Before you begin using a medication, be sure to inform your doctor of any medical conditions or Allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use Apo Pravastatin.
Alcohol: People who drink large quantities of alcohol should be closely monitored by their doctor while they are taking Apo Pravastatin. Alcohol can increase the risk of developing liver problems with Apo Pravastatin. Tell your doctor if you drink more than 3 alcoholic drinks per day.
Diabetes: Pravastatin may cause an increase in blood sugar levels and glucose tolerance may change. People with diabetes may find it necessary to monitor their blood sugar more frequently while using Apo Pravastatin.
If you have diabetes or are at risk for developing diabetes, discuss with your doctor how Apo Pravastatin may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Apo Pravastatin, and whether any special monitoring is needed.
Diet: Pravastatin is not intended for use alone to reduce high cholesterol levels. It is important that a cholesterol-reducing diet along with appropriate exercise be attempted before taking any medication and continued while taking medication.
Grapefruit juice: Tell your pharmacist or doctor if you regularly drink grapefruit juice, because grapefruit juice may interact with pravastatin.
Kidney problems: If you have decreased kidney function or a history of Kidney Disease, discuss with your doctor how Apo Pravastatin may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Apo Pravastatin, and whether any special monitoring is needed.
Liver function: Pravastatin may reduce liver function and can cause liver failure. Laboratory signs of harmful effects to the liver occur in about 0.5% of adults who take pravastatin for extended periods. When the medication is stopped, the laboratory tests usually slowly return to normal.
Your doctor may want to test your liver function regularly with blood tests while you are taking Apo Pravastatin. Apo Pravastatin should not be used by people with active liver disease or by people whose liver function tests are higher than normal. If you have a history of liver disease, discuss with your doctor how Apo Pravastatin may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Apo Pravastatin, and whether any special monitoring is needed.
If you experience symptoms of liver problems such as fatigue, feeling unwell, loss of appetite, nausea, yellowing of the skin or whites of the eyes, dark urine, pale stools, abdominal pain or swelling, and itchy skin, contact your doctor immediately.
Lung inflammation: Lung inflammation (interstitial lung disease), causing difficulty breathing has occurred rarely in some people taking Apo Pravastatin. This complication can be serious and sometimes fatal. If you experience new or worsening shortness of breath or cough (with or without fever) at any time while you are taking pravastatin, contact your doctor immediately.
Muscle effects: In rare cases, serious muscle damage has been associated with the use of statin medications (i.e., cholesterol-lowering medications whose names end in "-statin," such as Atorvastatin, Fluvastatin, Lovastatin, pravastatin, Rosuvastatin, or Simvastatin), especially at higher doses. Before taking Apo Pravastatin, tell your doctor or pharmacist if you:
- are over the age of 65
- are taking other medications, including prescription, non-prescription and natural health products, as drug interactions are possible
- are taking other cholesterol-lowering medication such as fibrates (Gemfibrozil, Fenofibrate) or Niacin
- are physically frail
- do excessive physical exercise
- have diabetes
- have a family history of muscular disorders
- have kidney or liver problems
- have uncontrolled Thyroid problems
- have undergone surgery or other tissue injury
- have had any past problems with the muscles (pain, tenderness), after using a statin
- regularly drink three or more alcoholic drinks daily
Report any unexplained muscle pain, tenderness, weakness, cramps, or any brown or discoloured urine to your doctor immediately, particularly if you are also experiencing malaise (a general feeling of being unwell) or fever.
Pregnancy: Apo Pravastatin should not be taken during pregnancy, as it may cause harm to the developing baby. If you become pregnant while taking Apo Pravastatin, stop taking it immediately and contact your doctor.
Apo Pravastatin should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking Apo Pravastatin, stop taking it immediately and contact your doctor.
Breast-feeding: Apo Pravastatin passes into breast milk. If you are a breast-feeding mother and are taking pravastatin, it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.
Children: There is limited experience with the use of Apo Pravastatin by children. The safety and effectiveness of using Apo Pravastatin have not been established for children under 16 years old.
Seniors: If you are over 65 years old, your doctor will likely monitor you closely for muscle-related side effects.
