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Votrient

Votrient

(pazopanib)

Votrient (Pazopanib) belongs to the group of cancer-fighting medications known as antineoplastics and more specifically to a class of medications called tyrosine kinase inhibitors. These medications are antitumour medications that slow the growth of blood vessels that feed nutrients to cancer cells.

Available form

Dosage

Tablet

200MG

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Votrient information

Dosage

Side Effects

Available Form

Contraindications

Precautions

Warnings

The recommended dose of Votrient (Pazopanib) is 800 mg taken by mouth, once a day. Votrient (Pazopanib) should be taken on an empty stomach, at least 1 hour before or 2 hours after a meal, for the best effect.

Votrient (Pazopanib) must not be crushed or broken. Swallow the tablets whole, with a glass of water.

Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.

It is important to take Votrient (Pazopanib) exactly as prescribed by your doctor. If you miss a dose, take it as soon as possible and continue with your regular schedule. If it is less than 12 hours until your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

Store Votrient (Pazopanib) at room temperature, protect it from light and moisture, and keep it out of the reach of children.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.

The side effects listed below are not experienced by everyone who takes Votrient (Pazopanib). If you are concerned about side effects, discuss the risks and benefits of Votrient (Pazopanib) with your doctor.

The following side effects have been reported by at least 1% of people taking Votrient (Pazopanib). Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

changes in the way things taste
changes to skin and/or hair colour
cough
Diarrhea
dizziness
dry skin
gas
hair loss or thinning
headache
hoarseness
increased sweating
indigestion
lack of energy
loss of appetite
loss of strength
mouth sores
muscle, joint, or bone pain
muscle spasms
nausea
nail changes
prickling, crawling sensation on the skin
skin rash
stomach pain or discomfort
tiredness
tumour pain
trouble sleeping
vomiting
weakness
weight loss

Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

chest pain
decreased heart rate
diarrhea with Fever or more than 3 episodes per day
increased blood pressure
irregular heartbeat
prickling, tingling, or numbness in the arms or legs
signs of bleeding (e.g., bloody nose, blood in urine, coughing blood, bleeding gums, cuts that don't stop bleeding)
signs of decreased heart function (e.g., cough, wheeze, fatigue, difficulty breathing when resting or lying down, swollen ankles and feet)
signs of decreased Thyroid function (e.g., Constipation, dry skin, tiredness, weight gain, sensitive to the cold)
signs of dehydration (e.g., decreased urine, dry skin, dry and sticky mouth, sleepiness, dizziness, headache, thirst, confusion)
signs of infection (fever, severe chills, sore throat, mouth ulcers)
signs of abnormal liver function (e.g., skin or whites of the eyes turning yellow; feeling tired; dark or brown coloured urine; nausea, vomiting or not wanting to eat)
symptoms of a urinary tract infection (e.g. pain when urinating, urinating more often than usual, low back or flank pain)
swelling of the hands, ankles, or feet
symptoms of lung inflammation (e.g., cough, shortness of breath)
tingling, numbness, pain, redness, or swelling on palms of hands or soles of feet
symptoms of too much potassium in the body (e.g., muscle fatigue, weakness, difficulty moving, abnormal heart rhythms, nausea)
vision changes

Stop taking the medication and seek immediate medical attention if any of the following occur:

collapsed lung (e.g., shortness of breath, sudden chest pain)
seizures
signs of bleeding in the lung or in the stomach (e.g., bloody, black, or tarry stools; spitting up of blood; vomiting blood or material that looks like coffee grounds)
signs of a blood clot (e.g., sudden chest pain, shortness of breath, sudden leg pain, leg swelling, or leg redness)
signs of Heart Attack (e.g., sudden chest pain or pain radiating to back, down arm, jaw; sensation of tightness or pressure of the chest; nausea; vomiting; sweating; anxiety)
signs of an irregular heartbeat (e.g., dizziness, palpitations [pounding or racing heartbeat], fainting, or loss of consciousness)
signs of pancreatitis (e.g., abdominal pain on the upper left side, back pain, nausea, fever, chills, rapid heartbeat, swollen abdomen)
signs of a rare neurological disorder called reversible posterior leukoencephalopathy syndrome (RPLS; e.g., confusion, dizziness, headache, high blood pressure, seizures, vision problems, or blindness)
signs of Stroke (e.g., sudden or severe headache; sudden loss of coordination; vision changes; sudden slurring of speech; or unexplained weakness, numbness, or pain in arm or leg)
signs of swelling in the brain (e.g., clumsiness; gradually worsening weakness; visual, speech, or personality changes; seizures)
sudden, severe pain in the back, neck, or abdomen
symptoms of a fistula (e.g., diarrhea, rectal bleeding, weight loss)

