Lysodren (Mitotane) belongs to the group of cancer-fighting medicines known as antineoplastics. It is used to treat certain kinds of cancer that affect the adrenal cortex (the part of the body responsible for making steroid hormones like cortisol). Lysodren (Mitotane) reduces the amount of adrenocorticoid hormones produced by the adrenal cortex and affects how steroids are broken down in the body.

Lysodren (Mitotane) may be available under multiple brand names and/or in several different forms. Any specific brand name of Lysodren (Mitotane) may not be available in all of the forms or approved for all of the conditions discussed here. As well, some forms of Lysodren (Mitotane) may not be used for all of the conditions discussed here.

Your doctor may have suggested Lysodren (Mitotane) for conditions other than those listed in these drug information articles. If you have not discussed this with your doctor or are not sure why you are taking Lysodren (Mitotane), speak to your doctor. Do not stop taking Lysodren (Mitotane) without consulting your doctor.

Do not give Lysodren (Mitotane) to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take Lysodren (Mitotane) if their doctor has not prescribed it.

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The dose of Lysodren (Mitotane) depends on response to the medication and the amount of medication that can be tolerated. Usually the starting dose is 9 g to 10 g of Lysodren (Mitotane) daily in 3 or 4 equally divided doses, with or without food. Your doctor may increase the dose, depending on response, until adverse effects appear. Usually Lysodren (Mitotane) is started in the hospital until a stable dose is reached.

Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.

It is important to take Lysodren (Mitotane) exactly as prescribed by your doctor. If you miss a dose, take it as soon as possible and continue with your regular schedule. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

Store Lysodren (Mitotane) away from moisture, heat, and direct light; and keep it out of the reach of children.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.

The side effects listed below are not experienced by everyone who takes Lysodren (Mitotane). If you are concerned about side effects, discuss the risks and benefits of Lysodren (Mitotane) with your doctor.

The following side effects have been reported by at least 1% of people taking Lysodren (Mitotane). Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

• decreased appetite
• Diarrhea
• dizziness
• headache
• nausea
• tiredness or drowsiness
• vomiting

Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

• blood in urine
• confusion
• darkening of skin
• Fever
• flushing
• lethargy
• loss of appetite
• mental Depression
• muscle incoordination
• muscle weakness
• shortness of breath
• skin rash
• sweating, cold clammy skin
• tremor
• unexplained bruising
• unusual tiredness
• vision changes
• wheezing

Stop taking the medication and seek immediate medical attention if any of the following occur:

• signs of allergic reaction (swelling of the mouth, face or tongue or difficulty breathing)

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking Lysodren (Mitotane).

Automatic Refills

We manage your refills and get in touch with your doctors for prescription renewals so that you always have the medication you need.

Each one-half inch, biconvex, round, compressed white tablet, bisected on one side and impressed with "BL" over "L1" on the other side, contains Lysodren (Mitotane) 500 mg. Nonmedicinal ingredients: microcrystalline cellulose, polyethylene glycol, silicon dioxide, and starch.

Do not take Lysodren (Mitotane) if you are allergic to Lysodren (Mitotane) or any ingredients of the medication.

Personalized PocketPacks

We sort your medication into clearly labeled, individual packs so you can be sure you're taking the right dose at the right time.

There may be an interaction between Lysodren (Mitotane) and any of the following:

