Available in:Autoinjector
Dosage:0.75MG, 1.5MG
Manufacturer:Eli Lilly
Available in:Injectable Pen
Dosage:300MCG/1.2ML, 600MCG/2.4ML
Manufacturer:Astrazeneca
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The recommended adult starting dose of Trulicity (Dulaglutide) is 0.75 mg, injected subcutaneously (under the skin), once a week. It may be injected at any time of the day, without regard to meals. If necessary, your doctor may increase the dose to a maximum of 1.5 mg once weekly. Do not change your dose unless your doctor has told you to do so. Your doctor or diabetes educator will show you how to inject Trulicity (Dulaglutide).
If you are also using insulin, each medication should be injected separately. Trulicity (Dulaglutide) should be clear and colourless. Do not use Trulicity (Dulaglutide) if you notice anything unusual in the appearance of the solution, such as cloudiness, discolouration, or clumping.
Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.
It is important to take Trulicity (Dulaglutide) exactly as prescribed by your doctor. If you miss a dose, inject it as soon as possible and continue with your regular schedule. If it is less than 3 days until your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.
Store Trulicity (Dulaglutide) in the refrigerator; do not allow it to freeze. Protect it from direct heat and light. Keep this and all medication out of the reach of children. These single-use prefilled pens and syringes may be stored at room temperature for up to 14 days.
Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.
The usual starting dose of Byetta (Exenatide) is 5 µg (micrograms) injected subcutaneously (under the skin) in the thigh, abdomen, or upper arm twice daily. Inject Byetta (Exenatide) within 60 minutes before the morning and evening meal. You can also inject this medication before the 2 main meals of the day as long as they are at least 6 hours apart. Do not inject Byetta (Exenatide) after a meal.
The maximum dose is 10 µg twice daily. Byetta (Exenatide) is clear and colourless and should not contain particles. Do not use it if the solution appears cloudy or coloured.
Byetta (Exenatide) is available as a prefilled pen for injection. Read the user manual for instructions on how to properly use this medication. If you are not sure how to use Byetta (Exenatide), contact your doctor or pharmacist.
If you are taking a sulfonylurea (e.g., glyburide, gliclazide), your doctor may suggest a lower dose of the sulfonylurea when you are starting Byetta (Exenatide) or are increasing the dose.
Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are using the medication without consulting your doctor.
It is important that Byetta (Exenatide) be used exactly as prescribed by your doctor. If you miss a dose, skip the missed dose and continue with your regular dosing schedule. Do not use a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.
Before first use, store this medication in the refrigerator, protect it from light, and keep it out of the reach of children. Do not allow it to freeze.
After the first use, store Byetta (Exenatide) at room temperature. Discard any unused medication that is still in the pen 30 days after first use. Do not store this medication with the needle attached as this may cause the medication to leak.
Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.
Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.
The side effects listed below are not experienced by everyone who takes Trulicity (Dulaglutide). If you are concerned about side effects, discuss the risks and benefits of Trulicity (Dulaglutide) with your doctor.
The following side effects have been reported by at least 1% of people taking Trulicity (Dulaglutide). Many of these side effects can be managed, and some may go away on their own over time.
Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.
Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not seek medical attention.
Check with your doctor as soon as possible if any of the following side effects occur:
Stop taking the medication and seek immediate medical attention if any of the following occur:
Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking Trulicity (Dulaglutide).
Many medications can cause side effects. A side effect is an unwanted response to a medication when it is used in normal doses. Side effects can be mild or severe, temporary or permanent.
The side effects listed below are not experienced by everyone who uses Byetta (Exenatide). If you are concerned about side effects, discuss the risks and benefits of Byetta (Exenatide) with your doctor.
The following side effects have been reported by at least 1% of people taking Byetta (Exenatide). Many of these side effects can be managed, and some may go away on their own over time.
Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.
Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not check with your doctor or seek medical attention.
Check with your doctor as soon as possible if any of the following side effects occur:
Stop taking the medication and seek immediate medical attention if any of the following occur:
Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking Byetta (Exenatide).
0.75 mg/0.5 mL
Each single-use prefilled pen or prefilled syringe contains 0.75 mg of Trulicity (Dulaglutide) per 0.5 mL of solution. Nonmedicinal ingredients: trisodium citrate dehydrate, citric acid anhydrous, mannitol, and polysorbate 80 in water for injection.
