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Cerdelga

Cerdelga

(eliglustat)

Cerdelga (Eliglustat) belongs to the class of medications called alimentary tract and metabolism products. It is used to treat a genetic disorder called Type 1 Gaucher Disease.

Available form

Dosage

Capsule

84MG

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Cerdelga information

Dosage

Side Effects

Available Form

Contraindications

Precautions

Warnings

The recommended dose depends on liver function, specifically how well the CYP2D6 enzyme works to metabolize (break down) medications. This will be determined by a blood test that will be done before you start treatment.

The recommended dose for intermediate and extensive CYP2D6 metabolizers is 84 mg taken by mouth 2 times a day.

The recommended dose of poor CYP2D6 metabolizers is 1 capsule taken by mouth, once daily.

Cerdelga (Eliglustat) works best if it is taken at the same time each day.

Swallow the capsules whole with water. Do not crush, dissolve or chew the capsules. Cerdelga (Eliglustat) may be taken with food or on an empty stomach. Do not drink grapefruit juice while taking Cerdelga (Eliglustat) as it can cause increased blood levels of Cerdelga (Eliglustat).

Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.

It is important to take Cerdelga (Eliglustat) exactly as prescribed by your doctor.

If you miss a dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

Store Cerdelga (Eliglustat) at room temperature, protect it from light and moisture, and keep it out of the reach of children.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

Before you begin using a medication, be sure to inform your doctor of any medical conditions or Allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use Cerdelga (Eliglustat).

Abnormal heart rhythms: Cerdelga (Eliglustat) can cause abnormal heart rhythms. Certain medications (e.g., Sotalol, quinidine, thioridazine, Chlorpromazine, Pimozide, moxifloxacin, Mefloquine, pentamidine, arsenic trioxide, probucol, Tacrolimus) can increase the risk of several types of abnormal heart rhythm including QT prolongation, and should not be used in combination with Cerdelga (Eliglustat). You are more at risk for this type of abnormal heart rhythm and its complications if you:

are female
are older than 65 years of age
have a family history of sudden cardiac death
have a history of heart disease or abnormal heart rhythms
have a slow heart rate
have congenital prolongation of the QT interval
have Diabetes
have had a Stroke
have low potassium, magnesium, or calcium levels
have nutritional deficiencies

If you have heart disease and abnormal heart rhythms, or are taking certain medications (e.g., Verapamil, atazanavir), discuss with your doctor how Cerdelga (Eliglustat) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Cerdelga (Eliglustat), and whether any special monitoring is needed.

Kidney Function: Cerdelga (Eliglustat) is not recommended for people with moderate to severe Kidney Disease or decreased kidney function. Cerdelga (Eliglustat) has not been studied for use by people with decreased kidney function.

Liver function: The safety and effectiveness of having decreased liver function and using Cerdelga (Eliglustat) have not been determined. Cerdelga (Eliglustat) is not recommended for people with liver disease or decreased liver function.

Pregnancy: Cerdelga (Eliglustat) should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking Cerdelga (Eliglustat), contact your doctor immediately.

Breast-feeding: It is not known if Cerdelga (Eliglustat) passes into breast milk. If you are a breast-feeding mother and are taking Cerdelga (Eliglustat), it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.

Children: The safety and effectiveness of using Cerdelga (Eliglustat) have not been established for children.

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