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking Votrient (Pazopanib).

Before you begin using a medication, be sure to inform your doctor of any medical conditions or Allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use Votrient (Pazopanib).

Abnormal heart rhythms: Votrient (Pazopanib) may cause a heart rhythm problem called QT prolongation. If you have a history of QT prolongation, slow or irregular heartbeat, irregular heart rhythm, heart failure, heart attack, heart disease, taking other medications known to cause QT prolongation, or a family history of sudden cardiac death at less than 50 years of age, discuss with your doctor how Votrient (Pazopanib) may affect your medical condition and how your medical condition may affect the dosing and effectiveness of Votrient (Pazopanib). Your doctor will perform tests at regular intervals to monitor for any changes in your heart rhythm.

Bleeding problems: Votrient (Pazopanib) may increase your risk of bleeding. If you have a history of coughing up blood, brain bleeds, or bleeding from the stomach, discuss with your doctor how Votrient (Pazopanib) may affect your medical condition. If you notice signs of serious bleeding, such as vomiting blood or a coffee grounds-like substance or bleeding from the rectum, get immediate medical attention.

Blood Clots: Votrient (Pazopanib) may increase the chance of blood clot formation, causing reduction of blood flow to organs or the extremities.

If you have a history of clotting you may be at increased risk of experiencing blood clot-related problems such as heart attack, stroke, or clots in the deep veins of your leg. Discuss with your doctor how Votrient (Pazopanib) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Votrient (Pazopanib), and whether any special monitoring is needed.

If you experience symptoms such as sharp pain and swelling in the leg, difficulty breathing, chest pain, blurred vision, or difficulty speaking, contact your doctor immediately.

Congestive Heart Failure (CHF): Votrient (Pazopanib) may make the heart less effective at pumping blood through the body, causing congestive heart failure and reduced heart function. If you have a history of heart disease or you are at risk of developing heart disease, discuss with your doctor how Votrient (Pazopanib) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Votrient (Pazopanib), and whether any special monitoring is needed.

Gastrointestinal (stomach and bowel) problems: Rarely, Votrient (Pazopanib) can cause perforation (holes) in the stomach or intestines. If you experience severe abdominal pain, fever, vomiting, or black and tarry stools, contact your doctor immediately.

Grapefruit juice: Grapefruit juice affects how Votrient (Pazopanib) is removed from the body and may cause too much of the medication to build up in the body and cause possibly harmful side effects. People should not drink grapefruit juice or eat grapefruit at anytime while taking Votrient (Pazopanib) for treatment.

High blood pressure: Votrient (Pazopanib) can cause increased blood pressure. People with uncontrolled high blood pressure should be closely monitored closely by their doctor.

If you experience symptoms of a severe increase in blood pressure, such as severe chest pain, headache with confusion, nausea, vomiting, or shortness of breath, contact your doctor immediately.

Infection: Votrient (Pazopanib), like other medications used to treat cancer, can reduce the number of cells that fight infection in the body (white blood cells). If possible, avoid contact with people with contagious infections. Tell your doctor immediately if you notice signs of an infection, such as fever or chills, severe diarrhea, shortness of breath, prolonged dizziness, headache, stiff neck, weight loss, or listlessness. Your doctor will do blood tests regularly to monitor the number of specific types of blood cells in your blood.

