Zolinza (Vorinostat) belongs to the class of medications called antineoplastics, or anticancer medications. It is used to treat a type of cancer called cutaneous T-cell lymphoma (CTCL) that gets worse, does not go away, or comes back after treatment with other medications.

CTCL is a type of cancer that affects certain cells of the lymph system and affects your skin. Zolinza (Vorinostat) works by reducing the activity of histone deacetylase (HDAC), and this slows or stops the growth of cancer cells or causes the death of cancer cells.

Your doctor may have suggested Zolinza (Vorinostat) for conditions other than those listed in these drug information articles. As well, some forms of Zolinza (Vorinostat) may not be used for all of the conditions discussed here. If you have not discussed this with your doctor or are not sure why you are taking Zolinza (Vorinostat), speak to your doctor. Do not stop taking Zolinza (Vorinostat) without consulting your doctor.

Do not give Zolinza (Vorinostat) to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take Zolinza (Vorinostat) if their doctor has not prescribed it.

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The recommended dose of Zolinza (Vorinostat) is 400 mg once daily with food. Your doctor may decrease your dose if you experience severe side effects. You should drink at least 2 litres of fluid a day while taking Zolinza (Vorinostat) to prevent dehydration. Swallow the capsules whole. Do not open or crush the capsules. Contact of the powder in the capsules with the skin or mucous membranes (e.g., mouth, nose) should be avoided. If contact does occur, wash the area thoroughly.

Many things can affect the dose of a medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.

It is important that Zolinza (Vorinostat) be taken exactly as prescribed by your doctor. If you miss a dose, take it as soon as possible and continue with your regular schedule. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

Store Zolinza (Vorinostat) at room temperature and keep it out of the reach of children.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent. The side effects listed below are not experienced by everyone who takes Zolinza (Vorinostat). If you are concerned about side effects, discuss the risks and benefits of Zolinza (Vorinostat) with your doctor.

The following side effects have been reported by at least 1% of people taking Zolinza (Vorinostat). Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

• abdominal pain
• chills
• Constipation
• decreased or loss of appetite
• Diarrhea
• dizziness
• Dry Mouth
• fatigue
• hair loss
• headache
• muscle spasms
• nausea
• taste disturbance
• vomiting
• weight loss

Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

• fainting
• symptoms of Anemia (e.g., feeling tired, shortness of breath, paleness, fast heart rate)
• symptoms of dehydration (e.g., thirst, reduced sweating, decreased urine production, dry mouth)
• symptoms of low platelet counts (e.g., easy bruising or unusual bleeding)

Stop taking the medication and seek immediate medical attention if any of the following occur:

• fainting
• symptoms of a blood clot in the leg or arm (e.g., pain, redness, warmth, swelling)
• symptoms of a blood clot in the lungs (e.g., shortness of breath, chest pain)
• symptoms of a Stroke (e.g., sudden numbness or weakness in the arms or legs, dizziness, severe headache, difficulty speaking, vision changes)
• symptoms of an infection in the blood (e.g., Fever, chills, headache, confusion, rapid breathing)
• symptoms of bleeding in the stomach or intestines (e.g., black and tarry stools, vomit that look like coffee grounds, stomach pain)

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking Zolinza (Vorinostat).

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We manage your refills and get in touch with your doctors for prescription renewals so that you always have the medication you need.

Each white, opaque, hard gelatin capsule with "568" over "100 mg" printed within radial bar in black ink on the capsule body, contains Zolinza (Vorinostat) 100 mg. Nonmedicinal ingredients: magnesium stearate, microcrystalline cellulose, and sodium croscarmellose; capsule shell: gelatin, titanium dioxide, and may contain sodium lauryl sulfate.

Zolinza (Vorinostat) should not be taken by anyone who:

• is allergic to Zolinza (Vorinostat) or to any of the ingredients of the medication
• has severely reduced liver function

Discreet Packaging

Your privacy is important. That's why we send your medication inside a plain delivery box so no one will know what's inside.

There may be an interaction between Zolinza (Vorinostat) and any of the following:

If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

• stop taking one of the medications,
• change one of the medications to another,
• change how you are taking one or both of the medications, or
• leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with Zolinza (Vorinostat). Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the Nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.

