Available in:Tablet
Dosage:25MG, 50MG, 100MG
Manufacturer:Merck
Available in:Tablet
Dosage:2.5MG, 5MG
Manufacturer:Pro Doc Limitée
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The usual dose of Januvia (Sitagliptin) is 100 mg taken by mouth once daily with or without food.
Many things can affect the dose of a medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.
It is important to take Januvia (Sitagliptin) exactly as prescribed by your doctor. If you miss a dose, take it as soon as possible and continue with your regular schedule. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.
Store Januvia (Sitagliptin) at room temperature and keep it out of the reach of children.
Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.
The recommended adult starting dose of glyburide is usually 5 mg daily (2.5 mg for patients over 60 years of age) and increases or decreases by 2.5 mg every 5 to 7 days until blood sugar is controlled. The recommended adult dose of glyburide ranges from 2.5 mg once daily to 10 mg twice daily. The maximum dose of glyburide is 20 mg daily.
Glyburide should be taken during or immediately after a meal, usually with breakfast or the first main meal of the day. If you eat only a light breakfast, wait until lunchtime to take your morning dose.
Many things can affect the dose of a medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.
Low blood sugar (Hypoglycemia) is an important concern if too much of Glyburide is taken. Ask your doctor or diabetes educator what you should do when you are not going to be eating for a long period of time or when you are going to be exercising more than usual.
It is very important to monitor blood sugar levels closely, especially when increasing and decreasing doses of medication or when exercise level or weight changes occur. Your doctor or diabetes educator will instruct you on the best use of a diabetes monitor.
It is important to take Glyburide exactly as prescribed by your doctor. If you miss a dose, take it as soon as possible and continue with your regular schedule. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.
Store Glyburide at room temperature, protect it from light and moisture and keep it out of reach of children.
Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.
Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.
The side effects listed below are not experienced by everyone who takes Januvia (Sitagliptin). If you are concerned about side effects, discuss the risks and benefits of Januvia (Sitagliptin) with your doctor.
The following side effects have been reported by at least 1% of people taking Januvia (Sitagliptin). Many of these side effects can be managed, and some may go away on their own over time.
Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.
Although most of these side effects listed below don't happen very often, they could lead to serious problems if you do not seek medical attention.
Check with your doctor as soon as possible if any of the following side effects occur:
Stop taking the medication and seek immediate medical attention if any of the following occur:
Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking Januvia (Sitagliptin).
Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.
The side effects listed below are not experienced by everyone who takes Glyburide. If you are concerned about side effects, discuss the risks and benefits of this medication with your doctor.
The following side effects have been reported by at least 1% of people taking Glyburide. Many of these side effects can be managed, and some may go away on their own over time.
Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.
Although most of these side effects listed below don't happen very often, they could lead to serious problems if you do not seek medical attention.
Check with your doctor as soon as possible if any of the following side effects occur:
Stop taking the medication and seek immediate medical attention if any of the following occur:
Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking Glyburide.
25 mg
Each pink, round, film-coated tablet, with "221" on one side, contains 25 mg of Januvia (Sitagliptin). Nonmedicinal ingredients: microcrystalline cellulose, anhydrous dibasic calcium phosphate (calcium hydrogen phosphate, anhydrous), croscarmellose sodium, magnesium stearate, and sodium stearyl fumarate; film coating: polyvinyl alcohol, polyethylene glycol (macrogol), talc, titanium dioxide, red iron oxide, and yellow iron oxide.
50 mg
Each light beige, round, film-coated tablet, with "112" on one side, contains 50 mg of Januvia (Sitagliptin). Nonmedicinal ingredients: microcrystalline cellulose, anhydrous dibasic calcium phosphate (calcium hydrogen phosphate, anhydrous), croscarmellose sodium, magnesium stearate, and sodium stearyl fumarate; film coating: polyvinyl alcohol, polyethylene glycol (macrogol), talc, titanium dioxide, red iron oxide, and yellow iron oxide.
