Vitrakvi

Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.

The side effects listed below are not experienced by everyone who takes Vitrakvi (Larotrectinib). If you are concerned about side effects, discuss the risks and benefits of Vitrakvi (Larotrectinib) with your doctor.

The following side effects have been reported by at least 1% of people taking Vitrakvi (Larotrectinib). Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

• abdominal pain
• Constipation
• cough
• Diarrhea
• dizziness
• fatigue
• Fever
• headache
• loss of appetite
• muscle and joint aches or pain
• nausea
• shortness of breath
• stuffy nose
• swelling or pain in the arms, legs, hands, or feet
• vomiting
• weakness
• weight gain

Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

• anxiety
• balance problems
• blood in the urine
• change in mental status, ability to concentrate
• difficulty speaking
• difficulty walking normally
• falls
• high blood pressure
• memory problems
• numbness or tingling in hands and feet
• signs of Anemia (low red blood cells; e.g., dizziness, pale skin, unusual tiredness or weakness, shortness of breath)
• signs of dehydration (e.g., decreased urine, dry skin, dry and sticky mouth, sleepiness, dizziness, headache, thirst, confusion)
• signs of infection (symptoms may include fever or chills, severe diarrhea, shortness of breath, prolonged dizziness, headache, stiff neck, weight loss, or listlessness)
• signs of liver problems (e.g., nausea, vomiting, diarrhea, loss of appetite, weight loss, yellowing of the skin or whites of the eyes, dark urine, pale stools)
• signs of clotting problems (e.g., unusual nosebleeds, bruising, blood in urine, coughing blood, bleeding gums, cuts that don't stop bleeding)
• signs of low potassium levels in the blood (e.g., weakness, fatigue, muscle cramps, irregular heartbeat)
• signs of low sodium levels in the blood (e.g., achy, stiff, or uncoordinated muscles; confusion; tiredness; weakness)
• signs of a skin infection (heat, redness, pain or tenderness on an area of skin)
• symptoms of low blood sugar (e.g., cold sweat, cool pale skin, headache, fast heartbeat, weakness)
• tremor

Stop taking the medication and seek immediate medical attention if any of the following occur:

• delirium
• signs of Stroke (e.g., sudden or severe headache; sudden loss of coordination; vision changes; sudden slurring of speech; or unexplained weakness, numbness, or pain in arm or leg)
• symptoms of blood infection (e.g., high fever, shaking, chills, weakness, fast heartbeat, fast breathing)

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking Vitrakvi (Larotrectinib).