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Inspra

Inspra

(eplerenone)

Inspra (Eplerenone) belongs to a group of medications called aldosterone antagonists. It is used in combination with other medications to treat heart failure and help prevent worsening heart failure after a Heart Attack, thereby improving the chances of survival.

Available form

Dosage

Tablet

25MG, 50MG

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Inspra information

Dosage

Side Effects

Available Form

Contraindications

Precautions

Warnings

To treat heart failure or prevent heart failure after a heart attack, the recommended starting dose is 25 mg given once daily. It is usually increased by your doctor to 50 mg once daily, within 4 weeks. Inspra (Eplerenone) is usually started within 2 weeks of a heart attack.

For treating high blood pressure, the starting dose of Inspra (Eplerenone) is 50 mg taken once daily. If your blood pressure has not come down enough after 4 weeks, your doctor may increase the dose of Inspra (Eplerenone) to 50 mg taken two times a day.

Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.

Inspra (Eplerenone) can be taken with or without food. Swallow the tablets with water and without chewing.

It is important that Inspra (Eplerenone) be taken exactly as prescribed by your doctor. If you miss a dose, take it as soon as possible and continue with your regular schedule. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose for to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

Store Inspra (Eplerenone) at room temperature and keep it out of the reach of children.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.

The side effects listed below are not experienced by everyone who takes Inspra (Eplerenone). If you are concerned about side effects, discuss the risks and benefits of Inspra (Eplerenone) with your doctor.

The following side effects have been reported by at least 1% of people taking Inspra (Eplerenone). Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

dehydration (i.e., Headaches, dizziness, or fainting)
dizziness when getting up from a sitting or lying position (Low Blood Pressure)
headache
heartburn
indigestion

Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not check with your doctor or seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

Angina or chest pain
difficulty breathing
fainting
increased levels of potassium in the blood (e.g., irregular heartbeat, slowed heart rate, nausea)
shortness of breath or difficulty breathing
signs of a blood clot in blood vessels, such as sudden vision change or dizziness, chest pain, pain and swelling in the leg muscle
signs of heart rhythm changes (e.g., dizziness, fainting, rapid heartbeat, pounding heartbeat)
signs of liver problems (e.g., nausea, vomiting, Diarrhea, loss of appetite, weight loss, yellowing of the skin or whites of the eyes, dark urine, pale stools)
signs of pancreatitis (e.g., abdominal pain on the upper left side, back pain, nausea, Fever, chills, rapid heartbeat, swollen abdomen)
signs of urinary tract infection (e.g., painful or difficult urination or a decrease in the amount of urine)
symptoms of Hypothyroidism - underactive Thyroid gland (e.g., dry skin, Constipation, weight gain, fatigue, aches, pains and stiffness, intolerance to cold, Depression, memory problems)
trouble swallowing
weight gain

Stop taking the medication and seek immediate medical attention if any of the following occur:

signs of a heart attack (e.g., chest pain, shoulder pain, difficulty breathing, dizziness)
signs of heart failure (e.g., fast or irregular heartbeat; swelling of lower legs, feet, and abdomen; wheezing; trouble breathing; or shortness of breath)
symptoms of an allergic reaction (e.g., swelling of the hands, feet, ankles, face, lips, mouth, or throat; difficulty breathing or swallowing)

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking Inspra (Eplerenone).

Before you begin using a medication, be sure to inform your doctor of any medical conditions or Allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use Inspra (Eplerenone).

Diabetes: People with diabetes that have heart failure after a heart attack, especially those who have proteinuria (protein in the urine), appear to have a higher rate of hyperkalemia (high blood potassium; see below). If you have diabetes, discuss with your doctor how Inspra (Eplerenone) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Inspra (Eplerenone), and whether any special monitoring is needed.

Kidney problems: The safety of Inspra (Eplerenone) when used to treat people with moderate-to-severe kidney dysfunction has not been determined. These people should not take Inspra (Eplerenone).

If you have reduced kidney function or Kidney Disease, discuss with your doctor how Inspra (Eplerenone) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Inspra (Eplerenone), and whether any special monitoring is needed.

Liver function: Liver disease or reduced liver function may cause Inspra (Eplerenone) to build up in the body, causing side effects.

If you have liver problems, discuss with your doctor how Inspra (Eplerenone) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Inspra (Eplerenone), and whether any special monitoring is needed.

The safety of Inspra (Eplerenone) when used to treat people with severe liver dysfunction has not been determined. These people should not take Inspra (Eplerenone).

Potassium levels: Too much potassium in the blood (hyperkalemia) is one of the most common risks of Inspra (Eplerenone). Hyperkalemia that is not recognized and treated can cause serious heart rhythm problems, which can sometimes be fatal. Your doctor will monitor your potassium levels before starting Inspra (Eplerenone), during the first week of taking Inspra (Eplerenone), and periodically throughout your therapy.

Do not take potassium supplements (including dietary potassium) or salt substitutes at the same time as Inspra (Eplerenone) unless directed to do so by your doctor. If you experience an irregular, slow, or weak heartbeat, contact your doctor as soon as possible.

Pregnancy: Inspra (Eplerenone) should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking Inspra (Eplerenone), contact your doctor immediately.

Breast-feeding: It is not known if Inspra (Eplerenone) passes into breast milk. If you are a breast-feeding mother and are taking Inspra (Eplerenone), it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.

Children: The safety and effectiveness of using Inspra (Eplerenone) have not been established for children. Inspra (Eplerenone) is not recommended for children.

Seniors: People over the age of 65 may be at increased risk of experiencing side effects from this mediation as a result of decreased kidney function. Doses for seniors may start lower and increase more slowly than for other adults.

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