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Tukysa

Tukysa

(tucatinib)

Tukysa (Tucatinib) belongs to the class of medications called antineoplastics (anticancer medications). Specifically, it is a protein kinase inhibitor.

Available form

Dosage

Tablet

50MG

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Tukysa information

Dosage

Side Effects

Available Form

Contraindications

Precautions

Warnings

The recommended dose of Tukysa (Tucatinib) is 300 mg (two 150 mg tablets) taken by mouth two times a day, along with Trastuzumab and Capecitabine. Tukysa (Tucatinib) tablets should be swallowed whole with some water. Do not crush, chew, or split these tablets. They may be taken with or without food, and at the same time as capecitabine. Try to take the two doses 12 hours apart, at about the same time every day.

Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.

It is important to take Tukysa (Tucatinib) exactly as prescribed by your doctor.

If you vomit after taking a dose of Tukysa (Tucatinib), do not take another dose. Take your next dose at your usual dose time. If you miss a dose, take it as soon as possible and continue with your regular schedule. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice .

Store Tukysa (Tucatinib) in its original container at room temperature. Protect it from light and moisture, and keep it out of the reach of children. If you have any medication remaining in the original container 3 months after opening the bottle, safely discard the medication.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.

The side effects listed below are not experienced by everyone who takes Tukysa (Tucatinib). If you are concerned about side effects, discuss the risks and benefits of Tukysa (Tucatinib) with your doctor.

The following side effects have been reported by at least 1% of people taking Tukysa (Tucatinib). Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

abdominal pain
decreased appetite
flu-like symptoms (e.g., fatigue, Fever, sore throat, headache, sudden lack of energy)
hair loss
joint pain
low energy level
mouth sores
muscle weakness
nausea
night sweats
nosebleeds
open wounds or sores
redness or swelling in the mouth
trouble swallowing
vomiting
weight loss

Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

accidental urination
bleeding from the rectum
chest discomfort or pain
Diarrhea
fast, pounding heartbeat
fever
pain, tingling, or numbness in the hands or feet
painful urination
rash
signs of Anemia (low red blood cells; e.g., dizziness, pale skin, unusual tiredness or weakness, shortness of breath)
signs of dehydration (e.g., decreased urine, dry skin, dry and sticky mouth, sleepiness, dizziness, headache, thirst, confusion)
signs of Depression (e.g., poor concentration, changes in weight, changes in sleep, decreased interest in activities, thoughts of suicide)
signs of hand-foot syndrome (e.g., painful swelling, blistering, redness of the palms of the hands or soles of the feet)
signs of heart failure (e.g., fast, irregular heartbeat or pulse, chest pain, sudden weight gain, difficulty breathing, leg swelling)
signs of liver problems (e.g., nausea, vomiting, diarrhea, loss of appetite, weight loss, yellowing of the skin or whites of the eyes, dark urine, pale stools)
symptoms of Low Blood Pressure (e.g., dizziness or lightheadedness when rising from a sitting or lying position)
unexplained vaginal bleeding

Stop taking the medication and seek immediate medical attention if any of the following occur:

seizures
symptoms of a severe infection (blood infection causing dangerously low blood pressure; fever, dizziness, chills, rapid breathing, fast heartbeat)

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking Tukysa (Tucatinib).

Before you begin using a medication, be sure to inform your doctor of any medical conditions or Allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use Tukysa (Tucatinib).

Birth control: The effects on the developing baby if either parent is taking Tukysa (Tucatinib) during pregnancy have not been determined. It is likely that exposure to Tukysa (Tucatinib) could cause harm to the baby. Women who could become pregnant and are taking Tukysa (Tucatinib) should use an effective method of birth control such as condoms during treatment and for 1 week after the last dose of Tukysa (Tucatinib).

Men taking Tukysa (Tucatinib) who have partners who could become pregnant should use effective birth control during treatment and for 1 week after the last dose.

Diarrhea: Tukysa (Tucatinib) can cause diarrhea that can lead to dehydration. Dehydration can cause many symptoms, including decreased urine production, dry and sticky mouth, sleepiness, dizziness, headache, thirst, and confusion. In some cases, dehydration can become a medical emergency. If you have diarrhea or any of these symptoms while taking Tukysa (Tucatinib), let your doctor know.

Hand-foot syndrome: Hand-foot syndrome (Palmar-plantar erythrodysesthesia syndrome) is a side effect of some cancer treatments, including Tukysa (Tucatinib). This side effect causes painful redness, blisters, and swelling on the palms of the hands and soles of the feet. If you experience these symptoms, tell your doctor as soon as possible.

Kidney function: Tukysa (Tucatinib) should not be used by people with severely decreased kidney function.

Liver function: Decreased liver function or liver disease may cause Tukysa (Tucatinib) to build up in the body, causing side effects. If you have liver problems, discuss with your doctor how Tukysa (Tucatinib) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Tukysa (Tucatinib), and whether any special monitoring is needed.

Tukysa (Tucatinib) can cause liver damage and decreased liver function. If you experience symptoms of liver problems such as fatigue, feeling unwell, loss of appetite, nausea, yellowing of the skin or whites of the eyes, dark urine, pale stools, abdominal pain or swelling, and itchy skin, contact your doctor immediately.

Pregnancy: There is no information about the safety and effectiveness of using Tukysa (Tucatinib) while pregnant. Tukysa (Tucatinib) should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking Tukysa (Tucatinib), contact your doctor immediately.

Breast-feeding: It is not known if Tukysa (Tucatinib) passes into breast milk. If you are breast-feeding and are taking Tukysa (Tucatinib), it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.

Children: The safety and effectiveness of using Tukysa (Tucatinib) have not been established for children.

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