Before you begin using a medication, be sure to inform your doctor of any medical conditions or Allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use Zolinza (Vorinostat).

Blood Clots: Zolinza (Vorinostat) can increase your risk of getting a blood clot in the legs, arms, or lungs. People who have had a blood clot in the past should discuss with their doctor how Zolinza (Vorinostat) may affect their medical condition, how their medical condition may affect the dosing and effectiveness of Zolinza (Vorinostat), and whether any special monitoring is needed. If you experience symptoms of a blood clot in the leg or arm (pain, redness, warmth, swelling), or in the lungs (chest pain, shortness of breath), get immediate medical attention.

Blood effects: Zolinza (Vorinostat) can decrease platelets (help with blood clotting) and reduce red blood cells. Your doctor will monitor for these with blood tests. If you experience unusual bleeding or bruising, shortness of breath, tiredness, or paleness while taking Zolinza (Vorinostat), contact your doctor immediately.

Blood sugar: Zolinza (Vorinostat) can cause high blood sugar levels (hyperglycemia). Your doctor will monitor your blood sugar levels closely while you are receiving Zolinza (Vorinostat). People with Diabetes should report any changes in their blood sugar control to their doctor immediately. Your doctor may suggest dietary and medication changes or may reduce your dose of Zolinza (Vorinostat) to help keep your blood sugar levels controlled.

Dehydration: Zolinza (Vorinostat) can cause dehydration (too much water loss from your body). In order to prevent this, you should drink at least 2 litres of fluids a day while you are taking Zolinza (Vorinostat). If you experience severe nausea, vomiting, and diarrhea while taking Zolinza (Vorinostat), contact your doctor. These side effects can lead to dehydration.

Dizziness and fainting: Zolinza (Vorinostat) can cause dizziness or fainting. Do not drive or operate machinery if you experience these side effects and until you know you can perform these activities safely.

Heart effects: Zolinza (Vorinostat) can have an effect on the electrical activity of the heart called QT prolongation. This can lead to a serious abnormal heart rhythm, which can be fatal. People who are at an increased risk of experiencing abnormal heart rhythms (e.g., women, people 65 years of age and older, people with heart disease, a family history of sudden death, abnormal heart rhythms, congenital long QT syndromes, strokes, Eating Disorders, diabetes, low blood levels of potassium, magnesium, or calcium) should discuss with their doctor how Zolinza (Vorinostat) may affect their medical condition, how their medical condition may affect the dosing and effectiveness of Zolinza (Vorinostat), and whether any special monitoring is needed. Your doctor may check your heart rhythm with an ECG (electrocardiogram) to check for the effects of Zolinza (Vorinostat) on your heart.

If you experience symptoms of an abnormal heart rhythm (e.g., dizziness, fainting seizures, pounding or irregular heartbeat) while taking Zolinza (Vorinostat), get immediate medical attention.

Heart rate: Zolinza (Vorinostat) can increase your heart rate. People with heart disease or fast heartbeats should discuss with their doctor how Zolinza (Vorinostat) may affect their medical condition, how their medical condition may affect the dosing and effectiveness of Zolinza (Vorinostat), and whether any special monitoring is needed.

Kidney: People with reduced kidney function should discuss with their doctor how Zolinza (Vorinostat) may affect their medical condition, how their medical condition may affect the dosing and effectiveness of Zolinza (Vorinostat), and whether any special monitoring is needed.

Liver problems: People with liver problems should discuss with their doctor how Zolinza (Vorinostat) may affect their medical condition, how their medical condition may affect the dosing and effectiveness of Zolinza (Vorinostat), and whether any special monitoring is needed. People with severely reduced liver function should not take Zolinza (Vorinostat).

Pregnancy: Women taking Zolinza (Vorinostat) should avoid becoming pregnant. Zolinza (Vorinostat) should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking Zolinza (Vorinostat), contact your doctor immediately.

Breast-feeding: It is not known if Zolinza (Vorinostat) passes into breast milk. Women taking Zolinza (Vorinostat) should not breast-feed.

Children: The safety and effectiveness of using Zolinza (Vorinostat) have not been established for children.

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