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Ilaris

Ilaris

(canakinumab)

Ilaris (Canakinumab) belongs to the class of medications called immunomodulatory agents. It reduces the activity of interleukin-1 beta (IL-1β), a chemical produced by the body as part of the body's defenses against infection, causing Fever, rash, swelling, and pain.

Available form

Dosage

Injectable Powder

150MG

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Ilaris information

Dosage

Side Effects

Available Form

Contraindications

Precautions

Warnings

Ilaris (Canakinumab) is given by subcutaneous (under the skin) injection, usually in the front of the thigh or abdomen. The dose depends on the condition being treated and is based on body weight. Your doctor will adjust your dose depending on how well you respond to and tolerate Ilaris (Canakinumab).

Ilaris (Canakinumab) is used with the guidance and supervision of a doctor. Your doctor or nurse will assist you in the preparation and injection of your first dose (or first few doses) and can teach you how to give yourself the injection at home. Do not attempt to inject Ilaris (Canakinumab) on your own until you completely understand how to inject a dose. If you are unsure of how to prepare or inject a dose, ask a health care professional to clarify for you. If you are having difficulty giving yourself injections, ask a family member or other caregiver for help if they are willing to become involved with your treatment and are willing to learn how to give you your injections.

Many things can affect the dose of a medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are using the medication without consulting your doctor.

It is important that Ilaris (Canakinumab) be taken exactly as prescribed by your doctor. If you miss a dose, take it as soon as possible, then contact your doctor to determine when you should take your next dose. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

Before injecting the medication, check the solution to ensure that it is clear and colourless and has no particles in it. If the solution is not clear and colourless, discard the syringe safely and use a new one. If the reconstituted solution is not used immediately, it may be stored in the refrigerator for up to 24 hours.

Store Ilaris (Canakinumab) in the refrigerator between 2°C and 8°C in its original packaging to protect it from light. Keep it out of sight and reach of children.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.

The side effects listed below are not experienced by everyone who takes Ilaris (Canakinumab). If you are concerned about side effects, discuss the risks and benefits of Ilaris (Canakinumab) with your doctor.

The following side effects have been reported by at least 1% of people taking Ilaris (Canakinumab). Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

abdominal pain
back pain
Diarrhea
dizziness
headache
heartburn
nausea
headache
redness, swelling, warmth, or itching at the injection site
spinning sensation
unexplained weakness or fatigue
vomiting

Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not check with your doctor or seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

cough that does not go away
fever, sore throat, or mouth sores
flu-like symptoms (sudden lack of energy, fever, cough, sore throat)
increased blood pressure
signs of bleeding (e.g., unusual nosebleeds, bruising, blood in urine, coughing blood, bleeding gums, cuts that don't stop bleeding)
signs of infection (symptoms may include fever or chills, severe diarrhea, shortness of breath, prolonged dizziness, headache, stiff neck, weight loss, or listlessness)
signs of liver problems (e.g., abdominal pain, dark urine or pale stools, easy bruising, yellow eyes or skin)
signs of vaginal yeast infection (e.g., vaginal odour, curd-like discharge, itching)
signs of pneumonia (e.g., fever, chills, shortness of breath, cough)
swollen lymph glands
symptoms of Tonsillitis (e.g., sore throat, fever, red or swollen tonsils cough, difficulty swallowing)
symptoms of a urinary tract infection (e.g. pain when urinating, urinating more often than usual, low back or flank pain)
worsening of arthritis symptoms in people with Systemic Juvenile Idiopathic Arthritis

Stop taking the medication and seek immediate medical attention if any of the following occur:

signs of a serious allergic reaction (e.g., abdominal cramps, difficulty breathing, nausea and vomiting, or swelling of the face and throat)

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking Ilaris (Canakinumab).

Before you begin using a medication, be sure to inform your doctor of any medical conditions or Allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use Ilaris (Canakinumab).

Cancer risks: People taking Ilaris (Canakinumab) may have a higher risk of developing certain types of cancer. Talk to your doctor about cancer screening and your risk of cancer.

Dizziness: Ilaris (Canakinumab) may cause dizziness or a spinning sensation, affecting your ability to drive or operate machinery. Avoid these and other hazardous tasks until you have determined how Ilaris (Canakinumab) affects you.

Serious infections: Ilaris (Canakinumab) can affect the way your body's natural defences work to fight infection. This makes the body more likely to develop infections due to bacteria, viruses, and fungi. This effect is increased if you are taking Ilaris (Canakinumab) with other medications that reduce the body's ability to fight infection. For some people, these infections have been fatal. If you have a history of chronic or frequent infections, discuss with your doctor how Ilaris (Canakinumab) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Ilaris (Canakinumab), and whether any special monitoring is needed.

Stop taking the medication and tell your doctor right away if you notice symptoms of a serious infection, such as fever, chills, headache, flu-like symptoms, feeling tired, cough, blood in the sputum, shortness of breath, night sweats, weight loss, nausea, vomiting, diarrhea, frequency or burning while passing urine, redness or swelling of skin or joint, Cold Sores, tooth pain, or new or worsening pain in any part of the body.

Tuberculosis: For people who have latent tuberculosis (TB) infection (the bacteria causing TB are alive in the body but are not active) the use of Ilaris (Canakinumab) may cause the tuberculosis bacteria to become active. Some people who have had tuberculosis (a lung infection) in the past have had this infection return when they are using Ilaris (Canakinumab). Your doctor will likely want to do a TB skin test before you begin using Ilaris (Canakinumab). If you have a history of tuberculosis, or have come into recent contact with someone who has tuberculosis, discuss with your doctor how Ilaris (Canakinumab) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Ilaris (Canakinumab), and whether any special monitoring is needed.

If you experience symptoms of TB such as unexplained weight loss, loss of appetite, fever, fatigue, chills or night sweats contact your doctor as soon as possible.

Vaccinations: People taking Ilaris (Canakinumab) should not receive certain vaccines. Talk to your doctor about whether any vaccines you are scheduled to take may be used with Ilaris (Canakinumab).

Pregnancy: Ilaris (Canakinumab) should not be used during pregnancy unless the benefits outweigh the risks. Women who may become pregnant while using Ilaris (Canakinumab) should use effective birth control while using Ilaris (Canakinumab) and for 3 months after the last dose. If you become pregnant while taking Ilaris (Canakinumab), contact your doctor immediately.

Breast-feeding: It is not known if Ilaris (Canakinumab) passes into breast milk. If you are a breast-feeding mother and are taking Ilaris (Canakinumab), it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.

Children: The safety and effectiveness of using Ilaris (Canakinumab) have not been established for children less than 2 years of age or those having a body weight of less than 9 kg.

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