Before you begin using a medication, be sure to inform your doctor of any medical conditions or Allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use Xospata (Gilteritinib).
Birth control: Women and men who are taking Xospata (Gilteritinib) should use effective birth control. Women should use effective birth control while taking Xospata (Gilteritinib) and for at least 6 months after taking the last dose. Men taking Xospata (Gilteritinib) and whose partners may become pregnant should use effective birth control while taking Xospata (Gilteritinib) and for at least 4 months after taking the last dose.
Driving: Xospata (Gilteritinib) can cause severe dizziness or fainting which may affect your ability to safely drive or operate machinery. Do not drive or perform hazardous tasks such as operating machinery until you know how Xospata (Gilteritinib) affects you.
Grapefruit juice: Grapefruit juice affects how Xospata (Gilteritinib) is removed from the body and may cause the medication to build up in the body, causing side effects. Do not drink grapefruit juice while taking Xospata (Gilteritinib).
Heart rhythm: Xospata (Gilteritinib) can cause changes to the normal rhythm of the heart, including an irregular heartbeat called QT prolongation. QT prolongation is a serious life-threatening condition that can cause fainting, seizures, and sudden death. If you are at risk for heart rhythm problems (e.g., people with heart failure, Angina, low potassium or magnesium levels), discuss with your doctor how Xospata (Gilteritinib) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Xospata (Gilteritinib), and whether any special monitoring is needed.
Liver function: If you have liver problems, discuss with your doctor how Xospata (Gilteritinib) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Xospata (Gilteritinib), and whether any special monitoring is needed.
Pancreatitis: Xospata (Gilteritinib) can cause the pancreas to become inflamed. If you have a history of pancreatitis, discuss with your doctor how Xospata (Gilteritinib) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Xospata (Gilteritinib), and whether any special monitoring is needed.
Report signs of pancreatitis such as abdominal pain on the upper left side, back pain, nausea, fever, chills, rapid heartbeat, or swollen abdomen to your doctor immediately.
Posterior reversible leukoencephalopathy syndrome (PRES): This is a rare disease of the brain that may occur when using medications like Xospata (Gilteritinib). Make sure your doctor knows if you have experienced this before. If you experience signs and symptoms of RPLS, such as headache, seizures, change in awareness or consciousness, or vision changes, contact your doctor immediately.
Respiratory problems: Cases of severe inflammation of the lung and heart have been reported with Xospata (Gilteritinib). These lung and heart problems can be life-threatening and should be considered a medical emergency. If you experience fever, shortness of breath, swelling of the ankles and feet, sudden weight gain, or painful breathing, seek immediate medical attention.
Pregnancy: Xospata (Gilteritinib) should not be used during pregnancy due to the risk that it may cause harm to the unborn baby. If you become pregnant while taking Xospata (Gilteritinib), contact your doctor immediately.
Breast-feeding: It is not known if Xospata (Gilteritinib) passes into breast milk. If you are a breast-feeding mother and are taking Xospata (Gilteritinib), it may affect your baby. Women are advised to avoid breast-feeding while taking Xospata (Gilteritinib) and for 2 months after taking the last dose.
Children: The safety and effectiveness of using Xospata (Gilteritinib) have not been established for children.