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Heparin Leo

Heparin Leo

(heparin)

Heparin is a member of the group of medications known as anticoagulants. Anticoagulants reduce the clotting ability of the blood and so prevent harmful Blood Clots from forming in blood vessels.

Available form

Dosage

Injectable

1000IU/ML

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Heparin Leo information

Dosage

Side Effects

Available Form

Contraindications

Precautions

Warnings

Heparin is given by injection. It can be injected under the skin (subcutaneously) or given into a vein by a procedure called intravenous infusion. The recommended dose and route of administration of heparin varies according to the individual and the condition being treated. Your doctor will choose the dose that is most likely to prevent blood clots but not cause you to bleed easily.

Doses of heparin vary on an individual basis. People taking heparin will need to be monitored by taking blood tests scheduled by their health care provider in order to make sure that they receive the proper amount of medication.

Many things can affect the dose or schedule of medication that a person needs, such as body weight, other medical conditions, and other medications. If the schedule or dose of your medication is different from the ones listed above, do not change the way that you use the medication without consulting your doctor.

It is important to use Heparin Leo exactly as prescribed by your doctor. If you miss an injection, take it as soon as possible and continue with your regular schedule. If it is almost time for your next injection, skip the missed dose and continue with your regular dosing schedule. Do not inject a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

Store Heparin Leo at room temperature, protect it from heat, and keep it out of the reach of children. If you are using the multiple dose vial, discard any remaining medication in the vial 28 days after the first use.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.

The side effects listed below are not experienced by everyone who takes Heparin Leo. If you are concerned about side effects, discuss the risks and benefits of this medication with your doctor.

The following side effects have been reported by at least 1% of people taking Heparin Leo. Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

bleeding
decreased level of platelets (which should be monitored while on heparin)
irritation at the injection site

Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

bleeding from the gums when brushing your teeth
blood in urine
heavy bleeding or oozing from cuts or wounds
itching and burning of soles of feet
loss of hair affecting the entire scalp or confined to the temple
painful erection
signs of internal bleeding (vomiting blood)
unexplained bruising or purplish areas on the skin
unexplained nosebleeds
unusually heavy or unexpected menstrual bleeding

Stop taking the medication and seek immediate medical attention if any of the following occur:

chest pain
signs of bleeding in the stomach (e.g., bloody, black, or tarry stools, spitting up of blood, vomiting blood or material that looks like coffee grounds)
signs of a Anaphylaxis (severe allergic reaction) (such as difficulty breathing; skin rash or Hives; swelling of the lips, mouth, or throat)

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking Heparin Leo.

There may be an interaction between heparin and any of the following:

5-ASA medications (e.g., Mesalamine, olsalzine, Sulfasalazine)
acetylsalicylic acid (Asa)
Aliskiren
angiotensin-converting-enzyme inhibitors (ACEIs; Captopril, Ramipril)
angiotensin receptor blockers (ARBs; e.g., candasartan, Irbesartan, Losartan)
Apixaban
Canagliflozin
Clopidogrel
dabigatran
Dasatinib
Deferasirox
Edoxaban
Eplerenone
estrogens (e.g., conjugated estrogen, Estradiol, ethinyl estradiol)
herbal products that affect blood clotting (e.g., cat's claw, chamomile, fenugreek, evening primrose, feverfew, garlic, ginger, ginseng, turmeric)
Nitroglycerin
non-steroidal anti-inflammatory medications (NSAIDs; e.g., Diclofenac, Ibuprofen, Naproxen)
Obinutuzumab
omega-3 fatty acids
Pentoxifylline
potassium supplements
Prasugrel
progestins (e.g., Dienogest, Levonorgestrel, medroxyprogesterone, Norethindrone)
Rivaroxaban
selective serotonin reuptake inhibitors (SSRIs; e.g., Citalopram, Fluoxetine, Paroxetine, Sertraline)
serotonin-norepinephrine reuptake inhibitors (SNRIs; Desvenlafaxine, Duloxetine, Venlafaxine)
Ticagrelor
Ticlopidine
tipranavir
vitamin E
Warfarin

If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

stop taking one of the medications,
change one of the medications to another,
change how you are taking one or both of the medications, or
leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with Heparin Leo. Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the Nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.

Before you begin using a medication, be sure to inform your doctor of any medical conditions or Allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use Heparin Leo.

Blood clotting: Heparin Leo is intended to prevent unwanted blood clots, but it can make you bleed more easily. You should be careful when performing activities that increase your risk of bleeding. Tell your doctor of any signs that your blood is not clotting as quickly as usual. Such symptoms may include black and tarry stools, blood in the urine, easy bruising, or cuts that won't stop bleeding.

Kidney problems: If you have kidney problems, discuss with your doctor how Heparin Leo may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Heparin Leo, and whether any special monitoring is needed.

Liver problems: If you have liver problems, discuss with your doctor how Heparin Leo may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Heparin Leo, and whether any special monitoring is needed.

Medical conditions: Heparin increases the risk of bleeding complications for many people with ongoing medical conditions. If you have subacute bacterial Endocarditis, blood or blood vessel disorders, severe high blood pressure, indwelling catheters, inaccessible gastrointestinal ulcers, Ulcerative Colitis, continuous tube drainage of stomach or small intestine, or menstruation, discuss with your doctor how Heparin Leo may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Heparin Leo, and whether any special monitoring is needed.

Osteoporosis: People who receive long-term, daily doses of heparin should be monitored by their doctor for possible development of osteoporosis (brittle bones) or fractures.

Pregnancy: Although heparin is the anticoagulant (blood-thinner) of choice during pregnancy, caution needs to be exercised due to risk of bleeding, especially during the third trimester and immediately after the birth. If you become pregnant while taking Heparin Leo, contact your doctor immediately.

Breast-feeding: Heparin does not pass into breast milk; however, the preservative in some of the multi-dose vials, benzyl alcohol, does pass into breast milk. Benzyl alcohol can cause complications for newborn, premature, or low-birth-weight infants. If you are a breast-feeding mother and are taking heparin, it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.

Seniors: Seniors may be at an increased risk of bleeding while using heparin. Your doctor will adjust your dose accordingly.

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