Before you begin using a medication, be sure to inform your doctor of any medical conditions or Allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use Odomzo (Sonidegib).
Birth control: Odomzo (Sonidegib) appears in the sperm of men taking Odomzo (Sonidegib). To protect your partner, as well as prevent pregnancy, all men who are taking Odomzo (Sonidegib) and have a partner who could become pregnant must use a condom while taking the medication and for 6 months after the last dose.
Women who are taking Odomzo (Sonidegib) must use 2 reliable forms of birth control, beginning at least 4 weeks before starting Odomzo (Sonidegib), while taking Odomzo (Sonidegib), and for 20 months after the last dose. At least one of these methods must be a highly effective method of birth control and one must be a barrier method, such as condom or diaphragm with spermicide.
Your doctor will have you do a pregnancy test monthly starting the week before the first dose of the medication, while you are taking Odomzo (Sonidegib), and for 20 months after the last dose.
Blood donation: Avoid donating blood for at least 20 months after taking the last dose of Odomzo (Sonidegib).
Liver function:Â Liver disease or reduced liver function may cause Odomzo (Sonidegib) to build up in the body, causing side effects. If you have liver problems, discuss with your doctor how Odomzo (Sonidegib) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Odomzo (Sonidegib), and whether any special monitoring is needed.
Muscle effects: Muscle damage has been associated with the use of Odomzo (Sonidegib). Report any unexplained muscle pain, tenderness, weakness, or cramps, or any brown or discoloured urine to your doctor immediately, particularly if you are also experiencing malaise (a general feeling of being unwell) or Fever.
Other cancers: There have been reports of squamous cell carcinoma, another form of skin cancer, developing after taking Odomzo (Sonidegib). This type of skin cancer may appear as scaly red patches; open sores; or rough, thickened, or wart-like skin. It may also appear as raised growths on the skin. Report any changes to your skin to your doctor as soon as possible.
Pregnancy: Odomzo (Sonidegib) can cause severe birth defects affecting the baby if the mother takes Odomzo (Sonidegib) during pregnancy. Two forms of effective birth control must be used while taking Odomzo (Sonidegib) and for 20 months after the last dose. If you become pregnant while taking Odomzo (Sonidegib), contact your doctor immediately.
Breast-feeding: It is not known if Odomzo (Sonidegib) passes into breast milk. If you are breast-feeding and are taking Odomzo (Sonidegib), it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.
Children: The safety and effectiveness of using Odomzo (Sonidegib) have not been established for children.
Seniors: It is likely that people over the age of 65 will experience more side effects and more severe side effects.
