Onglyza (Saxagliptin). Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the Nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.

Before you begin taking a medication, be sure to inform your doctor of any medical conditions or Allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use Onglyza (Saxagliptin).

Blood sugar control: If your body experiences stress such as fever, trauma, infection, or surgery, you may lose control of blood glucose. Your doctor may decide to temporarily stop Onglyza (Saxagliptin) and advise you to take insulin. Talk to your doctor if you have fever, infection, or are about to undergo surgery.

Congestive Heart Failure (CHF): Heart failure has been reported in people taking Onglyza (Saxagliptin). If you have CHF or heart disease, discuss with your doctor how Onglyza (Saxagliptin) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Onglyza (Saxagliptin), and whether Onglyza (Saxagliptin) is appropriate for you.

Galactose intolerance/glucose malabsorption: Onglyza (Saxagliptin) is prepared with lactose. If you have lactose or galactose intolerance speak with your doctor about whether Onglyza (Saxagliptin) is appropriate for you.

Hypoglycemia: Onglyza (Saxagliptin) may increase the risk of hypoglycemia (low blood sugar) when taking Onglyza (Saxagliptin) with a sulfonylurea or insulin. If you are taking Onglyza (Saxagliptin) with another medication to reduce blood sugar, your doctor may recommend a lower dose of the other medication.

If you experience low blood sugar (e.g., headache, drowsiness, weakness, dizziness, confusion, irritability, hunger, fast heartbeat, sweating, and feeling jittery) contact your doctor.

Immune system: If you have a weakened immune system (e.g., you have had an organ transplant or have HIV), discuss with your doctor how Onglyza (Saxagliptin) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Onglyza (Saxagliptin), and whether any special monitoring is needed.

Kidney function: Kidney Disease or reduced kidney function may cause Onglyza (Saxagliptin) to build up in the body, causing side effects. If you have reduced kidney function or kidney disease, discuss with your doctor how Onglyza (Saxagliptin) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Onglyza (Saxagliptin), and whether any special monitoring is needed.

Onglyza (Saxagliptin) may also cause reduced kidney function. Your doctor may recommend regular testing to check your kidney function while you are taking Onglyza (Saxagliptin). Onglyza (Saxagliptin) is not recommended for people with end-stage renal disease and those on dialysis.

Liver function: Liver disease or reduced liver function may cause Onglyza (Saxagliptin) to build up in the body, causing side effects. If you have liver problems, discuss with your doctor how Onglyza (Saxagliptin) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Onglyza (Saxagliptin), and whether any special monitoring is needed. Your doctor may want to test your liver function regularly with blood tests while you are taking Onglyza (Saxagliptin).

Onglyza (Saxagliptin) is not recommended for people with moderately or severely reduced liver function.

Pancreatitis: Onglyza (Saxagliptin) can cause the pancreas to become inflamed. If you have a history of pancreatitis, discuss with your doctor how Onglyza (Saxagliptin) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Onglyza (Saxagliptin), and whether any special monitoring is needed.

Report signs of pancreatitis such as abdominal pain on the upper left side, back pain, nausea, fever, chills, rapid heartbeat, or swollen abdomen to your doctor immediately.

Type 1 diabetes and diabetic ketoacidosis: Onglyza (Saxagliptin) should not be used to treat type 1 diabetes, diabetic pre-coma or coma, or diabetic ketoacidosis (increased ketones in the blood or urine).

Pregnancy: Onglyza (Saxagliptin) is not recommended for use during pregnancy. If you become pregnant while taking Onglyza (Saxagliptin), contact your doctor immediately.

Breast-feeding: It is not known if Onglyza (Saxagliptin) passes into breast milk. If you are a breast-feeding mother and are taking Onglyza (Saxagliptin), it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.

Children: The safety and effectiveness of using Onglyza (Saxagliptin) have not been established for children.

Seniors: People over the age of 65 may be more at risk of developing side effects from Onglyza (Saxagliptin).

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