1.5 mg/0.5 mL
Each single-use prefilled pen or prefilled syringe contains 1.5 mg of Trulicity (Dulaglutide) per 0.5 mL of solution. Nonmedicinal ingredients: trisodium citrate dehydrate, citric acid anhydrous, mannitol, and polysorbate 80 in water for injection.
Each mL of sterile, preserved solution contains Byetta (Exenatide) 250 µg. Non-medicinal ingredients: m-cresol (2.20 mg), mannitol, glacial acetic acid, sodium acetate trihydrate, and water for injection. Available as prefilled pens: 1.2 mL prefilled pen (60 doses of 5 µg/dose) and 2.4 mL prefilled pen (60 doses of 10 µg/dose).
Do not take Trulicity (Dulaglutide) if you:
Do not use Byetta (Exenatide) if you:
There may be an interaction between Trulicity (Dulaglutide) and any of the following:
If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:
An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.
Medications other than those listed above may interact with Trulicity (Dulaglutide). Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the Nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.
There may be an interaction between Byetta (Exenatide) and any of the following:
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If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:
An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.
Medications other than those listed above may interact with Byetta (Exenatide). Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the Nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.
Before you begin using a medication, be sure to inform your doctor of any medical conditions or Allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health.
Diabetes identification: It is important to either wear a bracelet (or necklace) or carry a card indicating you have diabetes and are taking medication to manage your blood glucose levels.
Heart problems: Trulicity (Dulaglutide) may increase heart rate and may affect how electrical impulses travel through the heart muscle. If you have heart disease (e.g., recent Heart Attack, Angina, heart failure) or an abnormal heart rhythm (e.g., heart block or fast heart rate), discuss with your doctor how Trulicity (Dulaglutide) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Trulicity (Dulaglutide), and whether any special monitoring is needed.
Intestinal problems: The safety and effectiveness of using Trulicity (Dulaglutide) have not been established for people who have problems with slowed movement of food through the digestive tract. If you have digestive system problems, discuss with your doctor how Trulicity (Dulaglutide) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Trulicity (Dulaglutide), and whether any special monitoring is needed.
Kidney function: The safety and effectiveness of using Trulicity (Dulaglutide) for people with reduced kidney function has not been studied. Ensure that you are drinking enough water to prevent dehydration if you experience nausea or vomiting with Trulicity (Dulaglutide). If you have reduced kidney function or Kidney Disease, discuss with your doctor how Trulicity (Dulaglutide) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Trulicity (Dulaglutide), and whether any special monitoring is needed.
Liver function: The safety and effectiveness of using Trulicity (Dulaglutide) for people with reduced liver function have not been studied. If you have reduced liver function or liver disease, discuss with your doctor how Trulicity (Dulaglutide) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Trulicity (Dulaglutide), and whether any special monitoring is needed.
Low blood glucose (Hypoglycemia): People who use Trulicity (Dulaglutide) and are also taking a sulfonylurea (e.g., Glyburide, Gliclazide) or insulin to control high blood sugar are more at risk of experiencing hypoglycemia (low blood sugar). If you experience symptoms of hypoglycemia such as a cold sweat, nervousness or shakiness, fast heartbeat, headache, hunger, confusion, lightheadedness, weakness, and numbness or tingling of the tongue or lips, contact your doctor. Your doctor may need to adjust the dose of your medication(s).
Pancreatitis (inflammation of the pancreas): Trulicity (Dulaglutide) can cause pancreatitis. If you experience symptoms of pancreatitis such as severe and persistent abdominal pain that may move to the back with or without vomiting, contact your doctor immediately. If you have previously had pancreatitis, discuss with your doctor how Trulicity (Dulaglutide) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Trulicity (Dulaglutide), and whether any special monitoring is needed.
Risk of thyroid cancer: In rare cases, people have developed thyroid cancer while using Trulicity (Dulaglutide). People with a personal or family history of thyroid cancer or people who have multiple endocrine neoplasia syndrome type 2 (a disease where people have tumours in more than one gland in their body) should not use Trulicity (Dulaglutide). If you develop symptoms of a thyroid tumour, such as difficulty swallowing, a mass in the neck or persistent hoarseness, contact your doctor as soon as possible.
Pregnancy: Trulicity (Dulaglutide) should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking Trulicity (Dulaglutide), contact your doctor immediately.
If you are planning to become pregnant, talk to your doctor about discontinuing Trulicity (Dulaglutide). You should not become pregnant for at least 4 weeks after stopping Trulicity (Dulaglutide), to give the medication enough time to completely leave the body.
