Ofev (Nintedanib) belongs to the class of medications called protein kinase inhibitors. It is used to treat idiopathic Pulmonary Fibrosis (IFP) – a condition that causes scarring of the lungs for no apparent reason. As a result, the lining of the lungs becomes thicker, making it more difficult to breathe. Ofev (Nintedanib) does not cure IFP, however it slows down how quickly the illness progresses.  

Ofev (Nintedanib) is also used to treat chronic fibrosing interstitial lung diseases – diseases that cause scarring and inflammation in the lungs – where lung scarring continues to worsen. It is also used to treat certain types of interstitial lung disease associated with systemic sclerosis, an autoimmune disorder, by slowing down the decrease in lung function.

Ofev (Nintedanib) works by blocking the effects of some of the substances that cause scarring of the lungs.

Ofev (Nintedanib) may be available under multiple brand names and/or in several different forms. Any specific brand name of Ofev (Nintedanib) may not be available in all of the forms or approved for all of the conditions discussed here. As well, some forms of Ofev (Nintedanib) may not be used for all of the conditions discussed here.

Your doctor may have suggested Ofev (Nintedanib) for conditions other than those listed in these drug information articles. If you have not discussed this with your doctor or are not sure why you are taking Ofev (Nintedanib), speak to your doctor. Do not stop taking Ofev (Nintedanib) without consulting your doctor.

Do not give Ofev (Nintedanib) to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take Ofev (Nintedanib) if their doctor has not prescribed it.

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We sort your medication into clearly labeled, individual packs so you can be sure you're taking the right dose at the right time.

The recommended dose of Ofev (Nintedanib) is 150 mg taken twice a day. The doses should be taken approximately 12 hours apart. The capsules should be taken with food to reduce possible upset stomach. Swallow the capsules whole, with water. Do not crush or chew the capsule.

Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.

It is important to take Ofev (Nintedanib) exactly as prescribed by your doctor.

If you miss a dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

Store Ofev (Nintedanib) at room temperature, in the original blister packaging to protect it from light and moisture. Keep Ofev (Nintedanib) out of sight and reach of children.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.

The side effects listed below are not experienced by everyone who takes Ofev (Nintedanib). If you are concerned about side effects, discuss the risks and benefits of Ofev (Nintedanib) with your doctor.

The following side effects have been reported by at least 1% of people taking Ofev (Nintedanib). Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

• Constipation
• decreased appetite
• dizziness
• gas
• hair loss
• headache
• heartburn
• itchy skin
• muscle pain
• nausea
• rash
• stomach pain
• weight loss

Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

• Diarrhea
• increased blood pressure
• signs of clotting problems (e.g., unusual nosebleeds, bruising, blood in urine, coughing blood, bleeding gums, cuts that don't stop bleeding)
• signs of dehydration (e.g., decreased urine, dry skin, dry and sticky mouth, sleepiness, dizziness, headache, thirst, confusion)
• signs of liver problems (e.g., nausea, vomiting, diarrhea, loss of appetite, weight loss, yellowing of the skin or whites of the eyes, dark urine, pale stools)
• vomiting

Stop taking the medication and seek immediate medical attention if any of the following occur:

• signs of an Aneurysm (e.g., cough, coughing up blood, strong pain high in the neck or back, pulsing sensation in the chest or abdomen, problems swallowing, hoarseness)
• signs of bleeding in the stomach (e.g., bloody, black, or tarry stools; spitting up of blood; vomiting blood or material that looks like coffee grounds)
• signs of a Heart Attack (e.g., chest pain or pressure, pain extending through shoulder and arm, nausea and vomiting, sweating)
• signs of pancreatitis (e.g., abdominal pain on the upper left side, back pain, nausea, Fever, chills, rapid heartbeat, swollen abdomen)
• symptoms of an artery dissection (e.g., sudden severe pain in the back, chest, or abdomen)

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking Ofev (Nintedanib).

Automatic Refills

We manage your refills and get in touch with your doctors for prescription renewals so that you always have the medication you need.

100 mg
Each peach-coloured, opaque, oblong soft-gelatin capsule, imprinted on one side in black with the Boehringer Ingelheim company symbol and "100", contains 100 mg of Ofev (Nintedanib). Nonmedicinal ingredients: medium chain triglycerides, hard fat, soya lecithin (E322); capsule shell: gelatin, glycerol 85 %, titanium dioxide (E171), iron oxide red (E172), iron oxide yellow (E172), black ink (Opacode®); black ink: shellac glaze, iron oxide black (E172), propylene glycol (E1520).

150 mg
Each brown, opaque, oblong soft-gelatin capsule, imprinted on one side in black with the Boehringer Ingelheim company symbol and "150" contains 150 mg of Ofev (Nintedanib). Nonmedicinal ingredients: medium chain triglycerides, hard fat, soya lecithin (E322); capsule shell: gelatin, glycerol 85 %, titanium dioxide (E171), iron oxide red (E172), iron oxide yellow (E172), black ink (Opacode®); black ink: shellac glaze, iron oxide black (E172), propylene glycol (E1520).

