Available in:Injectable Pen
Dosage:18MG/3ML
Manufacturer:Novo Nordisk
Available in:12-Hour Release Tablet
Dosage:5+2.5MG, 10+5MG, 8+90MG, 20+10MG, 40+20MG, 5+120MG, 60+120MG
Manufacturer:Bausch Health
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The recommended starting dose of Saxenda (Liraglutide) is 0.6 mg daily injected subcutaneously (under the skin) on your stomach area (abdomen), upper thigh, or upper arm, exactly as instructed by your doctor. It can be injected at any time of the day, without regard to meals. After one week, your doctor will increase the dose to 1.2 mg once daily, gradually increasing the dose to the recommended 3 mg daily. This gradual increase of the dose should minimize side effects on the digestive system. Adolescents should follow the same gradual increase in dose. If 3 mg daily produces unacceptable side effects, the dose may be reduced to 2.4 mg daily.
Your doctor or nurse will assist you in the preparation and injection of your first dose (or first few doses) and can teach you how to give yourself the injection at home. Do not attempt to inject Saxenda (Liraglutide) on your own until you completely understand how to inject a dose. If you are unsure of how to prepare or administer a dose, ask a health care professional to clarify for you. If you are having difficulty giving yourself injections, ask a family member or other caregiver for help if they are willing to become involved with your treatment and are willing to learn how to give you your injections.
Use a different injection site for each dose. Avoid injecting Saxenda (Liraglutide) into an area of skin that is sore, red, infected, or otherwise damaged.
Saxenda (Liraglutide) should be clear and colourless. Do not use Saxenda (Liraglutide) if you notice particles or anything unusual in the appearance of the solution.
Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.
It is important to take Saxenda (Liraglutide) exactly as prescribed by your doctor. If you miss a dose, skip the missed dose and continue with your regular dosing schedule. If you miss more than 3 doses in a row, contact your doctor or pharmacist for instructions. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.
Store Saxenda (Liraglutide) in the refrigerator, do not allow it to freeze, and keep it out of the reach of children. After the first use of the pen, Saxenda (Liraglutide) can be stored at room temperature or in the refrigerator for up to 30 days. To protect Saxenda (Liraglutide) from light, always keep the pen cap on when you are not using it. Always store Saxenda (Liraglutide) without a needle attached to prevent contamination, infection, and leakage.
Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.
The usual starting dose of Contrave is one tablet taken by mouth once daily, in the morning for the first week. For the second week, the dose is one tablet twice a day, once in the morning and one with the evening meal. The dose is increased by 1 tablet daily each week until the recommended maximum daily dose of two tablets taken twice daily.
Naltrexone-bupropion may be taken with meals. High-fat meals should be avoided, as this increases the amount of medication in the body and can increase the side effects. Swallow the tablets whole and do not cut, crush, or chew them.
Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.
It is important to take Contrave exactly as prescribed by your doctor.
If you miss a dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.
Store Contrave at room temperature, protect it from light and moisture, and keep it out of the reach of children.
Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.
Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.
The side effects listed below are not experienced by everyone who takes Saxenda (Liraglutide). If you are concerned about side effects, discuss the risks and benefits of Saxenda (Liraglutide) with your doctor.
The following side effects have been reported by at least 1% of people taking Saxenda (Liraglutide). Many of these side effects can be managed, and some may go away on their own over time.
Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.
Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not seek medical attention.
Check with your doctor as soon as possible if any of the following side effects occur:
Stop taking the medication and seek immediate medical attention if any of the following occur:
Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking Saxenda (Liraglutide).
Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.
The side effects listed below are not experienced by everyone who takes Contrave. If you are concerned about side effects, discuss the risks and benefits of Contrave with your doctor.
The following side effects have been reported by at least 1% of people taking Contrave. Many of these side effects can be managed, and some may go away on their own over time.
Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.
Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not seek medical attention.
Check with your doctor as soon as possible if any of the following side effects occur:
Stop taking the medication and seek immediate medical attention if any of the following occur:
Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking Contrave.
Each mL of clear, colourless solution contains 6 mg of Saxenda (Liraglutide). Nonmedicinal ingredients: disodium phosphate dihydrate, propylene glycol, phenol, and water for injection.
Each round, biconvex, blue, film-coated, extended-release tablet, debossed with NB-890 on one side, contains 8 mg of naltrexone hydrochloride and 90 mg of bupropion hydrochloride. Nonmedicinal ingredients: colloidal silicon dioxide, crospovidone, edetate disodium, FD&C Blue No. 2 indigo carmine aluminum lake, hydroxypropyl cellulose, ypromellose, lactose anhydrous, lactose monohydrate, L-cysteine hydrochloride, macrogol/peg, magnesium stearate, microcrystalline cellulose, polyvinyl alcohol-part hydrolyzed, talc, and titanium dioxide.
Do not take Saxenda (Liraglutide) if you:
Do not take Contrave if you:
There may be an interaction between Saxenda (Liraglutide) and any of the following:
If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:
An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.