Kidney function: Votrient (Pazopanib) has been linked with decreased kidney function. If you experience symptoms of kidney problems, such as fluid retention and puffiness in the lower legs and feet, talk to your doctor.

If you have a history of kidney problems, discuss with your doctor how Votrient (Pazopanib) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Votrient (Pazopanib), and whether any special monitoring is needed.

Reversible Posterior Leukoencephalopathy Syndrome (RPLS): This is a rare condition of the brain where the covering that protects the nerves is destroyed, affecting how the nerves in the brain transmit messages. Signs and symptoms of leukoencephalopathy include unusual clumsiness, gradually worsening weakness, visual, speech or personality changes, or possibly seizures. If you experience any of these, contact your doctor immediately.

Liver function: Liver disease or reduced liver function may cause Votrient (Pazopanib) to build up in the body, causing side effects. If you have liver problems, discuss with your doctor how Votrient (Pazopanib) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Votrient (Pazopanib), and whether any special monitoring is needed.

Votrient (Pazopanib) has been reported to cause liver failure, which has in cases, caused death. Votrient (Pazopanib) may also cause a decrease in liver function. If you experience symptoms of liver problems such as fatigue, feeling unwell, loss of appetite, nausea, yellowing of the skin or whites of the eyes, dark urine, pale stools, abdominal pain or swelling, and itchy skin, contact your doctor immediately.

Your doctor may want to test your liver function regularly with blood tests while you are taking Votrient (Pazopanib). This often allows reduced liver function to be identified before it becomes too severe.

Lung inflammation: Lung inflammation (interstitial lung disease), causing difficulty breathing has occurred rarely in some people taking Votrient (Pazopanib). This complication can be serious and sometimes fatal. If you experience new or worsening shortness of breath or cough (with or without fever) at any time while you are taking Votrient (Pazopanib), contact your doctor immediately.

Reproduction: Votrient (Pazopanib) may decrease fertility for both men and women. Discuss with your doctor any concerns you have about having children in the future. Women of childbearing age who are taking Votrient (Pazopanib) should use an effective method of birth control (e.g., birth control pill, condoms) during treatment and for 8 weeks after treatment. Votrient (Pazopanib) has also been linked to birth defects in babies born to mothers whose male partner used the medication during the pregnancy. Men whose partners are or may become pregnant should use a barrier form of birth control, such as condoms, while taking Votrient (Pazopanib) and for at least 2 weeks after taking the last dose.

Surgery: Votrient (Pazopanib) may reduce the speed of wound healing. If you have a surgery scheduled, let the doctors and nurses involved with your care know that you are taking Votrient (Pazopanib). Your doctor may want you to stop taking Votrient (Pazopanib) temporarily until you have recovered from the surgery.

Thyroid function: Votrient (Pazopanib) may reduce the function of the thyroid gland. If you have thyroid disease, discuss with your doctor how Votrient (Pazopanib) may affect your medical condition. Your doctor may want to test your thyroid function regularly with blood tests while you are taking Votrient (Pazopanib).

Pregnancy: Votrient (Pazopanib) may cause harm to an unborn fetus if taken by the mother while she is pregnant. It should not be used during pregnancy. If you become pregnant while taking Votrient (Pazopanib), contact your doctor immediately.

Breast-feeding: It is not known if Votrient (Pazopanib) passes into breast milk. If you are a breast-feeding mother and are taking Votrient (Pazopanib), it may affect your baby. Talk to your doctor about breast-feeding, as it is recommended that breast-feeding be stopped while using Votrient (Pazopanib).

Children: The safety and effectiveness of using Votrient (Pazopanib) have not been established for children less than 18 years of age and is not recommended for this age group. Do not give Votrient (Pazopanib) to children less than 2 years of age as it severely affects body weight gain, organ growth, and maturation, and may cause serious problems with a child's growth.

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All material © 1996-2024 MediResource Inc. Terms and conditions of use. The contents herein are for informational purposes only. Always seek the advice of your physician or other qualified health providers with any questions you may have regarding a medical condition.

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