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Posanol

Posanol

Posaconazole belongs to the class of medications called antifungals. It is used to prevent certain serious fungal infections for people 13 years of age and older whose immune systems may be weakened by other medications or diseases.

Available form

Dosage

Suspension

40MG/ML

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Posanol information

Dosage

Side Effects

Available Form

Contraindications

Precautions

Warnings

Proper use of posaconazole depends on which formulation of the medication you are taking. Do not switch between taking posaconazole oral suspension and the posaconazole delayed-release tablets without talking to your doctor. The dosing between the suspension and the delayed-release tablets is different.

[Delayed-release tablets]

To prevent serious fungal infections, the recommended dose of posaconazole is 300 mg (3 tablets of 100 mg) twice daily on the first day, then 300 mg (3 tablets of 100 mg) taken once daily thereafter.

For certain fungal infections that have not responded to other medications or when other medications have caused side effects, the recommended dose of posaconazole is 300 mg (3 tablets of 100 mg) twice daily on the first day, then 300 mg (3 tablets of 100 mg) taken once daily thereafter. Posaconazole delayed-release tablets should be swallowed whole. They may be taken with or without food. Do not crush, chew, break or dissolve the tablets as this will destroy the time-release property of Posanol.

Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.

Your doctor will determine how long the duration of your treatment will be. It is important to use Posanol exactly as prescribed by your doctor. Finish all Posanol, even if you have started to feel better.

If you miss a dose, take it as soon as possible and continue with your regular schedule. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

Store Posanol at room temperature, do not allow it to freeze, and keep it out of the reach of children.

[Oral suspension]

To prevent serious fungal infections, the recommended dose of posaconazole oral suspension is 200 mg (5 mL) taken 3 times daily.

For certain fungal infections that have not responded to other medications or when other medications have caused side effects, the recommended dose of posaconazole oral suspension is 400 mg (10 mL) taken twice daily.

For the treatment of thrush, the recommended dose of posaconazole oral suspension is 100 mg (2.5 mL) taken twice daily on the first day, then 100 mg (2.5 mL) taken once daily thereafter.

Posaconazole oral suspension should be given with a meal or nutritional supplement (if food is not tolerated) to help the medication get absorbed into the body. If you are not able to take meals or nutritional supplements your doctor may recommend that you take a dose of 200 mg (5 mL) 4 times daily.

When taking the oral suspension, use the measuring spoon that is provided to measure each dose, as it gives a more accurate measurement than household teaspoons.

Shake the bottle well before each use. The suspension should be used within 4 weeks of opening the bottle. Safely discard any suspension that remains. Store Posanol at room temperature, do not allow it to freeze, and keep it out of the reach of children.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.

The side effects listed below are not experienced by everyone who takes Posanol. If you are concerned about side effects, discuss the risks and benefits of Posanol with your doctor.

The following side effects have been reported by at least 1% of people taking Posanol. Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

Diarrhea
dizziness
Dry Mouth
fatigue
Fever
gas
headache
loss of appetite
nausea
numbness, prickling, or tingling sensations
skin rash
sleepiness
tremor
upset stomach
vomiting
weakness

Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

abnormal heart rhythms (e.g., very fast or slow heartbeat)
signs of clotting problems (e.g., unusual nosebleeds, bruising, blood in urine, coughing blood, bleeding gums, cuts that don’t stop bleeding)
signs of infection (symptoms may include fever or chills, severe diarrhea, shortness of breath, prolonged dizziness, headache, stiff neck, weight loss, or listlessness)
signs of liver problems (e.g., yellowing of the skin or eyes, flu-like symptoms, fatigue, abdominal pain, light coloured stools, nausea, vomiting)

Stop taking the medication and seek immediate medical attention if any of the following occur:

signs of a Anaphylaxis (severe allergic reaction) (e.g., Hives; skin blistering or peeling; difficulty breathing; swelling of the face, throat, or tongue)

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking Posanol.

Before you begin using a medication, be sure to inform your doctor of any medical conditions or Allergies you may have, any medications you are taking, whether you are pregnant or breastfeeding, and any other significant facts about your health. These factors may affect how you should use Posanol.

Abnormal heart rhythms: Posanol can increase the risk of abnormal heart rhythms. Certain medications (e.g., Sotalol, quinidine, thioridazine, Chlorpromazine, droperidol, pimozide, gatifloxacin, moxifloxacin, Mefloquine, pentamidine, arsenic trioxide, probucol, Tacrolimus) can increase the risk of a type of abnormal heart rhythm called QT prolongation, and should not be used in combination with posaconazole. You are more at risk for this type of abnormal heart rhythm and its complications if you:

are female
are older than 65 years of age
have a family history of sudden cardiac death
have a history of heart disease or abnormal heart rhythms
have a slow heart rate
have congenital prolongation of the QT interval
have Diabetes
have had a Stroke
have low potassium, magnesium, or calcium levels
have nutritional deficiencies

If you have heart disease and abnormal heart rhythms, or people are taking certain medications (e.g., Verapamil, atazanavir), discuss with your doctor how Posanol may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Posanol, and whether any special monitoring is needed.

Allergy to other antifungals: If you are allergic to antifungals that are related to posaconazole (e.g., ketoconazole, fluconazole, itraconazole, or Voriconazole), your doctor will monitor you closely while you are taking Posanol. If you experience any symptoms of an allergic reaction such as a rash, contact your doctor immediately. If you experience symptoms of a serious allergic reaction (hives; difficulty breathing; swelling of the face, mouth, tongue, or throat), get immediate medical attention.

Blood problems: Rarely, serious blood problems (e.g., hemolytic uremic syndrome, thromobotic thrombocytopenic purpura) can occur while taking Posanol. If you experience vomiting, diarrhea, blood in the stools, weakness, paleness, bruising, confusion, fever, contact your doctor immediately. These rare but serious blood problems are more likely to occur when people are also taking Cyclosporine or tacrolimus to prevent transplant rejection.

Glucose: The oral suspension contains glucose. People with galactose or glucose-galactose malabsorption should check with their doctor before taking Posanol.

Liver problems: Decreased liver function or liver disease can cause Posanol to build up in the body, causing side effects. If you have liver problems, discuss with your doctor how Posanol may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Posanol, and whether any special monitoring is needed.

Posanol can also cause liver problems. Some people experience increases in liver function tests while taking posaconazole. These increases usually return to normal when posaconazole is stopped, and may return to normal without stopping treatment. Some people may experience symptoms of more severe liver problems (nausea, vomiting, abdominal pain, fatigue, yellowing of the skin or eyes, light coloured stools) while taking Posanol. If you experience any of these symptoms, contact your doctor immediately. Your doctor will monitor your liver function while you are taking posaconazole.

Pregnancy: Posanol should not be used during pregnancy unless the benefits outweigh the risks. Women who may become pregnant should use adequate contraception while taking Posanol. If you become pregnant while taking Posanol, contact your doctor immediately.

Breast-feeding: It is not known if posaconazole passes into breast milk. If you are a breast-feeding mother and are taking Posanol, it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.

Children: The safety and effectiveness of using Posanol have not been established for children under 13 years of age. The safety and effectiveness of the IV form of posaconazole has not been determined for people under 18 years of age.

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