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Persantine

Persantine

(dipyridamole)

Persantine (Dipyridamole) belongs to the class of medications called platelet aggregation inhibitors or antiplatelets. It is used to prevent Blood Clots that may occur after a heart valve replacement.

Available form

Dosage

Injectable

5MG/ML

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Persantine information

Dosage

Side Effects

Available Form

Contraindications

Precautions

Warnings

The recommended oral adult dose of Persantine (Dipyridamole) for preventing blood clots is 100 mg 4 times daily one hour before meals. If taken with 1000 mg of Asa daily, the dose of Persantine (Dipyridamole) can be reduced to 25 mg 4 times daily.

When used for medical tests that examine how well blood is flowing through the heart, Persantine (Dipyridamole) is given by injection in a hospital.

Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.

It is important to take Persantine (Dipyridamole) exactly as prescribed by your doctor. If you miss a dose, take it as soon as possible and continue with your regular schedule. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

Store Persantine (Dipyridamole) at room temperature, protect it from light and moisture, and keep it out of the reach of children.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.

The side effects listed below are not experienced by everyone who takes Persantine (Dipyridamole). If you are concerned about side effects, discuss the risks and benefits of this medication with your doctor.

The following side effects have been reported by at least 1% of people taking Persantine (Dipyridamole). Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

abdominal or stomach cramps
Diarrhea
dizziness or lightheadedness
flushing
headache
nausea or vomiting
weakness

Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

chest pain
gallstones
increased heart rate
Low Blood Pressure (symptoms may include dizziness or fainting)

signs of clotting problems (e.g., unusual nosebleeds, bruising, blood in urine, coughing blood, bleeding gums, cuts that don’t stop bleeding)
signs of liver problems (e.g., nausea, vomiting, diarrhea, loss of appetite, weight loss, yellowing of the skin or whites of the eyes, dark urine, pale stools)
skin rash

Stop taking the medication and seek immediate medical attention if any of the following occur:

chest pain
signs of bleeding in the stomach (e.g., bloody, black, or tarry stools, spitting up of blood, vomiting blood or material that looks like coffee grounds)
symptoms of a serious allergic reaction (such as Hives, difficulty breathing, or swelling of the face or throat)

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking Persantine (Dipyridamole).

There may be an interaction between Persantine (Dipyridamole) and any of the following:

acetylsalicylic acid (ASA)
Aliskiren
alpha blockers (e.g., Alfuzosin, Doxazosin, Tamsulosin)
alpha agonists (e.g., Clonidine, methyldopa)
Amiodarone
anti-cancer medications (e.g., Doxorubicin, Etoposide, Topotecan, Vinblastine)
Apixaban
beta-adrenergic blockers (e.g., Atenolol, Propranolol, Sotalol)
calcium channel blockers (e.g., Amlodipine, Diltiazem, Nifedipine, Verapamil)
Carvedilol
cetirizine
ciprofloxacin (systemic)
cholinesterase inhibitors (e.g., Donepezil, Galantamine, Rivastigmine)
Clopidogrel
Colchicine
Cyclosporine
dabigatran
Dexamethasone
Digoxin
erythromycin
estrogens (e.g., conjugated estrogen, Estradiol, ethinyl estradiol)
“gliptin” Diabetes medications (e.g., Linagliptin, Saxagliptin, Sitagliptin)
glucosamine
Heparin
herbal products that affect blood clotting (e.g., cat's claw, chamomile, fenugreek, evening primrose, feverfew, garlic, ginger, ginseng, turmeric)
HIV protease inhibitors (e.g., atazanavir, indinavir, ritonavir, saquinavir)
Hydrocortisone
Loperamide
low molecular weight heparins (e.g., Dalteparin, Enoxaparin, Tinzaparin)
Methotrexate
multivitamin supplements
non-steroidal anti-inflammatory medications (NSAIDs; e.g., Diclofenac, Ibuprofen, Naproxen)
Ondansetron
omega-3 fatty acids
Paliperidone
Pentoxifylline
protein kinase inhibitors (e.g., Crizotinib, Dasatinib, imatinib, Nilotinib)
Prucalopride
quinidine
quinine
Ranitidine
rifampin
Risperidone
Rivaroxaban
Romidepsin
selective serotonin reuptake inhibitors (SSRIs; e.g., Citalopram, Fluoxetine, Paroxetine, Sertraline)
serotonin-norepinephrine reuptake inhibitors (SNRIs; Desvenlafaxine, Duloxetine, Venlafaxine)
"statin" anti-cholesterol medications (e.g., Atorvastatin, Lovastatin, Simvastatin)
Tacrolimus
theophyllines (with injectable form of Persantine (Dipyridamole); Aminophylline, Theophylline)
Ticagrelor
Ticlopidine
Tolvaptan
vitamin E
Warfarin

If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

stop taking one of the medications,
change one of the medications to another,
change how you are taking one or both of the medications, or
leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with Persantine (Dipyridamole). Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the Nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.

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