Home > Drug >

Diphenhydramine

Diphenhydramine

Diphenhydramine belongs to a group of medications known as antihistamines. Antihistamines are used to treat symptoms caused by Allergies, including itchy and watery eyes, sneezing, runny nose, and skin rash and irritations.

Available form

Tablet, Tablet, Capsule, Tablet, Injectable, Elixir, Syrup, Strip

Dosage

6.25mg/5ml, 10mg/ml, 12.5mg, 12.5mg/5ml, 19mg, 25mg, 50mg/ml, 50mg

Manufacturers

Jamp Pharma Corporation, Johnson & Johnson, Juno, Laboratoire Riva, Laboratoires Confab, Novartis Pharmaceuticals, Omega Laboratories, Pendopharm Division Of Pharmascience Inc, Pharmascience, Sandoz

Branded drugs

Benadryl

Buy Diphenhydramine Full drug details

What is Pocketpills?

As Canada's leading online pharmacy, we make sure you always have your meds on time. Use our app and website to fill prescriptions, order refills, and consult with our pharmacists. Take control of your health from home or on the go!

Easy refills, renewals, and reminders
Quick answers to your questions
Free delivery with SMS updates

Join us

We'd love to tell you more

We won't bore you with the details, but Health Canada requires you to sign in.

By proceeding you agree to our Terms of Use & Privacy Policy

Diphenhydramine information

Dosage

Side Effects

Available Form

Contraindications

Precautions

Warnings

Adults and children 12 years of age and older: The usual dose is 25 mg to 50 mg taken by mouth 3 or 4 times a day. No more than 200 mg should be taken in a 24-hour period. As there are various strengths and forms of diphenhydramine, talk to your doctor or pharmacist before taking Diphenhydramine. Take diphenhydramine exactly as directed by your doctor or pharmacist.

Children 6 to 11 years of age: The usual dose is 12.5 mg to 25 mg every 4 to 6 hours. No more than 100 mg should be taken in a 24-hour period.

Children 2 to 5 years of age: The usual dose is 6.25 mg every 4 to 6 hours. No more than 25 mg should be taken in a 24-hour period.

Children under 2 years of age: The usual dose is 3.125 mg every 4 to 6 hours. No more than 12.5 mg should be taken in a 24-hour period.

Do not give diphenhydramine capsules or caplets to children younger than 12 years of age unless directed to do so by your child's doctor. As there are various strengths and forms (e.g., children's liquid, elixir) of diphenhydramine, talk to your doctor or pharmacist before giving Diphenhydramine to a child.

Use an oral syringe to measure each dose of the liquid, as it gives a more accurate measurement than household teaspoons.

Cream: For adults and children 2 years and over, apply a thin layer of cream 3 or 4 times a day to the affected area. If the skin condition worsens or persists for longer than 7 days, do not continue this medication without consulting your doctor or pharmacist. Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones above, do not change the way that you are using the medication without consulting your doctor.

It is important to use Diphenhydramine exactly as recommended by your doctor or pharmacist.

Store Diphenhydramine at room temperature and keep it out of the reach of children.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use Diphenhydramine.

Asthma or breathing problems: Diphenhydramine can cause the secretions produced in the lungs to become thick and difficult to clear out of the lungs. If you have breathing problems such as asthma or COPD (Chronic Obstructive Pulmonary Disease) (COPD), discuss with your doctor discuss with your doctor how Diphenhydramine may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Diphenhydramine, and whether any special monitoring is needed.

Drowsiness/reduced alertness: Diphenhydramine can cause drowsiness. Avoid driving or operating machinery until you have determined that Diphenhydramine does not affect your ability to perform these tasks safely.

Glaucoma: Diphenhydramine may cause the symptoms of glaucoma (increased pressure in the eye) to become worse. If you have glaucoma, discuss with your doctor how Diphenhydramine may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Diphenhydramine, and whether any special monitoring is needed. Report any changes in vision to your doctor as soon as possible while you are taking this medication.

Skin conditions: The topical cream should not be used on chickenpox, measles, or extensive areas of the skin. Avoid applying the cream to raw or open areas of skin. If the condition worsens or lasts for longer than 7 days, contact your doctor. Other medications containing diphenhydramine (e.g., tablets, capsules, liquids) should not be used while using the cream.

Stomach ulcers: Diphenhydramine may make the symptoms of stomach ulcers worse. If you have stomach problems, discuss with your doctor how Diphenhydramine may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Diphenhydramine, and whether any special monitoring is needed.

Urinary tract problems: Diphenhydramine can make passing urine more difficult, increasing the symptoms of an enlarged prostate gland or other urinary tract problems. If you have prostate problems or difficulty passing urine, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Diphenhydramine, and whether any special monitoring is needed.

Pregnancy: Diphenhydramine should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking Diphenhydramine, contact your doctor immediately.

Breast-feeding: The safety of using Diphenhydramine while breast-feeding has not been established. If you are a breast-feeding mother and are taking Diphenhydramine, it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.

Children: Children are at an increased risk of overdose and side effects from Diphenhydramine. Antihistamines such as diphenhydramine can cause excitation in young children.

Seniors: If you are a senior, Diphenhydramine may be more likely to cause dizziness, drowsiness, and Low Blood Pressure. Talk to your doctor or pharmacist before taking Diphenhydramine.

Continue with Pocketpills

All material © 1996-2025 MediResource Inc. Terms and conditions of use. The contents herein are for informational purposes only. Always seek the advice of your physician or other qualified health providers with any questions you may have regarding a medical condition.

Helpful links

See these other medications
that relate to

Clemastine

Dimenhydrinate

Doxylamine + Vitamin-b6

Gravol

FAQs

Do I need a valid prescription (Rx) to order prescription medication?

Yes, you need a valid prescription, or Rx for short, from a Canadian prescriber to purchase medication that requires a prescription. If you need a new prescription, please contact us and we can help connect you with a doctor or we will reach out to your doctor for a renewal.

How can I refill my medication?

We will gladly coordinate with your doctor and insurance company to make sure you never run out of the medication you need. Additionally, we will remind you when it's time to schedule a delivery for your refill. You can also opt into automatic refills online, in the app, or by calling us at 1-855-950-7225.

Is Pocketpills free? How much does it cost?

Yes, Pocketpills services are free! You only pay your portion of your copay, and there are no hidden delivery or service fees. We'll transfer your prescriptions from your old pharmacy, find savings, and hand-deliver your medications at no extra cost.

What insurance plans do you accept?

We accept all insurance plans and direct bill ODB, OHIP+, and PharmaCare.

How much is shipping cost For Diphenhydramine in Canada?

Shipping cost for Diphenhydramine to you in Canada is zero. Pocketpills offers FREE shipping anywhere in Canada to help you get access to treatment.

How to get Diphenhydramine delivered to my home?

You could get Diphenhydramine delivered at your doorstep from us in Canada if you ordered prescription medications with a valid prescription. If you are not sure if we deliver to your area, contact us.