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Siliq

Siliq

(brodalumab)

Siliq (Brodalumab) belongs to the class of medications called biological response modifiers ("biologics"). It is used to treat moderate-to-severe plaque psoriasis in adults whose specialists have determined that systemic or phototherapy may be beneficial.

Available form

Dosage

Injectable Syringe

210MG/1.5ML

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Siliq information

Dosage

Side Effects

Available Form

Contraindications

Precautions

Warnings

The recommended starting dose of Siliq (Brodalumab) is 210 mg injected subcutaneously (under the skin) once a week for 3 weeks. After 3 doses, the recommended dose is 210 mg injected every 2 weeks. Each dose is given as a single injection of 210 mg (1.5 mL). Each syringe is single-use only and should be safely discarded after injecting the dose.

Siliq (Brodalumab) is administered by subcutaneous injection in the thigh, abdomen, or outer upper arm. It is important to rotate the site of injection. Avoid injecting into areas that are tender, bruised, red, hard, or affected by psoriasis.

Do not shake Siliq (Brodalumab) before using it. The solution for injection should be clear to slightly opalescent, and colourless-to-slightly-yellow. If it is cloudy or you can see lumps, flakes, or coloured particles in the solution, do not use it. To minimize discomfort, allow Siliq (Brodalumab) to warm to room temperature for 30 minutes before injecting.

If you are using Siliq (Brodalumab) at home, your doctor will ensure that you understand exactly how to use it. Make sure you ask any and all questions necessary to ensure that you use it exactly as prescribed. It is important to visit your doctor regularly during therapy to ensure that the medication is working safely and effectively.

Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.

It is important to take Siliq (Brodalumab) exactly as prescribed by your doctor.

If you miss a dose, inject it as soon as possible. Then talk to your doctor about when you should inject the next dose. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

Store Siliq (Brodalumab) in the refrigerator, protect it from light and moisture, and keep it out of the reach of children. Do not allow Siliq (Brodalumab) to freeze. Siliq (Brodalumab) may also be kept at room temperature in its original carton for up to 14 days.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

Before you begin using a medication, be sure to inform your doctor of any medical conditions or Allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use Siliq (Brodalumab).

Allergic reactions: In rare cases, some people may develop an allergic reaction to Siliq (Brodalumab). Signs of an allergic reaction include a severe rash, Hives, swollen face or throat, or difficulty breathing. If these occur, seek medical attention immediately.

Crohn's Disease: If you have Crohn's disease, (a form of inflammatory bowel disease) Siliq (Brodalumab) may make symptoms of this condition worse. During medication testing, some people with no history of Crohn's disease developed bowel symptoms. If you develop symptoms of inflammation in the digestive system, such as diarrhea, fatigue, fever, and abdominal pain or cramping, contact your doctor as soon as possible. People who have Crohn's disease should not use Siliq (Brodalumab).

Infections: Siliq (Brodalumab) can increase the risk of developing an infection, including serious infections such as sepsis, pneumonia, and Tuberculosis. Before starting Siliq (Brodalumab) treatment, your doctor may test to see if you have tuberculosis. If you notice signs of an infection such as fever, chills, pain, swelling, coughing, or pus, contact your doctor as soon as possible. Siliq (Brodalumab) should also not be started while you have an active infection.

Tell your doctor if you have a history of infections that keep coming back, or other conditions that might increase your risk of infections such as Diabetes. While you are taking Siliq (Brodalumab), your doctor will monitor you for signs of infection.

Suicidal or agitated behaviour: People with psoriasis appear to be at an increased risk of suicidal behaviour. If you have Depression or other mental illness, you may be at an increased risk of mood changes, feeling agitated (restless, anxious, aggressive, emotional, and feeling not like themselves), or wanting to hurt yourself or others. If you experience these side effects or notice them in a family member who is taking Siliq (Brodalumab), contact your doctor immediately.

Vaccines: Live vaccines (e.g., BCG, yellow fever) are not recommended for people taking Siliq (Brodalumab). Talk to your doctor if you need any vaccinations while taking Siliq (Brodalumab).

Pregnancy: Siliq (Brodalumab) should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking Siliq (Brodalumab), contact your doctor immediately.

Breast-feeding: It is not known if Siliq (Brodalumab) passes into breast milk. If you are a breast-feeding mother and are taking Siliq (Brodalumab), it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.

Children: The safety and effectiveness of using Siliq (Brodalumab) have not been established for children.

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