Before you begin using a medication, be sure to inform your doctor of any medical conditions or Allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use Daurismo (Glasdegib).
Anemia: Daurismo (Glasdegib) may cause low levels of red blood cells. If you experience symptoms of reduced red blood cell count (anemia) such as shortness of breath, feeling unusually tired, or pale skin, contact your doctor as soon as possible.
Your doctor will do blood tests regularly to monitor the number of specific types of blood cells, including red blood cells, in your blood.
Birth control: If you are male and have a partner who is or may become pregnant, it is important that you use effective birth control, including a condom, even if you have had a vasectomy. This should be continued while taking Daurismo (Glasdegib) and for 30 days after the last dose of medication.
Women who may become pregnant should use 2 methods of effective birth control while taking Daurismo (Glasdegib) and for 30 days after the last dose of Daurismo (Glasdegib).
Clotting problems: Daurismo (Glasdegib) may cause a reduced number of platelets in the blood, which can make it difficult to stop cuts from bleeding. If you notice any signs of bleeding, such as frequent nosebleeds, unexplained bruising, or black and tarry stools, notify your doctor as soon as possible. Your doctor will order routine blood tests to make sure potential problems are caught early.
Drowsiness/reduced alertness: Daurismo (Glasdegib) may cause fatigue, affecting your ability to drive or operate machinery. Avoid driving, operating machinery, or performing other potentially hazardous tasks until you have determined how you Daurismo (Glasdegib) affects you.
Heart rhythm: Daurismo (Glasdegib) can cause changes to the normal rhythm of the heart, including an irregular heartbeat called QT prolongation. QT prolongation is a serious life-threatening condition that can cause fainting, seizures, and sudden death. If you are at risk for heart rhythm problems (e.g., people with heart failure, Angina, low potassium or magnesium levels), discuss with your doctor how Daurismo (Glasdegib) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Daurismo (Glasdegib), and whether any special monitoring is needed.
Your doctor will monitor your heart rhythm regularly while you are taking Daurismo (Glasdegib) with a test called an electrocardiogram (ECG). You should not take Daurismo (Glasdegib) if your ECG already shows that you have QT prolongation or if you are taking a medication that can cause QT prolongation.
Infection: As well as killing cancer cells, Daurismo (Glasdegib) can reduce the number of cells that fight infection in the body (white blood cells). If possible, avoid contact with people with contagious infections. Tell your doctor immediately if you notice signs of an infection, such as fever or chills, severe diarrhea, shortness of breath, prolonged dizziness, headache, stiff neck, weight loss, or listlessness. Your doctor will do blood tests regularly to monitor the number of specific types of blood cells in your blood.
Liver function: If you have liver problems, discuss with your doctor how Daurismo (Glasdegib) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Daurismo (Glasdegib), and whether any special monitoring is needed. Your doctor may want to test your liver function regularly with blood tests while you are taking Daurismo (Glasdegib).
Pregnancy: Daurismo (Glasdegib) should not be used during pregnancy, as it may cause harm to the developing baby. If you become pregnant while taking Daurismo (Glasdegib), contact your doctor immediately.
Breast-feeding: It is not known if Daurismo (Glasdegib) passes into breast milk. Breast-feeding is not recommended while taking Daurismo (Glasdegib).
Children: The safety and effectiveness of using Daurismo (Glasdegib) have not been established for children.