100 mg
Each beige, round, film-coated tablet, with "277" on one side, contains 100 mg of Januvia (Sitagliptin). Nonmedicinal ingredients: microcrystalline cellulose, anhydrous dibasic calcium phosphate (calcium hydrogen phosphate, anhydrous), croscarmellose sodium, magnesium stearate, and sodium stearyl fumarate; film coating: polyvinyl alcohol, polyethylene glycol (macrogol), talc, titanium dioxide, red iron oxide, and yellow iron oxide.
Januvia (Sitagliptin) should not be taken by anyone who is allergic to Januvia (Sitagliptin) or to any of the ingredients of the medication.
Do not take glyburide if you:
There may be an interaction between Januvia (Sitagliptin) and any of the following:
If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:
An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.
Medications other than those listed above may interact with Januvia (Sitagliptin). Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.
There may be an interaction between glyburide and any of the following:
If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:
An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.
Medications other than those listed above may interact with Glyburide. Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the Nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.
Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use Januvia (Sitagliptin).
Hypersensitivity reaction: A Anaphylaxis (severe allergic reaction) called hypersensitivity reaction has occurred for some people with the use of Januvia (Sitagliptin). Stop taking the medication and get immediate medical attention if you have symptoms of a severe allergic reaction, including Fever, swollen glands, yellowing of the skin or eyes, or flu-like symptoms with skin rash or blistering.
Immune system: Januvia (Sitagliptin) can reduce the number of cells that fight infection in the body (white blood cells). This side effect may be more of a concern for people who already have a weakened immune system. People who have HIV infection, have had an organ transplant and are taking medications to reduce the activity of the immune system, or are taking medication to treat certain types of cancer are more likely to have a weakened immune system. If any of these conditions apply to you, discuss with your doctor how Januvia (Sitagliptin) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Januvia (Sitagliptin), and whether any special monitoring is needed.
Kidney function: Januvia (Sitagliptin) has been reported to cause decreased kidney function and may cause kidney failure. Your doctor may recommend regular testing to check your kidney function while you are taking Januvia (Sitagliptin). If you notice signs of kidney problems, such as decreased urine production; swelling in your hands, wrists, feet, or ankles; difficulty breathing, or weakness, contact your doctor as soon as possible.
People with decreased kidney function may require lower doses of Januvia (Sitagliptin). If you have Kidney Disease or decreased kidney function, discuss with your doctor how Januvia (Sitagliptin) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Januvia (Sitagliptin), and whether any special monitoring is needed.
Januvia (Sitagliptin) is not recommended for people with moderately to severely reduced kidney function.
Liver function: Januvia (Sitagliptin) is not recommended for people with severely reduced liver function. People with moderately reduced liver function should discuss with their doctor how Januvia (Sitagliptin) may affect their medical condition, how their medical condition may affect the dosing and effectiveness of Januvia (Sitagliptin), and whether any special monitoring is needed.
Low blood glucose (sugar): Hypoglycemia (low blood sugar) can occur when Januvia (Sitagliptin) is used in combination with metformin and a sulfonylurea (e.g., glyburide, gliclazide), or insulin. If you experience low blood sugar (e.g., headache, drowsiness, weakness, dizziness, confusion, irritability, hunger, fast heartbeat, sweating, and feeling jittery) while taking Januvia (Sitagliptin), contact your doctor.
Pancreatitis: Januvia (Sitagliptin) may cause pancreatitis (inflammation of the pancreas). People with a history of pancreatitis, gallstones, Alcoholism, or high triglycerides may be more at risk of experiencing this. If you experience prolonged and severe abdominal pain with or without vomiting while taking Januvia (Sitagliptin), contact your doctor immediately.
Type 1 Diabetes and diabetic ketoacidosis: Januvia (Sitagliptin) should not be used by people with type 1 diabetes or to treat diabetic ketoacidosis (increased ketones in the blood or urine).
