Insulin is a naturally occurring hormone made by the pancreas that helps the body use or store the glucose (sugar) it gets from food. For people with Diabetes, either the pancreas does not make enough insulin to meet the body's requirements, or the body cannot properly use the insulin that is made. As a result, glucose cannot be used or stored properly and accumulates in the bloodstream. Insulin injected under the skin helps to lower blood glucose levels.

There are many different types of insulin and they are absorbed at different rates and work for varying periods of time. Regular insulin is a short-acting insulin. It takes 30 to 60 minutes to begin working after injection, and has its maximum effect between 2 and 4 hours after injection. It stops working after 6 to 8 hours. Concentrated regular insulin is used to improve blood glucose control for people with Type 1 or Type 2 Diabetes who require more than 200 units of insulin each day.

Entuzity Kwikpen (Insulin-human-regular) may be available under multiple brand names and/or in several different forms. Any specific brand name of Entuzity Kwikpen (Insulin-human-regular) may not be available in all of the forms or approved for all of the conditions discussed here. As well, some forms of Entuzity Kwikpen (Insulin-human-regular) may not be used for all of the conditions discussed here.

Your doctor may have suggested Entuzity Kwikpen (Insulin-human-regular) for conditions other than those listed in these drug information articles. If you have not discussed this with your doctor or are not sure why you are being given Entuzity Kwikpen (Insulin-human-regular), speak to your doctor. Do not stop using Entuzity Kwikpen (Insulin-human-regular) without consulting your doctor.

Do not give Entuzity Kwikpen (Insulin-human-regular) to anyone else, even if they have the same symptoms as you do. It can be harmful for people to use Entuzity Kwikpen (Insulin-human-regular) if their doctor has not prescribed it.

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Your required dose of regular insulin depends on how much natural insulin your pancreas is producing and how well your body is able to use it. Your doctor or diabetes educator will determine the appropriate dose for you according to various lifestyle factors and the blood glucose values obtained while monitoring your blood glucose.

Your dose of regular insulin should be injected subcutaneously (under the skin) exactly as instructed by your doctor or diabetes educator. Do not inject concentrated regular insulin into the vein and do not use concentrated regular insulin in insulin infusion pumps. The dose of insulin is measured in international units (IU). Each mL of concentrated regular insulin contains 500 IU. This insulin is injected about 30 minutes before eating a meal. Concentrated regular insulin should be clear and colourless. Do not use the insulin if you notice anything unusual in the appearance of the solution, such as cloudiness, discoloration, or clumping. Concentrated insulin should not be mixed with any other type of insulin. It should not be used in an insulin pump or injected into a vein or muscle.

Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones given here, do not change the way that you are using the medication without consulting your doctor.

It is very important that you use Entuzity Kwikpen (Insulin-human-regular) exactly as prescribed by your doctor. The timing of insulin with respect to your meals is crucial to keeping blood glucose under control and preventing unwanted side effects.

Keep unopened KwikPens in the refrigerator until needed. They may be used until the expiry date on the label. Never allow insulin to freeze. Insulin that is currently in use may be kept at room temperature for no more than 28 days and then discarded. Do not expose insulin to extremely hot temperatures or to sunlight. Keep insulin out of the reach of children.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.

The side effects listed below are not experienced by everyone who takes Entuzity Kwikpen (Insulin-human-regular). If you are concerned about side effects, discuss the risks and benefits of Entuzity Kwikpen (Insulin-human-regular) with your doctor.

The following side effects have been reported by at least 1% of people taking Entuzity Kwikpen (Insulin-human-regular). Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

• redness, itching, or swelling at the site of the injection

Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

• signs of low blood glucose:
• anxiety
• blurred vision
• confusion
• difficulty concentrating
• difficulty speaking
• dizziness
• drowsiness
• fast heartbeat
• headache
• hunger
• nausea
• nervousness
• numbness or tingling of the lips, fingers, or tongue
• sweating
• tiredness
• trembling
• weakness
• signs of low potassium levels in the blood (e.g., weakness, fatigue, muscle cramps, irregular heartbeat)
• symptoms of heart failure (e.g., swelling of the ankles and feet, shortness of breath, sudden weight gain)

Stop taking the medication and seek immediate medical attention if any of the following occur:

• rash or blisters all over body
• seizures
• symptoms of a serious allergic reaction (e.g., swelling of the face or throat, difficulty breathing, wheezing, or itchy skin rash)
• unconsciousness

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking Entuzity Kwikpen (Insulin-human-regular).

