Ozempic-vs-Januvia

Ozempic (semaglutide)

Ozempic (Semaglutide) belongs to a group of medications known as glucagon-like peptide-1 (GLP-1) receptor agonists. It is used alone or with other medications to improve blood glucose (sugar) levels for people with Type 2 Diabetes.

Available in:Injectable Pen

Dosage:0.25mg, 0.5mg, 1mg

Manufacturer:Novo Nordisk

Januvia (sitagliptin)

Januvia (Sitagliptin) belongs to the group of Diabetes medications called DPP-4 inhibitors. It works by increasing the amount of incretin released by the intestine.

Available in:Tablet

Dosage:25MG, 50MG, 100MG

Manufacturer:Merck

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Dosage

Side Effects

Available Form

Contraindications

Precautions

Warnings

Ozempic

Each 1 mL of clear, colourless solution contains 1.34 mg of Ozempic (Semaglutide). Nonmedicianl ingredients: disodium phosphate dihydrate, propylene glycol, phenol, and water for injections.

There are 2 forms of the pre-filled, multi-dose, disposable pen. One pen delivers doses of 0.25 mg and 0.5 mg Ozempic (Semaglutide), while the other pen delivers 1 mg doses only.

Each pen contains 2 mg of Ozempic (Semaglutide).

Januvia

The usual dose of Januvia (Sitagliptin) is 100 mg taken by mouth once daily with or without food.

Many things can affect the dose of a medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.

It is important to take Januvia (Sitagliptin) exactly as prescribed by your doctor. If you miss a dose, take it as soon as possible and continue with your regular schedule. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

Store Januvia (Sitagliptin) at room temperature and keep it out of the reach of children.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

Ozempic

Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.

The side effects listed below are not experienced by everyone who takes Ozempic (Semaglutide). If you are concerned about side effects, discuss the risks and benefits of Ozempic (Semaglutide) with your doctor.

The following side effects have been reported by at least 1% of people taking Ozempic (Semaglutide). Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

change in the taste of food or drink
Constipation
decreased appetite
Diarrhea
dizziness
gas or burping
heartburn
mild abdominal pain or bloating
nausea
redness, itching, or swelling at the injection site
tiredness
vomiting
weight loss

Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

signs of low blood glucose (e.g., anxiety, blurred vision, confusion, difficulty concentrating, difficulty speaking, dizziness, drowsiness, fast heartbeat, feeling jittery, headache, hunger, irritability, nausea, nervousness, numbness or tingling of the lips or tongue, sweating, tiredness, trembling, weakness)
symptoms of gallstones (e.g., intermittent, severe, dull pain in the upper right part of the abdomen, nausea, vomiting, intolerance of fatty or greasy foods)
symptoms of irregular heartbeat (e.g., chest pain, dizziness, rapid, pounding heartbeat, shortness of breath)
vision changes caused by diabetic retinopathy (e.g., blurred or changing vision, floaters, changes in colour vision)

Stop taking the medication and seek immediate medical attention if any of the following occur:

severe Hypoglycemia (e.g., disorientation, loss of consciousness, seizures)
signs of pancreatitis (e.g., abdominal pain on the upper left side, back pain, nausea, Fever, chills, rapid heartbeat, swollen abdomen)
symptoms of a serious allergic reaction (e.g., swelling of the face or throat, difficulty breathing, wheezing, or itchy skin rash)

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking Ozempic (Semaglutide).

Januvia

Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.

The side effects listed below are not experienced by everyone who takes Januvia (Sitagliptin). If you are concerned about side effects, discuss the risks and benefits of Januvia (Sitagliptin) with your doctor.

The following side effects have been reported by at least 1% of people taking Januvia (Sitagliptin). Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

arm, leg, or back pain
Constipation
headache
itching
muscle pain
nausea
sore throat
stuffy or runny nose
vomiting

Although most of these side effects listed below don't happen very often, they could lead to serious problems if you do not seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

joint pain
skin blisters
symptoms of low blood sugar (e.g., headache, drowsiness, weakness, dizziness, confusion, irritability, hunger, fast heartbeat, sweating, and feeling jittery)
symptoms of kidney problems (e.g., nausea, loss of appetite, weakness, shortness of breath, passing little or no urine)

Stop taking the medication and seek immediate medical attention if any of the following occur:

severe skin reaction (blistering, peeling, skin breakdown)
symptoms of pancreatitis (e.g., prolonged, severe abdominal pain with or without vomiting)
symptoms of a serious allergic reaction (such as swelling of the face, lips, tongue, or throat; skin rash; Hives; or difficulty breathing)

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking Januvia (Sitagliptin).