Pregnancy: Januvia (Sitagliptin) is not recommended for use during pregnancy. If you become pregnant while taking Januvia (Sitagliptin), contact your doctor immediately.
Breast-feeding: It is not known if Januvia (Sitagliptin) passes into breast milk. If you are a breast-feeding mother and are taking Januvia (Sitagliptin), it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.
Children: The safety and effectiveness of using Januvia (Sitagliptin) have not been established for children.
Seniors: Seniors are more likely to have decreased renal function and may require lower doses of Januvia (Sitagliptin).
Before you begin taking a medication, be sure to inform your doctor of any medical conditions or Allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should take Glyburide.
Allergy: Some people who are allergic to sulfonamide antibiotics and other sulfonylurea anti-diabetes medications also experience allergic reactions to glyburide. Before you take glyburide, inform your doctor about any previous adverse reactions you have had to medications, especially sulfamethoxazole or glipizide. Contact your doctor at once if you experience signs of an allergic reaction, such as skin rash, itching, difficulty breathing or swelling of the face and throat.
Blood sugar control: For people who take glyburide, loss of blood sugar control may occur during illness or stressful situations such as trauma or surgery. Under these conditions, your doctor may consider stopping the medication and prescribing insulin until the situation improves.
Diabetes complications: The use of glyburide (or any other medication used for diabetes) will not prevent the development of complications peculiar to diabetes mellitus (e.g., Kidney Disease, nerve disease, eye disease).
Diet and exercise: Glyburide should be used in addition to a proper dietary regimen and exercise. If you do not follow a proper dietary and exercise regimen, it is more likely that glyburide will not work, and your diabetes will get worse.
Kidney function: If you have reduced kidney function or kidney disease, discuss with your doctor how Glyburide may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Glyburide, and whether any special monitoring is needed.
Liver function: Liver disease or reduced liver function may cause Glyburide to build up in the body, which will cause side effects. If you have liver problems, discuss with your doctor how Glyburide may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Glyburide, and whether any special monitoring is needed. Your doctor may want to test your liver function regularly with blood tests while you are taking Glyburide.
If you experience symptoms of liver problems such as fatigue, feeling unwell, loss of appetite, nausea, yellowing of the skin or whites of the eyes, dark urine, pale stools, abdominal pain or swelling, and itchy skin, contact your doctor immediately.
Low blood sugar: As with other sulfonylurea medications like Gliclazide or Glimepiride, hypoglycemia (low blood sugar) may occur. Situations which may bring this on include:
Signs of low blood sugar include:
Monitor your blood glucose regularly and keep emergency glucose (and a Glucagon kit) available in case you need to increase blood sugar levels quickly. Talk with your doctor or diabetes educator about this.
Mental or physical abilities: Glyburide may reduce the mental or physical abilities required for hazardous tasks such as driving or operating dangerous machinery. Use appropriate caution until you have gained control of your blood sugar, when changing doses of medication, or when the tablets have not been taken regularly.
Reduced response: Over time, glyburide may become less effective as your diabetes worsens. If glyburide fails to lower your blood glucose to target levels, it should be stopped and replaced, or another medication for diabetes should be added to it. Monitor your blood glucose levels regularly and if you notice them getting higher, contact your doctor to discuss alternatives.
Pregnancy: Glyburide should not be used during pregnancy. If you become pregnant while taking Glyburide, contact your doctor immediately.
Breast-feeding: Glyburide may pass into breast milk. If you are a breast-feeding mother and are taking glyburide, it may affect your baby. Glyburide is not recommended for use by breast-feeding women.
Children: The safety and effectiveness of using this medication have not been established for children under the age of 18.
Seniors: Seniors with type 2 diabetes may be more likely to experience very low blood sugar as a result of using glyburide. Lower doses may be necessary.
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