Medications other than those listed above may interact with Saxenda (Liraglutide). Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the Nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.
There may be an interaction between naltrexone – bupropion and any of the following:
If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:
An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.
Medications other than those listed above may interact with Contrave. Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.
Before you begin using a medication, be sure to inform your doctor of any medical conditions or Allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use Saxenda (Liraglutide).
Breast Cancer: There may be an increased risk of developing breast cancer when using Saxenda (Liraglutide). Talk to your doctor if you have any concerns.
Gallstones: Saxenda (Liraglutide) has been associated with an increase in gallstone formation. Gallstones often form when there is significant or fast weight loss. If you experience symptoms of gallstones, such as nausea and vomiting, pain under the right shoulder or between the shoulder blades or severe abdominal pain, contact your doctor as soon as possible.
Heart problems: Saxenda (Liraglutide) may increase heart rate and may affect how electrical impulses travel through the heart muscle. If you have heart disease (e.g., recent Heart Attack, Angina, heart failure) or an abnormal heart rhythm (e.g., heart block or fast heart rate), discuss with your doctor how Saxenda (Liraglutide) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Saxenda (Liraglutide), and whether any special monitoring is needed.
Intestinal problems: The safety and effectiveness of using Saxenda (Liraglutide) for people with inflammatory bowel disease (e.g., Crohn's Disease, Ulcerative Colitis) or who have slowed movement through the intestinal tract due to diabetes have not been established. If you have digestive system problems, discuss with your doctor how Saxenda (Liraglutide) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Saxenda (Liraglutide), and whether any special monitoring is needed.
Kidney function: Saxenda (Liraglutide) can cause dehydration as a result of digestive system side effects such as diarrhea, which in turn, can affect kidney function. Make sure you drink enough fluids to prevent dehydration. The safety and effectiveness of using Saxenda (Liraglutide) for people with reduced kidney function has not been studied. If you have reduced kidney function or Kidney Disease, discuss with your doctor how Saxenda (Liraglutide) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Saxenda (Liraglutide), and whether any special monitoring is needed.
Liver function: The safety and effectiveness of using Saxenda (Liraglutide) for people with reduced liver function have not been studied. If you have reduced liver function or liver disease, discuss with your doctor how Saxenda (Liraglutide) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Saxenda (Liraglutide), and whether any special monitoring is needed.
Low blood glucose (hypoglycemia): People who use Saxenda (Liraglutide) may experience low blood sugar. This may be more likely if you are also taking a sulfonylurea (e.g., Glyburide, Gliclazide) to control high blood sugar. If you experience symptoms of hypoglycemia such as a cold sweat, nervousness or shakiness, fast heartbeat, headache, hunger, confusion, lightheadedness, weakness, and numbness or tingling of the tongue or lips, contact your doctor.
Pancreatitis (inflammation of the pancreas): Saxenda (Liraglutide) can cause pancreatitis. If you experience symptoms of pancreatitis such as severe and persistent abdominal pain that may move to the back with or without vomiting, contact your doctor immediately. If you have previously had pancreatitis, discuss with your doctor how Saxenda (Liraglutide) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Saxenda (Liraglutide), and whether any special monitoring is needed.
Thyroid cancer: In rare cases, people have developed thyroid cancer while using Saxenda (Liraglutide). People with a personal or family history of thyroid cancer or people who have multiple endocrine neoplasia syndrome type 2 (a disease where people have tumours in more than one gland in their body) should not use Saxenda (Liraglutide).
Suicidal or depressed behaviour: People using Saxenda (Liraglutide) may experience new or worsening symptoms of Depression, thoughts of self-harm, or change in mood and behavior. If you experience these side effects or notice them in a family member who is taking Saxenda (Liraglutide), contact your doctor immediately.
Pregnancy: Saxenda (Liraglutide) has not been studied for use by pregnant women and should not be used during pregnancy. If you become pregnant while using Saxenda (Liraglutide), contact your doctor immediately.
Breast-feeding: It is not known if Saxenda (Liraglutide) passes into breast milk. If you are breast-feeding and are taking Saxenda (Liraglutide), it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.
Children: Saxenda (Liraglutide) may be used for children and adolescents between the ages of 12 and 18 years, who weigh at least 60 kg. The safety and effectiveness of using Saxenda (Liraglutide) have not been established for children younger than 12 years of age.
Seniors: Seniors may be more likely to experience side effects associated with Saxenda (Liraglutide).
Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use Contrave.
Accidental ingestion: If you are dependent on narcotics and you ingest Contrave, you could experience severe symptoms of withdrawal including confusion, nausea, shakiness, sweating, anxiety, visual hallucinations, vomiting, or diarrhea. Avoid taking narcotic medications while you are taking naltrexone-bupropion.
Diabetes: Weight loss often causes decreased blood glucose. As a result, using naltrexone-bupropion may cause episodes of low blood sugar when taken by people with diabetes who are taking certain oral medications to control blood sugar. You may find it necessary to monitor your blood sugar more frequently while using Contrave.
