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Juxtapid

Juxtapid

(lomitapide)

Juxtapid (Lomitapide) belongs to the class of medications called triglyceride transfer protein inhibitors. It is used, in addition to a low-fat diet and other lipid lowering medications, to reduce the amount of LDL cholesterol ("bad" cholesterol) in the blood, for adults who have a genetic condition called homozygous familial hypercholesterolemia (HoFH) that causes the body to produce too much LDL cholesterol.

Available form

Dosage

Capsule

5MG

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Juxtapid information

Dosage

Side Effects

Available Form

Contraindications

Precautions

Warnings

The recommended starting dose of Juxtapid (Lomitapide) for adults is 5 mg taken once daily. After 2 weeks, the dose can be increased to 10 mg taken once daily. If necessary, the dose can be increased at 4 week intervals as it is tolerated. The maximum recommended dose is 60 mg daily.

Juxtapid (Lomitapide) capsules should be swallowed whole with a glass of water. Do not open, crush, dissolve, or chew the capsules.

Food may cause side effects such as nausea and Diarrhea, therefore, Juxtapid (Lomitapide) should be taken without food, at least 2 hours after the evening meal.

Your doctor may also prescribe Vitamin E and essential fatty acids for you to take while you are taking Juxtapid (Lomitapide). These supplements should not be taken within 2 hours of Juxtapid (Lomitapide). It is recommended that these dietary supplements be taken in the morning.

Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.

It is important to take Juxtapid (Lomitapide) exactly as prescribed by your doctor.

If you miss a dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

Store Juxtapid (Lomitapide) at room temperature, protect it from light and moisture, and keep it out of the reach of children.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

There may be an interaction between Juxtapid (Lomitapide) and any of the following:

Acetaminophen
alcohol
Amiodarone
Aprepitant
Aripiprazole
"azole" antifungals (e.g., fluconazole, itraconazole, ketoconazole, voriconazole)
barbiturates (e.g., pentobarbital, Phenobarbital)
benzodiazepines (e.g., Chlordiazepoxide, Clonazepam, Diazepam, Lorazepam)
Bicalutamide
birth control pills
Bosentan
calcium channel blockers (e.g., amlodipine, diltiazem, nifedipine, verapamil)
Carbamazepine
Cholestyramine
Cimetidine
ciprofloxacin
Cobicistat
Colchicine
Colesevelam
Colestipol
conivaptan
Cyclosporine
dabigatran
Danazol
dabigatran
Deferasirox
Desipramine
Dexamethasone
Digoxin
dofetilide
dronedarone
Enzalutamide
estrogens (e.g., conjugated estrogen, Estradiol, ethinyl estradiol)
ezetimbe
fenfibrate
Everolimus
"gliptin" Diabetes medications (e.g., Linagliptin, Saxagliptin, Sitagliptin)
grapefruit juice
HIV non-nucleoside reverse transcriptase inhibitors (NNRTIs; e.g., delavirdine, efavirenz, etravirine, nevirapine)
HIV protease inhibitors (e.g., atazanavir, indinavir, ritonavir, saquinavir)
Hydrocodone
isoniazid
Ivacaftor
Lurasidone
macrolide antibiotics (e.g., clarithromycin, erythromycin)
maraviroc
Methotrexate
mifepristone
Mitotane
Modafinil
nefazodone
Phenytoin
Pimozide
primidone
quinidine
Ranitidine
rifabutin
rifampin
Sarilumab
St. John's wort
selective serotonin reuptake inhibitors (SSRIs; e.g., Citalopram, Fluoxetine, Paroxetine, Sertraline)
Seville oranges
siltuximab
Sirolimus
"statin" anti-cholesterol medications (e.g., Atorvastatin, Lovastatin, simvastatin)
Stiripentol
Tamoxifen
Tetracycline
Ticagrelor
Tocilizumab
Tolvaptan
tretinoin
tricyclic antidepressants (e.g., Amitriptyline, Clomipramine, desipramine, Trimipramine)
tyrosine kinase inhibitors (e.g., Dasatinib, imatinib, Pazopanib)
Warfarin

If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

stop taking one of the medications,
change one of the medications to another,
change how you are taking one or both of the medications, or
leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with Juxtapid (Lomitapide). Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the Nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.

Before you begin using a medication, be sure to inform your doctor of any medical conditions or Allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use Juxtapid (Lomitapide).

Alcohol use: Consuming alcohol when taking Juxtapid (Lomitapide) increases the risk of liver damage. It is advisable to limit the amount of alcohol to no more than one drink daily while you are taking Juxtapid (Lomitapide).

Birth control: Women who may become pregnant while taking Juxtapid (Lomitapide) should use effective birth control. Diarrhea or vomiting caused by Juxtapid (Lomitapide) may cause oral contraceptives (birth control pills) to become ineffective. Use a second method of birth control until these symptoms subside. If you are using birth control pills, you should separate your dose of Juxtapid (Lomitapide) by 12 hours.

Kidney function: Kidney Disease or reduced kidney function may cause Juxtapid (Lomitapide) to build up in the body, causing side effects. If you have reduced kidney function or kidney disease, discuss with your doctor how Juxtapid (Lomitapide) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Juxtapid (Lomitapide), and whether any special monitoring is needed.

Liver function: Juxtapid (Lomitapide) may reduce liver function and cause a fatty liver. Liver disease or reduced liver function may cause Juxtapid (Lomitapide) to build up in the body, causing side effects. If you have liver problems, discuss with your doctor how Juxtapid (Lomitapide) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Juxtapid (Lomitapide), and whether any special monitoring is needed. Your doctor may want to test your liver function regularly with blood tests while you are taking Juxtapid (Lomitapide).

If you experience symptoms of liver problems such as fatigue, feeling unwell, loss of appetite, nausea, yellowing of the skin or whites of the eyes, dark urine, pale stools, abdominal pain or swelling, and itchy skin, contact your doctor immediately.

Pregnancy: Juxtapid (Lomitapide) should not be used by a woman who is pregnant as it may cause harm to the developing baby. If you become pregnant while taking Juxtapid (Lomitapide), contact your doctor immediately.

Breast-feeding: It is not known if Juxtapid (Lomitapide) passes into breast milk. If you are a breast-feeding mother and are taking Juxtapid (Lomitapide), it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.

Children: The safety and effectiveness of using Juxtapid (Lomitapide) have not been established for children.

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