• Abiraterone
• alpha blockers (e.g., Alfuzosin, Doxazosin, Tamsulosin)
• amiodaroneanti-cancer medications (e.g., Docetaxel, Doxorubicin, Irinotecan, Vincristine)
• antipsychotics (e.g., Aripiprazole, Clozapine, Haloperidol)
• Apixaban
• Apremilast
• "azole" antifungals (e.g., itraconazole, ketoconazole, Voriconazole)
• benzodiazepines (e.g., Alprazolam, Clonazepam, Diazepam)
• Bisoprolol
• Buspirone
• Calcitriol
• calcium channel blockers (e.g., Amlodipine, Diltiazem, Nifedipine, Verapamil)
• cannabis
• Carbamazepine
• chloroquine
• Cobicistat
• conivaptan
• corticosteroids (e.g., beclomethasone, Dexamethasone, Prednisone)
• Cyclosporine
• Dapsone
• Darifenacin
• Disopyramide
• Dronedarone
• Enzalutamide
• estrogens (e.g., conjugated estrogen, Estradiol, ethinyl estradiol)
• Fesoterodine
• "gliptin" Diabetes medications (e.g., Linagliptin, Saxagliptin, Sitagliptin)
• hepatitis medications (e.g., asunaprevir, boceprevir, daclatasvir)
• HIV non-nucleoside reverse transcriptase inhibitors (NNRTIs; e.g., delavirdine, efavirenz, etravirine, nevirapine)
• HIV protease inhibitors (e.g., atazanavir, indinavir, ritonavir, saquinavir)
• Idelalisib
• Losartan
• macrolide antibiotics (e.g., clarithromycin, azithromycin)
• maraviroc
• Mefloquine
• Methadone
• narcotic pain relievers (e.g., Codeine, Fentanyl, Morphine, Oxycodone)
• nefazodone
• nitrates (isosorbide dinitrate, isosorbide mononitrate)
• Ondansetron
• Perampanel
• phosphodiesterase 5 inhibitors (e.g., Sildenafil, Tadalafil, Vardenafil)
• praziquantel
• Primaquine
• progestins (e.g., Dienogest, Levonorgestrel, medroxyprogesterone, Norethindrone)
• protein kinase inhibitors (e.g., Dabrafenib, Dasatinib, imatinib)
• proton pump inhibitors (e.g., Lansoprazole, Omeprazole)
• quinidine
• quinine
• rifabutin
• rivroxaban
• Roflumilast
• Romidepsin
• selective serotonin reuptake inhibitors (SSRIs; e.g., Citalopram, Fluoxetine, Paroxetine, Sertraline)
• serotonin-norepinephrine reuptake inhibitors (SNRIs; Desvenlafaxine, Duloxetine, Venlafaxine)
• Solifenacin
• Spironolactone
• "statin" anti-cholesterol medications (e.g., Atorvastatin, Lovastatin, Simvastatin)
• Tamoxifen
• Tetracycline
• Ticlopidine
• Ticagrelor
• tofactitinib
• Tolvaptan
• Trazodone
• Trimethoprim
• Ulipristal
• warfrain
• Zolpidem
• Zopiclone

If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

• stop taking one of the medications,
• change one of the medications to another,
• change how you are taking one or both of the medications, or
• leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with Lysodren (Mitotane). Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the Nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.

Before you begin taking a medication, be sure to inform your doctor of any medical conditions or Allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should take Lysodren (Mitotane).

Drowsiness/reduced alertness: Lysodren (Mitotane) may cause sedation, lethargy, or dizziness. You should exercise caution when driving, operating machinery, or performing other tasks requiring mental alertness.

Liver disease: If you have liver disease, discuss with your doctor how Lysodren (Mitotane) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Lysodren (Mitotane), and whether any special monitoring is needed.

Risk of adrenal insufficiency: Lysodren (Mitotane)'s effect on the adrenal gland may result in the need for steroid replacement therapy during times when your body is under significant stress (e.g., during surgery, trauma, or severe illness).

Pregnancy: The safety of Lysodren (Mitotane) during pregnancy has not been established. Lysodren (Mitotane) should not be used during pregnancy unless the benefits outweigh the risks.

Breast-feeding: Lysodren (Mitotane) passes into breast milk. If you are a breast-feeding mother and are taking Lysodren (Mitotane), it may affect your baby. Lysodren (Mitotane) should not be used during breast-feeding unless the benefits outweigh the risks.

Children: The safety and effectiveness of using Lysodren (Mitotane) have not been established for children under the age of 18 years.

Discreet Packaging

Your privacy is important. That's why we send your medication inside a plain delivery box so no one will know what's inside.