Available in:Tablet
Dosage:25MG, 50MG, 100MG
Manufacturer:Merck
Available in:Tablet
Dosage:2.5MG, 5MG
Manufacturer:Astrazeneca
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The usual dose of Januvia (Sitagliptin) is 100 mg taken by mouth once daily with or without food.
Many things can affect the dose of a medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.
It is important to take Januvia (Sitagliptin) exactly as prescribed by your doctor. If you miss a dose, take it as soon as possible and continue with your regular schedule. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.
Store Januvia (Sitagliptin) at room temperature and keep it out of the reach of children.
Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.
The usual dose of Onglyza (Saxagliptin) is 5 mg taken by mouth once daily with or without food. Swallow the tablet whole with some fluid. Do not split the tablet.
Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.
It is important to take Onglyza (Saxagliptin) exactly as prescribed by your doctor. If you miss a dose, take it as soon as possible and continue with your regular schedule. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.
Store Onglyza (Saxagliptin) at room temperature and keep it out of the reach of children.
Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.
Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.
The side effects listed below are not experienced by everyone who takes Januvia (Sitagliptin). If you are concerned about side effects, discuss the risks and benefits of Januvia (Sitagliptin) with your doctor.
The following side effects have been reported by at least 1% of people taking Januvia (Sitagliptin). Many of these side effects can be managed, and some may go away on their own over time.
Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.
Although most of these side effects listed below don't happen very often, they could lead to serious problems if you do not seek medical attention.
Check with your doctor as soon as possible if any of the following side effects occur:
Stop taking the medication and seek immediate medical attention if any of the following occur:
Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking Januvia (Sitagliptin).
Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.
The side effects listed below are not experienced by everyone who takes Onglyza (Saxagliptin). If you are concerned about side effects, discuss the risks and benefits of Onglyza (Saxagliptin) with your doctor.
The following side effects have been reported by at least 1% of people taking Onglyza (Saxagliptin). Many of these side effects can be managed, and some may go away on their own over time.
Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.
Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not seek medical attention.
Check with your doctor as soon as possible if any of the following side effects occur:
Stop taking the medication and seek immediate medical attention if any of the following occur:
Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking Onglyza (Saxagliptin).
25 mg
Each pink, round, film-coated tablet, with "221" on one side, contains 25 mg of Januvia (Sitagliptin). Nonmedicinal ingredients: microcrystalline cellulose, anhydrous dibasic calcium phosphate (calcium hydrogen phosphate, anhydrous), croscarmellose sodium, magnesium stearate, and sodium stearyl fumarate; film coating: polyvinyl alcohol, polyethylene glycol (macrogol), talc, titanium dioxide, red iron oxide, and yellow iron oxide.
50 mg
Each light beige, round, film-coated tablet, with "112" on one side, contains 50 mg of Januvia (Sitagliptin). Nonmedicinal ingredients: microcrystalline cellulose, anhydrous dibasic calcium phosphate (calcium hydrogen phosphate, anhydrous), croscarmellose sodium, magnesium stearate, and sodium stearyl fumarate; film coating: polyvinyl alcohol, polyethylene glycol (macrogol), talc, titanium dioxide, red iron oxide, and yellow iron oxide.
100 mg
Each beige, round, film-coated tablet, with "277" on one side, contains 100 mg of Januvia (Sitagliptin). Nonmedicinal ingredients: microcrystalline cellulose, anhydrous dibasic calcium phosphate (calcium hydrogen phosphate, anhydrous), croscarmellose sodium, magnesium stearate, and sodium stearyl fumarate; film coating: polyvinyl alcohol, polyethylene glycol (macrogol), talc, titanium dioxide, red iron oxide, and yellow iron oxide.
2.5 mg
Each pale yellow, biconvex, round, film-coated tablet, with "2.5" printed on one side and "4214" printed on the other side in blue ink, contains 2.5 mg of Onglyza (Saxagliptin) as Onglyza (Saxagliptin) hydrochloride. Nonmedicinal ingredients: croscarmellose sodium, lactose monohydrate, magnesium stearate, and microcrystalline cellulose; film coating: yellow iron oxide, polyethylene glycol, polyvinyl alcohol, talc, and titanium dioxide; printing ink: FD&C Blue No. 2 and shellac glaze.
