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Daklinza

Daklinza

Daclatasvir belongs to the class of medications called antiviral agents. Daklinza is used by adults, in combination with other antiviral medications to treat chronic (long-term), Hepatitis C virus infections with hepatitis C genotypes 1, 2, or 3.

Available form

Dosage

Tablet

30MG

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Daklinza information

Dosage

Side Effects

Available Form

Contraindications

Precautions

Warnings

The recommended adult dose of daclatasvir is 60 mg taken by mouth once a day. It must be taken with another antiviral medication such as sofosbuvir. Ribavirin may also be added to this combination, however daclatasvir should not be taken with only ribavirin. Depending on the type of hepatitis C virus you have and other characteristics of your illness, your doctor may recommend that you take Daklinza for 12 to 24 weeks.

Daclatasvir may be taken with food or on an empty stomach.

Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.

It is important to take Daklinza exactly as prescribed by your doctor. If you miss a dose, and remember less than 20 hours after the scheduled dose, take it as soon as possible and continue with your regular schedule. If it is less than 4 hours until your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

Store Daklinza at room temperature in the original container. Protect it from light and moisture, and keep it out of the reach of children.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

There may be an interaction between daclatasvir and any of the following:

Aliskiren
Amiodarone
anticancer medications (e.g., Doxorubicin, Etoposide, Idarubicin, Irinotecan, Paclitaxel)
antihistamines (e.g., bilastine, cetirizine, Desloratadine, Loratadine)
antipsychotics (e.g., Haloperidol, Paliperidone, Risperidone)
Aprepitant
Bosentan
Buprenorphine
calcium channel blockers (e.g., Amlodipine, Diltiazem, Nifedipine, Verapamil)
carbamazepine
Carvedilol
Cobicistat
Colchicine
conivaptan
Cyclosporine
dabigatran
Deferasirox
dexamethasone
diabetes medications (e.g., chlorpropamide, Glyburide, insulin, Metformin, Rosiglitazone)
Digoxin
Dronedarone
Edoxaban
Elagolix
Enzalutamide
Eslicarbazepine
estrogens (e.g., conjugated estrogen, Estradiol, ethinyl estradiol)
Everolimus
grapefruit juice
other hepatitis C antivirals (e.g., grazoprevir, ledipasvir, voxilaprevir)
HIV non-nucleoside reverse transcriptase inhibitors (NNRTIs; e.g., delavirdine, efavirenz, etravirine, nevirapine)
HIV protease inhibitors (e.g., atazanavir, indinavir, ritonavir, saquinavir)
Hydrocortisone
ivermectin
Lomitapide
Loperamide
lumacaftor
macrolide antibiotics (e.g., clarithromycin, erythromycin)
Methotrexate
mifepristone
Mitotane
Modafinil
Morphine
Nadolol
Naloxegol
Norfloxacin
Ondansetron
phenobarbital
phenytoin
primidone
certain protein kinase inhibitors (e.g., Bosutinib, Dabrafenib, Dasatinib, imatinib, Pazopanib)
Prucalopride
quinidine
quinine
Ranitidine
rifabutin
rifampin
rifaximin
Riociguat
Rivaroxaban
Romidepsin
St. John's wort
Silodosin
siltuximab
Sirolimus
"statin" anti-cholesterol medications (e.g., Atorvastatin, Lovastatin, Simvastatin)
Stiripentol
Tacrolimus
Tocilizumab
Tolvaptan
Warfarin

If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

stop taking one of the medications,
change one of the medications to another,
change how you are taking one or both of the medications, or
leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with Daklinza. Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the Nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.

Before you begin using a medication, be sure to inform your doctor of any medical conditions or Allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use Daklinza.

Diabetes: People with diabetes may experience loss of glucose control while taking daclatasvir. This may mean your blood glucose levels are unusually high or low. If you have diabetes, discuss with your doctor how Daklinza may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this mediation, and whether any special monitoring is needed. You should testing your blood glucose level more frequently while you are taking Daklinza.

Galactose intolerance: Daclatasvir is prepared with lactose. If you have lactose or galactose intolerance you should not take Daklinza.

Hepatitis B reactivation: People who have hepatitis B infection that is dormant may experience the infection returning, causing further liver dysfunction or liver failure. If you have a history of hepatitis B infection, discuss with your doctor how Daklinza may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this mediation, and whether any special monitoring is needed.

If you experience symptoms of worsening liver function, such as fatigue, feeling unwell, loss of appetite, nausea, yellowing of the skin or whites of the eyes, dark urine, pale stools, abdominal pain or swelling, and itchy skin, contact your doctor immediately.

Pregnancy: If you are not taking ribavirin, talk to your doctor about birth control. Effective birth control should be used while you are taking daclatasvir and for at least 5 weeks after stopping Daklinza.

Daklinza should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking Daklinza, contact your doctor immediately.

Breast-feeding: It is not known if daclatasvir passes into breast milk. If you are a breast-feeding mother and are taking Daklinza, it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.

Children: The safety and effectiveness of using Daklinza have not been established for children.

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