If you have diabetes or are at risk for developing diabetes, discuss with your doctor how Contrave may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Contrave, and whether any special monitoring is needed.
Drowsiness/reduced alertness: Bupropion may affect the mental or physical abilities needed to drive or operate machinery. Avoid driving, operating machinery, or performing other hazardous tasks until you have determined how Contrave affects you.
Heart disease: Bupropion can increase blood pressure and heart rate. It is not known whether it is safe for use by people with a recent history of Heart Attack or unstable heart disease. If you have had a heart attack within the past 6 months, have an irregular heartbeat, high blood pressure, Congestive Heart Failure or a recent Stroke, discuss with your doctor how Contrave may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Contrave, and whether any special monitoring is needed.
Galactose intolerance/glucose malabsorption: Contrave contains lactose. If you have lactose or galactose intolerance you should not take Contrave.
Glaucoma: Contrave may cause the symptoms of glaucoma (increased pressure in the eye) to become worse. If you have glaucoma, discuss with your doctor how Contrave may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Contrave, and whether any special monitoring is needed. Report any changes in vision to your doctor as soon as possible while you are taking Contrave.
Identical medications: Wellbutrin®, Zyban® and several other medications contain bupropion. Revia® and Relistor® contain naltrexone. If you are taking naltrexone-bupropion, do not take any other product containing bupropion or naltrexone, as the risk of side effects increases with an increased dosage.
Interference with opiate-containing mediations: Because Contrave works by blocking the effects of opiates, it will reduce the effectiveness of narcotic pain relievers. It may also interfere with other medications that contain opiates such as certain cough and cold medications, antidiarrheal medications, and some analgesics (pain medications). Trying to overcome the blocking effects of naltrexone by taking larger doses of narcotics may result in severe side effects of the narcotic. Talk to your doctor or pharmacist about non-opiate containing alternatives.
Kidney function: Kidney Disease or reduced kidney function may cause Contrave to build up in the body, causing side effects. If you have kidney problems, discuss with your doctor how Contrave may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Contrave, and whether any special monitoring is needed. Contrave is not recommended for people with end-stage kidney disease.
Liver function: Liver disease or reduced liver function may cause Contrave to build up in the body, causing side effects. If you have liver problems, discuss with your doctor how Contrave may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Contrave, and whether any special monitoring is needed. Naltrexone-bupropion is not recommended for people with severely decreased liver function.
Naltrexone-bupropion has been reported to cause decreased liver function. If you experience symptoms of liver problems such as fatigue, feeling unwell, loss of appetite, nausea, yellowing of the skin or whites of the eyes, dark urine, pale stools, abdominal pain or swelling, and itchy skin, contact your doctor immediately.
Lupus: There may be an association between taking naltrexone – bupropion and the autoimmune conditions systemic lupus erythematosus (SLE) and cutaneous lupus erythematosus (CLE). If you develop any skin rash (particularly on the face), fatigue, joint pain, or swelling, contact your doctor as soon as possible.
Mental health: Bupropion may trigger mania and make behaviour and thought disturbances worse for people who have mental health conditions. It may also cause symptoms of psychosis and mania to develop for people who have not had these symptoms before. If you experience symptoms such as hallucinations, mania (feeling unusually over-excited or uninhibited), or delusional thinking, or notice them in a family member who is taking Contrave, contact your doctor as soon as possible. If you have mental health concerns, discuss with your doctor how Contrave may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Contrave, and whether any special monitoring is needed.
Seizure risk: Bupropion may increase the risk of seizures. If you are at risk of seizures, discuss with your doctor how Contrave may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Contrave, and whether any special monitoring is needed.
Things that increase the risk of seizures include:
Serotonin toxicity: Severe reactions are possible when naltrexone - bupropion is combined with other medications that act on serotonin, such as tricyclic antidepressants and serotonin reuptake inhibitors, medications used to treat depression. Symptoms of a reaction may include muscle rigidity and spasms, difficulty moving, and changes in mental state including delirium and agitation. Coma and death are possible.
Suicidal or agitated behaviour, or other behaviour changes: People taking Contrave may feel agitated (restless, anxious, aggressive, emotional, and feeling not like themselves), or they may want to hurt themselves or others. These symptoms may occur within several weeks after people start taking Contrave. If you experience these side effects or notice them in a family member who is taking Contrave, contact your doctor immediately. Your doctor will monitor you for emotional and behavioural changes while you are taking bupropion.
Pregnancy: Weight loss does not benefit a woman during pregnancy and may cause harm to the developing baby. Use of either of these medications may also cause harm to the developing baby. For these reasons, Contrave should not be used during pregnancy. If you become pregnant while taking Contrave, contact your doctor immediately.
Breast-feeding: Both naltrexone and bupropion pass into breast milk. If you are breast-feeding and are taking Contrave, it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.
Children: The safety and effectiveness of using Contrave have not been established for children.
Seniors: Seniors may be at an increased risk of side effects due to age-related decreased kidney or liver function.
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