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Epclusa

Epclusa

Sofosbuvir - velpatasvir is used alone or with ribavirin to treat chronic (long-term) Hepatitis C virus (HCV) infection. This combination product contains 2 medications: sofosbuvir and velpatasvir.

Available form

Dosage

Tablet

400+100MG

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Epclusa information

Dosage

Side Effects

Available Form

Contraindications

Precautions

Warnings

The recommended dose of Epclusa for adults and children aged 12 years and older who weigh 30 kg or more is 1 tablet taken by mouth, once daily. It is generally taken for 12 weeks.

Sofosbuvir - velpatasvir can be taken with food or on an empty stomach.

If you vomit within 3 hours of taking the medication, take another dose of the medication. If it is longer than 3 hours since you have taken the medication, do not take another tablet. Continue with your normal dose schedule.

Finish all Epclusa, even if you have started to feel better.

Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.

It is important to take Epclusa exactly as prescribed by your doctor. If you miss a dose, and it is within 18 hours of the missed dose, take it as soon as possible and continue with your regular schedule. If it is more than 18 hours since the missed dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

Store Epclusa in the original packaging, at room temperature, protect it from light and moisture, and keep it out of the reach of children.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

There may be an interaction between sofosbuvir - velpatasvir and any of the following:

Aliskiren
Amiodarone
antacids (e.g., aluminum hydroxide, calcium carbonate, magnesium hydroxide)
anticancer medications (e.g., Doxorubicin, Etoposide, Paclitaxel, Vincristine)
Apalutamide
bilastine
Bosentan
Colchicine
Cyclosporine
dabigatran
Deferasirox
Diabetes medications (e.g., Canagliflozin, Glyburide, insulin, Linagliptin, Liraglutide, Metformin, Rosiglitazone)
Digoxin
Edoxaban
Elagolix
Eliglustat
Enzalutamide
Everolimus
H2 antagonists (e.g., Famotidine, Ranitidine)
hepatitis C antivirals (e.g., glecaprevir and pibrentasvir, grazoprevir, ledipasvir, voxilaprevir)
HIV non-nucleoside reverse transcriptase inhibitors (NNRTIs; e.g., efavirenz, etravirine, nevirapine)
HIV protease inhibitors (e.g., ritonavir, tipranavir)
lumacaftor and Ivacaftor
Modafinil
Morphine
Nadolol
Naloxegol
proton pump inhibitors (e.g., Lansoprazole, Omeprazole)
rifabutin
rifampin
rifaximin
Risperidone
Romidepsin
Sarilumab
seizure medications (e.g., Carbamazepine, Clobazam, Levetiracetam, Phenobarbital, Phenytoin, primidone, Topiramate, Valproic acid, zonisamide)
St. John's wort
Silodosin
siltuximab
Sirolimus
"statin" anti-cholesterol medications (e.g., Atorvastatin, Lovastatin, Rosuvastatin, Simvastatin)
Tacrolimus
Tocilizumab
Tolvaptan
tyrosine kinase inhibitors (e.g., Bosutinib, Crizotinib, Dabrafenib, imatinib, Lapatinib, Nilotinib)
Warfarin

If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

stop taking one of the medications,
change one of the medications to another,
change how you are taking one or both of the medications, or
leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with Epclusa. Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the Nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.

Before you begin using a medication, be sure to inform your doctor of any medical conditions or Allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use Epclusa.

Hepatitis B co-infection: Talk to your doctor before taking Epclusa if you have or have had hepatitis B. People with hepatitis B infection that is dormant may experience a recurrence of the hepatitis B while they are taking sofosbuvir – velpatasvir or after they stop taking Epclusa. This can result in severe liver damage and possibly life-threatening liver failure. If you experience symptoms of worsening liver function, such as fatigue, feeling unwell, loss of appetite, nausea, yellowing of the skin or whites of the eyes, dark urine, pale stools, abdominal pain or swelling, and itchy skin, contact your doctor immediately.

Human immunodeficiency virus (HIV) co-infection: Sofosbuvir - velpatasvir has been found to be a safe and effective treatment for hepatitis C, for people who also have HIV infection. Some of the medications used to treat HIV infection may affect sofosbuvir or velpatasvir and change how these medications work in the body. If you have HIV infection, discuss with your doctor how Epclusa may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Epclusa, and whether any special monitoring is needed.

Liver transplant: The safety and effectiveness of using sofosbuvir - velpatasvir after having a liver transplant have not been determined. Epclusa is not recommended for anyone who has had a liver transplant.

Pregnancy and contraception: The use of Epclusa is not recommended for pregnant women or women who may become pregnant, as it is not known if sofosbuvir - velpatasvir will harm an unborn child. If you become pregnant while taking Epclusa, contact your doctor immediately.

If you are using ribavirin along with sofosbuvir - velpatasvir, you must use 2 forms of effective birth control (one for each partner) during treatment and for 6 months after stopping the medication. During this time, women will have monthly pregnancy tests to ensure they are not pregnant. Tell your doctor immediately if you become pregnant while using Epclusa.

Breast-feeding: It is not known if sofosbuvir or velpatasvir pass into breast milk. If you are breast-feeding and are taking Epclusa, it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.

Children: The safety and effectiveness of using Epclusa have not been established for children less than 12 years of age or who weigh less than 30kg. Epclusa has not been studied for children with moderate or severe liver impairment.

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