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Vincristine

Vincristine

(vincristine)

Vincristine belongs to the group of cancer-fighting medications known as antineoplastics. It causes the death of cancer cells by interfering with the genetic material DNA, which is necessary for their growth and reproduction.

Available form

Dosage

Injectable

1MG/ML

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Vincristine information

Dosage

Side Effects

Available Form

Contraindications

Precautions

Warnings

The recommended dose and dosing schedule of vincristine varies according to the specific type of cancer being treated, the response to therapy, and the other drugs or treatments being used. The dose administered is also based on body size.

Vincristine is injected into a vein through a specially prepared site on your skin that has been prepared for this purpose. Very careful handling of Vincristine is required. It is always given under the supervision of a doctor in a hospital or similar setting with access to sterile equipment for preparation.

As well as interfering with the genetic material DNA of cancer cells, vincristine can interfere with some of your normal cells. This can cause a number of side effects such as hair loss. Vincristine sometimes causes mild nausea and vomiting, but it is important to keep using Vincristine even if you feel ill.

Your doctor, nurse, or pharmacist can advise you on how to reduce the effects of nausea and vomiting. Your doctor may want you to drink extra fluids while using Vincristine to prevent kidney problems. Keep track of any side effects and report them to your doctor as suggested in the section "What side effects are possible with Vincristine?"

Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.

It is important to take Vincristine exactly as prescribed by your doctor. If you miss an appointment to receive vincristine, contact your doctor as soon as possible to reschedule your appointment.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.

The side effects listed below are not experienced by everyone who takes Vincristine. If you are concerned about side effects, discuss the risks and benefits of Vincristine with your doctor.

The following side effects have been reported by at least 1% of people taking Vincristine. Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

abdominal cramps
back pain
bloating
Constipation
Diarrhea
headache
jaw pain
joint pain
muscle aches
nausea
skin rash
sleeping problems
temporary loss of hair
vomiting

Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

prolonged constipation
decreased coordination
decrease or increase in urination
difficulty moving
dizziness or lightheadedness when getting up from a sitting or lying position
drooping eyelids
blood pressure changes (increased or decreased)
lower back or side pain
numbness or tingling in fingers and toes
pain in fingers and toes
painful or difficult urination
signs of infection (symptoms may include Fever or chills, severe diarrhea, shortness of breath, prolonged dizziness, headache, stiff neck, weight loss, or listlessness)
sores in mouth and on lips
unusual bleeding or bruising
vision changes
weakness

Get medical help immediately if any of the following occur:

seizures

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking this medication.

There may be an interaction between vincristine and any of the following:

Amiodarone
Apalutamide
Aprepitant
azole antifungal medications (e.g., itraconazole, ketoconazole, Voriconazole)
BCG vaccine
Baricitinib
Bosentan
calcium channel blockers (e.g., Amlodipine, Diltiazem, Verapamil)
Carvedilol
conivaptan
Cyclosporine
Deferasirox
Denosumab
Dronedarone
echinacea
Elagolix
Eliglustat
Enzalutamide
Fingolimod
Flibanserin
grapefruit juice
Hepatitis C antivirals (e.g., daclatasvir, dasabuvir, ombitasvir, paritaprevir)
HIV non-nucleoside reverse transcriptase inhibitors (NNRTIs; e.g., efavirenz, etravirine, nevirapine)
HIV protease inhibitors (e.g., atazanavir, indinavir, ritonavir, saquinavir)
Leflunomide
lumacaftor
macrolide antibiotics (e.g., clarithromycin, erythromycin)
mifepristone
Modafinil
Natalizumab
Ocrelizumab

Pimecrolimus
Propafenone
protein kinase inhibitors (e.g., Crizotinib, Dabrafenib, imatinib, Lapatinib, Nilotinib, Sunitinib)
quinidine
quinine
rifabutin
rifampin
St. John's wort
Sarilumab
seizure medications (e.g., Carbamazepine, Phenobarbital, Phenytoin, primidone)
Stiripentol
Tacrolimus
Tocilizumab
Tofacitinib
vaccines

If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

stop taking one of the medications,
change one of the medications to another,
change how you are taking one or both of the medications, or
leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with this medication. Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the Nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.

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All material © 1996-2024 MediResource Inc. Terms and conditions of use. The contents herein are for informational purposes only. Always seek the advice of your physician or other qualified health providers with any questions you may have regarding a medical condition.

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