5 mg
Each pink, biconvex, round, film-coated tablet with "5" printed on one side and "4215" printed on the other side in blue ink, contains 5 mg of Onglyza (Saxagliptin) as Onglyza (Saxagliptin) hydrochloride. Nonmedicinal ingredients: croscarmellose sodium, lactose monohydrate, magnesium stearate, and microcrystalline cellulose; film coating: red iron oxide, polyethylene glycol, polyvinyl alcohol, talc, and titanium dioxide; printing ink: FD&C Blue No. 2 and shellac glaze.
Januvia (Sitagliptin) should not be taken by anyone who is allergic to Januvia (Sitagliptin) or to any of the ingredients of the medication.
Do not take Onglyza (Saxagliptin) if you:
There may be an interaction between Januvia (Sitagliptin) and any of the following:
If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:
An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.
Medications other than those listed above may interact with Januvia (Sitagliptin). Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.
There may be an interaction between Onglyza (Saxagliptin) and any of the following:
If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:
An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.
Medications other than those listed above may interact with Onglyza (Saxagliptin). Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the Nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.
Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use Januvia (Sitagliptin).
Hypersensitivity reaction: A Anaphylaxis (severe allergic reaction) called hypersensitivity reaction has occurred for some people with the use of Januvia (Sitagliptin). Stop taking the medication and get immediate medical attention if you have symptoms of a severe allergic reaction, including Fever, swollen glands, yellowing of the skin or eyes, or flu-like symptoms with skin rash or blistering.
Immune system: Januvia (Sitagliptin) can reduce the number of cells that fight infection in the body (white blood cells). This side effect may be more of a concern for people who already have a weakened immune system. People who have HIV infection, have had an organ transplant and are taking medications to reduce the activity of the immune system, or are taking medication to treat certain types of cancer are more likely to have a weakened immune system. If any of these conditions apply to you, discuss with your doctor how Januvia (Sitagliptin) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Januvia (Sitagliptin), and whether any special monitoring is needed.
Kidney function: Januvia (Sitagliptin) has been reported to cause decreased kidney function and may cause kidney failure. Your doctor may recommend regular testing to check your kidney function while you are taking Januvia (Sitagliptin). If you notice signs of kidney problems, such as decreased urine production; swelling in your hands, wrists, feet, or ankles; difficulty breathing, or weakness, contact your doctor as soon as possible.
People with decreased kidney function may require lower doses of Januvia (Sitagliptin). If you have Kidney Disease or decreased kidney function, discuss with your doctor how Januvia (Sitagliptin) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Januvia (Sitagliptin), and whether any special monitoring is needed.
Januvia (Sitagliptin) is not recommended for people with moderately to severely reduced kidney function.
Liver function: Januvia (Sitagliptin) is not recommended for people with severely reduced liver function. People with moderately reduced liver function should discuss with their doctor how Januvia (Sitagliptin) may affect their medical condition, how their medical condition may affect the dosing and effectiveness of Januvia (Sitagliptin), and whether any special monitoring is needed.
Low blood glucose (sugar): Hypoglycemia (low blood sugar) can occur when Januvia (Sitagliptin) is used in combination with metformin and a sulfonylurea (e.g., glyburide, gliclazide), or insulin. If you experience low blood sugar (e.g., headache, drowsiness, weakness, dizziness, confusion, irritability, hunger, fast heartbeat, sweating, and feeling jittery) while taking Januvia (Sitagliptin), contact your doctor.
Pancreatitis: Januvia (Sitagliptin) may cause pancreatitis (inflammation of the pancreas). People with a history of pancreatitis, gallstones, Alcoholism, or high triglycerides may be more at risk of experiencing this. If you experience prolonged and severe abdominal pain with or without vomiting while taking Januvia (Sitagliptin), contact your doctor immediately.
Type 1 Diabetes and diabetic ketoacidosis: Januvia (Sitagliptin) should not be used by people with type 1 diabetes or to treat diabetic ketoacidosis (increased ketones in the blood or urine).
Pregnancy: Januvia (Sitagliptin) is not recommended for use during pregnancy. If you become pregnant while taking Januvia (Sitagliptin), contact your doctor immediately.