Do not Ofev (Nintedanib) if you:

• are allergic to Ofev (Nintedanib) or any ingredients of the medication
• are allergic to peanuts or soya
• are pregnant

Free Delivery

Your medication is delivered directly to you at no added cost. We even offer same-day delivery in select locations.

There may be an interaction between Ofev (Nintedanib) and any of the following:

• anticoagulants (e.g., Dalteparin, Enoxaparin, warfarin, Apixaban, dabigatran, Rivaroxaban, warfarin)
• Apalutamide
• "azole" antifungals (e.g., itraconazole, ketoconazole, Voriconazole)
• Carbamazepine
• Cobicistat
• conivaptan
• Dronedarone
• Enzalutamide
• grapefruit juice
• Heparin
• HIV protease inhibitors (e.g., atazanavir, indinavir, ritonavir, saquinavir)
• Letrozole
• lumacaftor and Ivacaftor
• macrolide antibiotics (e.g., clarithromycin, erythromycin)
• Phenobarbital
• Phenytoin
• other protein kinase inhibitors (e.g., Crizotinib, Dabrafenib, imatinib, Lapatinib, Nilotinib, Sunitinib)
• rifampin
• rifabutin
• tobacco (smoked)
• St. John's wort
• Verapamil

If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

• stop taking one of the medications,
• change one of the medications to another,
• change how you are taking one or both of the medications, or
• leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with Ofev (Nintedanib). Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the Nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.

Before you begin using a medication, be sure to inform your doctor of any medical conditions or Allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use Ofev (Nintedanib).

Birth control: Effective birth control must be used during treatment and for at least 3 months after stopping therapy. If you are using birth control pills or another form of hormonal birth control, you should also use a barrier method, such as condoms. Tell your doctor immediately if you become pregnant while using Ofev (Nintedanib).

Bleeding problems: Ofev (Nintedanib) may increase your risk of bleeding. This risk may be greater if you are taking medications such as Warfarin or if you have bleeding problems. If you develop unexplained bruising, nosebleeds, dark or tarry stools, or start coughing up blood, contact your doctor immediately or seek immediate medical attention.

Blood pressure: Ofev (Nintedanib) may cause increased blood pressure. If you have a history of blood pressure problems, discuss with your doctor how Ofev (Nintedanib) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Ofev (Nintedanib), and whether any special monitoring is needed.

Diarrhea: Many people who take Ofev (Nintedanib) experience mild-to-moderate diarrhea. Diarrhea causes fluid loss from the body and can contribute to other side effects of Ofev (Nintedanib). If you experience diarrhea while taking Ofev (Nintedanib), contact your doctor as soon as possible.

Gastrointestinal perforation: Ofev (Nintedanib) has also been linked to serious digestive system problems, including gastrointestinal perforation (a tear or hole in the wall of the digestive tract). People who are taking corticosteroids or non-steroidal anti-inflammatory medications, have had recent abdominal surgery, or have had digestive system problems may be at increased risk of experiencing gastrointestinal perforation.

If you experience symptoms of a gastrointestinal perforation, such as severe stomach pain, fever, chills, nausea, or vomiting, seek immediate medical attention.

Heart problems: Ofev (Nintedanib) may affect your heart function and cause heart problems such as heart attack, decreased oxygen supply to the heart, heart failure, and a slow heart rate. Get immediate medical attention if you experience shortness of breath, sudden chest pain, or an extremely slow heart rate. If you have a history of heart problems, discuss with your doctor how Ofev (Nintedanib) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Ofev (Nintedanib), and whether any special monitoring is needed.

Liver problems: Decreased liver function or liver disease may cause Ofev (Nintedanib) to build up in the body, causing side effects. Ofev (Nintedanib) has not been studied for people who have moderate-to-severe liver problems and may itself cause liver problems. If you have decreased liver function, discuss with your doctor how Ofev (Nintedanib) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Ofev (Nintedanib), and whether any special monitoring is needed.

If you experience symptoms of liver problems such as fatigue, feeling unwell, loss of appetite, nausea, yellowing of the skin or whites of the eyes, dark urine, pale stools, abdominal pain or swelling, and itchy skin, contact your doctor immediately.

Wound healing: Ofev (Nintedanib) may affect the way wounds heal. If you are having surgery, a dental procedure, or have recently had surgery, let your doctor know. You may need to temporarily stop taking Ofev (Nintedanib). Your doctor will tell you when you can restart the medication.

Pregnancy: Ofev (Nintedanib) should not be used during pregnancy, as it may cause harm to the developing baby if it is taken by the mother while pregnant. If you become pregnant while taking Ofev (Nintedanib), contact your doctor immediately.

Breast-feeding: It is not known if Ofev (Nintedanib) passes into breast milk. If you are breast-feeding and are taking Ofev (Nintedanib), it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.

Children: The safety and effectiveness of using Ofev (Nintedanib) have not been established for children.

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