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Entuzity KwikPen
Each mL of clear, colourless, aqueous solution, contains 500 units of human biosynthetic insulin (regular insulin). Nonmedicinal ingredients: glycerin, metacresol, Zinc Oxide and water for injection. Hydrochloric acid and sodium hydroxide are used to adjust pH.

Do not use concentrated regular insulin if you:

• are allergic to insulin or to any of the ingredients of the medication
• have low blood glucose (Hypoglycemia)

Discreet Packaging

Your privacy is important. That's why we send your medication inside a plain delivery box so no one will know what's inside.

There may be an interaction between concentrated regular insulin and any of the following:

• alcohol
• anabolic steroids (e.g., testosterone)
• angiotensin converting enzyme inhitors (ACE inhibitors;(e.g., Ramipril, Enalapril, Lisinopril)
• second generation anti-psychotics (e.g., Clozapine, Olanzapine, Quetiapine)
• beta-blockers (e.g., Atenolol, Metoprolol, Pindolol, Propranolol, Sotalol)
• birth control pills
• chloroquine
• corticosteroids (e.g., Prednisone, Prednisolone)
• Dabrafenib
• Danazol
• decongestants (e.g., Pseudoephedrine)
• disopyromide
• diuretics (water pills; e.g., Furosemide, Hydrochlorothiazide, triamterene)
• Epinephrine
• estrogens (e.g., conjugated estrogen, Estradiol, ethinyl estradiol
• glucagon
• growth hormone
• hydroxychloroquine
• HIV protease inhibitors (e.g., atazanavir, indinavir, ritonavir, saquinavir)
• Lanreotide
• mifepristone
• monoamine oxidase inhibitors (M.O.S. e.g., Moclobemide, Phenelzine, Rasagiline, Selegiline, Tranylcypromine)
• Niacin
• Octreotide
• oral medications for diabetes (e.g., Canagliflozin, Gliclazide, Glyburide, Pioglitazone,  Metformin, Rosiglitazone)
• other insulins
• Pasireotide
• Pegvisomant
• Phenytoin
• progestins (e.g., Dienogest, Levonorgestrel, medroxyprogesterone, Norethindrone)
• quinine
• quinolone antibiotics (e.g., ciprofloxacin, Norfloxacin, Ofloxacin)
• salicylates (e.g., Asa)
• selective serotonin reuptake inhibitors (SSRIs; e.g., Citalopram, Fluoxetine, Paroxetine, Sertraline)
• Sirolimus
• somatostatin
• sulfa antibiotics (e.g., sulfamethoxazole, sulfadiazine)
• Sunitinib
• Tacrolimus
• thyroid replacement therapy (if beginning or changing dose)
• Vorinostat

If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

• stop taking one of the medications,
• change one of the medications to another,
• change how you are taking one or both of the medications, or
• leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with Entuzity Kwikpen (Insulin-human-regular). Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the Nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.

Before you begin using a medication, be sure to inform your doctor of any medical conditions or Allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use Entuzity Kwikpen (Insulin-human-regular).

Allergic reactions: If you notice signs of a serious allergic reaction (e.g., swelling of the face or throat, difficulty breathing, wheezing, or an itchy skin rash), stop taking the medication and seek immediate medical attention.

Appearance of insulin: The contents of the vial of regular insulin should be clear and colourless. Do not use Entuzity Kwikpen (Insulin-human-regular) if you notice anything unusual about its appearance, such as cloudiness, discoloration, or clumping.

Blood glucose monitoring: It is important for anyone using insulin to monitor their blood glucose levels regularly, as recommended by their doctor or diabetes educator. It is especially important to test blood glucose more often when your insulin dose or schedule changes, or when you are ill or under stress. If blood tests consistently show high or low blood glucose levels, contact your doctor or diabetes educator.