Breast-feeding: It is not known if Trulicity (Dulaglutide) passes into breast milk. If you are a breast-feeding mother and are taking Trulicity (Dulaglutide), it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.
Children: The safety and effectiveness of using Trulicity (Dulaglutide) have not been established for children.
Before you begin using a medication, be sure to inform your doctor of any medical conditions or Allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use Byetta (Exenatide).
Blood sugar control: If you have a Fever, an infection, surgery, or trauma, you may experience a loss of blood sugar control and may need to stop Byetta (Exenatide) and use insulin until you recover. Your doctor will recommend when this is needed.
Diabetes identification: It is important to either wear a bracelet (or necklace) or carry a card indicating you have diabetes and are taking medication to manage your blood glucose levels.
Electrolytes (e.g., potassium and magnesium): If you have low blood potassium or magnesium levels or have a condition that could result in dehydration (e.g., diarrhea, vomiting), discuss with your doctor how Byetta (Exenatide) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.
Heart problems: Byetta (Exenatide) may increase your heart rate and may affect how electrical impulses travel through the heart muscle. If you have heart disease (e.g., recent Heart Attack, Angina, heart failure) or an abnormal heart rhythm (e.g., heart block or fast heart rate), discuss with your doctor how Byetta (Exenatide) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Byetta (Exenatide), and whether any special monitoring is needed.
If you experience dizziness, palpitations (a rapid, pounding, or irregular heartbeat), fainting or seizures, get immediate medical attention.
Kidney problems: This medication may cause kidney problems. Your doctor will monitor your kidney function with blood tests while you are using Byetta (Exenatide). If you have had a kidney transplant or have reduced kidney function, discuss with your doctor how Byetta (Exenatide) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Byetta (Exenatide), and whether any special monitoring is needed. If you are on dialysis or have severely reduced kidney function, you should not use Byetta (Exenatide).
Low blood sugar (Hypoglycemia): Byetta (Exenatide) may cause low blood sugar when it is used with sulfonylureas (e.g., glyburide, gliclazide) or insulin. If you are taking any of these types of medications, discuss with your doctor how Byetta (Exenatide) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Byetta (Exenatide), and whether any special monitoring is needed.
You may also be more at risk of experiencing low blood sugar levels if you have pituitary or adrenal failure, have an eating disorder, are on a diet, skip a meal, exercise intensely, or drink excessive amounts of alcohol.
If you experience symptoms of hypoglycemia such as a cold sweat, nervousness or shakiness, fast heartbeat, headache, hunger, confusion, lightheadedness, weakness, and numbness or tingling of the tongue or lips, contact your doctor. Your doctor may need to adjust the dose of your medication(s).
Pancreatitis (inflammation of the pancreas): Byetta (Exenatide) may cause pancreatitis that can be serious or life threatening. If you experience symptoms of pancreatitis such as severe and persistent abdominal pain that may move to your back and may be accompanied by vomiting, stop taking Byetta (Exenatide) and contact your doctor or get immediate medical attention.
If you have previously had pancreatitis, gallstones, or alcohol use problems, discuss with your doctor how Byetta (Exenatide) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Byetta (Exenatide), and whether any special monitoring is needed.
Stomach and intestinal problems: The safety and effectiveness of using Byetta (Exenatide) for people with inflammatory bowel disease (e.g., Crohn's Disease, Ulcerative Colitis) or who have slowed movement through the intestinal tract due to diabetes have not been established. If you have any of these conditions, you should not use this medication.
Thyroid cancer: If you or a family member have ever had medullary thyroid cancer or Multiple Endocrine Neoplasia syndrome type 2 (MEN 2), you should not use Byetta (Exenatide).
Weight loss: Byetta (Exenatide) may cause weight loss. If you experience weight loss of more than 1.5 kilograms (3.3 pounds) per week, contact your doctor. Losing weight this quickly can be harmful.
Pregnancy: Byetta (Exenatide) should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while using Byetta (Exenatide), contact your doctor immediately.
Breast-feeding: It is not known if Byetta (Exenatide) passes into breast milk. If you are a breast-feeding mother and are taking Byetta (Exenatide), it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.
Children: The safety and effectiveness of using Byetta (Exenatide) have not been established for children and adolescents less than 18 years of age.
Seniors: If you are a senior, you may be more sensitive to the effects of this medication and be more likely to experience side effects.
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