Breast-feeding: It is not known if Januvia (Sitagliptin) passes into breast milk. If you are a breast-feeding mother and are taking Januvia (Sitagliptin), it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.
Children: The safety and effectiveness of using Januvia (Sitagliptin) have not been established for children.
Seniors: Seniors are more likely to have decreased renal function and may require lower doses of Januvia (Sitagliptin).
Before you begin taking a medication, be sure to inform your doctor of any medical conditions or Allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use Onglyza (Saxagliptin).
Blood sugar control: If your body experiences stress such as fever, trauma, infection, or surgery, you may lose control of blood glucose. Your doctor may decide to temporarily stop Onglyza (Saxagliptin) and advise you to take insulin. Talk to your doctor if you have fever, infection, or are about to undergo surgery.
Congestive Heart Failure (CHF): Heart failure has been reported in people taking Onglyza (Saxagliptin). If you have CHF or heart disease, discuss with your doctor how Onglyza (Saxagliptin) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Onglyza (Saxagliptin), and whether Onglyza (Saxagliptin) is appropriate for you.
Galactose intolerance/glucose malabsorption: Onglyza (Saxagliptin) is prepared with lactose. If you have lactose or galactose intolerance speak with your doctor about whether Onglyza (Saxagliptin) is appropriate for you.
Hypoglycemia: Onglyza (Saxagliptin) may increase the risk of hypoglycemia (low blood sugar) when taking Onglyza (Saxagliptin) with a sulfonylurea or insulin. If you are taking Onglyza (Saxagliptin) with another medication to reduce blood sugar, your doctor may recommend a lower dose of the other medication.
If you experience low blood sugar (e.g., headache, drowsiness, weakness, dizziness, confusion, irritability, hunger, fast heartbeat, sweating, and feeling jittery) contact your doctor.
Immune system: If you have a weakened immune system (e.g., you have had an organ transplant or have HIV), discuss with your doctor how Onglyza (Saxagliptin) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Onglyza (Saxagliptin), and whether any special monitoring is needed.
Kidney function: Kidney Disease or reduced kidney function may cause Onglyza (Saxagliptin) to build up in the body, causing side effects. If you have reduced kidney function or kidney disease, discuss with your doctor how Onglyza (Saxagliptin) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Onglyza (Saxagliptin), and whether any special monitoring is needed.
Onglyza (Saxagliptin) may also cause reduced kidney function. Your doctor may recommend regular testing to check your kidney function while you are taking Onglyza (Saxagliptin). Onglyza (Saxagliptin) is not recommended for people with end-stage renal disease and those on dialysis.
Liver function: Liver disease or reduced liver function may cause Onglyza (Saxagliptin) to build up in the body, causing side effects. If you have liver problems, discuss with your doctor how Onglyza (Saxagliptin) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Onglyza (Saxagliptin), and whether any special monitoring is needed. Your doctor may want to test your liver function regularly with blood tests while you are taking Onglyza (Saxagliptin).
Onglyza (Saxagliptin) is not recommended for people with moderately or severely reduced liver function.
Pancreatitis: Onglyza (Saxagliptin) can cause the pancreas to become inflamed. If you have a history of pancreatitis, discuss with your doctor how Onglyza (Saxagliptin) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Onglyza (Saxagliptin), and whether any special monitoring is needed.
Report signs of pancreatitis such as abdominal pain on the upper left side, back pain, nausea, fever, chills, rapid heartbeat, or swollen abdomen to your doctor immediately.
Type 1 diabetes and diabetic ketoacidosis: Onglyza (Saxagliptin) should not be used to treat type 1 diabetes, diabetic pre-coma or coma, or diabetic ketoacidosis (increased ketones in the blood or urine).
Pregnancy: Onglyza (Saxagliptin) is not recommended for use during pregnancy. If you become pregnant while taking Onglyza (Saxagliptin), contact your doctor immediately.
Breast-feeding: It is not known if Onglyza (Saxagliptin) passes into breast milk. If you are a breast-feeding mother and are taking Onglyza (Saxagliptin), it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.
Children: The safety and effectiveness of using Onglyza (Saxagliptin) have not been established for children.
Seniors: People over the age of 65 may be more at risk of developing side effects from Onglyza (Saxagliptin).
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