Changes at injection site: Fatty tissue under the skin at the injection site may shrink or thicken if you inject yourself too often at the same site. To help avoid this effect, change the site with each injection. Ideally, try not to use the same injection site more than once a month. Talk to your doctor or diabetes educator if you notice your skin pitting or thickening at the injection site.

Changes in insulin requirements: Many things can affect blood glucose levels and insulin requirements. These include:

• certain medical conditions (e.g., infections, Thyroid conditions, or kidney or liver disease)
• certain medications that increase or decrease blood glucose levels
• diet
• exercise
• illness
• injury
• stress
• surgery
• travelling over time zones

It is important your doctor knows your current health situation and any changes that may affect the amount of regular insulin you need. Blood glucose should be monitored regularly, as recommended by your doctor or diabetes educator.

Diabetes identification: It is important to either wear a bracelet (or necklace) or carry a card indicating you have diabetes and are taking insulin.

Family and friends: Educate your family and friends about the signs and symptoms of hypoglycemia (low blood glucose). Keep a Glucagon kit available and instruct them on its proper use in case you experience severe low blood glucose and lose consciousness.

High blood glucose (hyperglycemia): Hyperglycemia may occur if your insulin dose is too low or you miss a dose of insulin. Symptoms of hyperglycemia generally build up over hours or days. If you experience symptoms of hyperglycemia, such as increased need to urinate, nausea, vomiting, drowsiness, Dry Mouth, flushed dry skin, loss of appetite and a fruity odour to your breath, contact your doctor or diabetes educator.

If hyperglycemia is permitted to continue, a condition known as diabetic ketoacidosis may occur. In this condition, your body starts to use body fat as fuel, eventually leading to a large concentration of acid in the blood stream. This can result in unconsciousness, coma or death. To prevent this from occurring, you may need to have your insulin dose adjusted.

Kidney function: Kidney Disease or reduced kidney function may change the amount of insulin needed by the body. If you have kidney problems, discuss with your doctor how Entuzity Kwikpen (Insulin-human-regular) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Entuzity Kwikpen (Insulin-human-regular), and whether any special monitoring is needed. Your doctor may want to test your kidney function regularly with blood tests while you are taking Entuzity Kwikpen (Insulin-human-regular).

Liver function: Liver disease or reduced liver function may change the amount of insulin needed by the body. If you have liver problems, discuss with your doctor how Entuzity Kwikpen (Insulin-human-regular) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Entuzity Kwikpen (Insulin-human-regular), and whether any special monitoring is needed. Your doctor may want to test your liver function regularly with blood tests while you are taking Entuzity Kwikpen (Insulin-human-regular).

Low blood glucose (hypoglycemia): Hypoglycemia may occur if too much insulin is used, if meals are missed, or if you exercise more than usual. Symptoms of mild to moderate hypoglycemia may occur suddenly and can include cold sweat, nervousness or shakiness, fast heartbeat, headache, hunger, confusion, lightheadedness, weakness, and numbness or tingling of the tongue, lips, or fingers. Mild to moderate hypoglycemia may be treated by eating foods or drinks that contain sugar. People taking insulin should always carry a quick source of sugar, such as hard candies, glucose tablets, juice, or regular soft drinks (not diet soft drinks).

Signs of severe hypoglycemia can include disorientation, loss of consciousness, and seizures. People who are unable to take sugar by mouth or who are unconscious may require an injection of glucagon or treatment with intravenous (into the vein) glucose.

Potassium levels in the blood: Insulin can cause decreased potassium levels in the blood. Early signs of decreased potassium levels include muscle cramping in the arm or leg muscles, muscle weakness or tiredness, tingling or numbness, nausea or vomiting. In cases of severely reduced levels of potassium, Low Blood Pressure causing fainting and irregular heartbeat are possible. Report any of these symptoms to your doctor as soon as possible.

Pregnancy: It is essential to maintain good blood glucose control throughout pregnancy. Insulin requirements usually decrease during the first trimester and increase during the second and third trimesters.

Breast-feeding: Breast-feeding mothers may require adjustments in their insulin dose or diet.

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