Ozempic

There may be an interaction between Ozempic (Semaglutide) and any of the following:

acetylsalicylic acid (Asa)
androgens (e.g., testosterone)
atypical antipsychotics (e.g., Clozapine, Olanzapine, Quetiapine, Risperidone)
inhaled corticosteroids (e.g., budesonide, ciclesonide, fluticasone)
oral corticosteroids (e.g., Dexamethasone, Hydrocortisone, Prednisone)
Dabrafenib
Danazol
Disopyramide
diuretics (water pills; e.g., Furosemide, Hydrochlorothiazide, triamterene)
estrogens (e.g., conjugated estrogen, Estradiol, ethinyl estradiol)
Glucagon
HIV protease inhibitors (e.g., atazanavir, indinavir, ritonavir, saquinavir)
Lanreotide
Leuprolide
mifepristone
monoamine oxidase inhibitors (M.O.S. e.g., Moclobemide, Phenelzine, Rasagiline, Selegiline, Tranylcypromine)
Niacin
Octreotide
other diabetes medications (e.g., chlorpropamide, glipizide, glyburide, insulin, metformin, Rosiglitazone)
Pasireotide
Pegvisomant
pentamidine
progestins (e.g., Dienogest, Levonorgestrel, medroxyprogesterone, Norethindrone)
quinine
quinolone antibiotics (e.g., ciprofloxacin, Norfloxacin, Ofloxacin)
selective serotonin reuptake inhibitors (SSRIs; e.g., Citalopram, Fluoxetine, Paroxetine, Sertraline)
sulfonamide antibiotics ("sulfas"; e.g., sulfisoxazole, sulfamethoxazole)
Sunitinib
Tacrolimus
Vorinostat

If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

stop taking one of the medications,
change one of the medications to another,
change how you are taking one or both of the medications, or
leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with Ozempic (Semaglutide). Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the Nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.

All material copyright MediResource Inc. 1996-2021. Terms and conditions of use. The contents herein are for informational purposes only. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. Source: www.medbroadcast.com/drug/getdrug/Ozempic

Januvia

There may be an interaction between Januvia (Sitagliptin) and any of the following:

acetazolamide
alcohol
alpha-lipoic acids
angiotensin converting enzyme inhibitors (ACEIs; captopril, enalapril, ramipril)
antimalarial medications (e.g., hydroxychloroquine, quinine)
antipsychotics (e.g., aripiprazole, clozapine, quetiapine, risperidone)
beta-blockers (e.g., acebutolol, carvedilol, metoprolol, propranolol)
bismuth subsalicylate
buserelin
cancer medications (e.g., belzutifan, bortezomib, vorinostat)
cephalexin
cimetidine
corticosteroids (e.g., betamethasone, dexamethasone, fludrocortisone, prednisolone)
danazol
disopyramide
diuretics (water pills; e.g., furosemide, hydrochlorothiazide)
diabetes medications (e.g., gliclazide, insulin, repaglinide)
elagolix
epinephrine
estrogens (e.g., conjugated estrogen, estradiol, ethinyl estradiol)
everolimus
glucagon
glycopyrrolate
goserelin
Hepatitis C antivirals (e.g., glecaprevir, ledipasvir, voxilaprevir)
HIV integrase inhibitors (e.g., bictegravir, dolutegravir)
HIV protease inhibitors (e.g., atazanavir, darunavir, ritonavir)
hydroxychloroquine
lamotrigine
leuprolide
linezolid
megestrol
methazolamide
mifepristone
monoamine oxidase inhibitors (MAOIs; e.g., moclobemide, phenelzine, rasagiline, selegiline, tranylcypromine)
nicotinic acid (niacin)
nonsteroidal anti-inflammatory drugs (NSAIDs; e.g., celecoxib, diclofenac, ibuprofen, ketorolac, naproxen)
patiromer
pegvisomant
pentamidine
progestins (e.g., dienogest, levonorgestrel, medroxyprogesterone, norethindrone)
protein kinase inhibitors (e.g., ceritinib, nilotinib, sunitinib)
quinolone antibiotics (e.g., ciprofloxacin, norfloxacin, ofloxacin)
ranolazine
selective serotonin reuptake inhibitors (SSRIs; e.g., citalopram, fluoxetine, paroxetine, sertraline)
sirolimus
somatostatin-like medications (e.g., lanreotide, octreotide, pasireotide)
somatropin
"statin" anti-cholesterol medications (e.g., atorvastatin, lovastatin, simvastatin)
sulfamethoxazole
tacrolimus
terbutaline
testosterone
topiramate
tramadol
triptorelin
trimethoprim
verapamil

If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

stop taking one of the medications,
change one of the medications to another,
change how you are taking one or both of the medications, or
leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with Januvia (Sitagliptin). Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.

Ozempic

Before you begin using a medication, be sure to inform your doctor of any medical conditions or Allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use Ozempic (Semaglutide).

Diabetes identification: It is important to either wear a bracelet (or necklace) or carry a card indicating you have diabetes and are taking medication to manage your blood glucose levels.

Heart problems: Ozempic (Semaglutide) may increase heart rate and may affect how electrical impulses travel through the heart muscle. If you have heart disease or an abnormal heart rhythm (e.g., heart block or fast heart rate), discuss with your doctor how Ozempic (Semaglutide) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Ozempic (Semaglutide), and whether any special monitoring is needed.

Kidney function: Ozempic (Semaglutide) may cause decreased kidney function, kidney failure or worsening chronic kidney failure. If you have reduced kidney function or Kidney Disease, discuss with your doctor how Ozempic (Semaglutide) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Ozempic (Semaglutide), and whether any special monitoring is needed.

Low blood glucose (hypoglycemia): People who use Ozempic (Semaglutide) and are also taking a sulfonylurea (e.g., glyburide, Gliclazide) or insulin to control high blood sugar are more at risk of experiencing hypoglycemia (low blood sugar). If you experience symptoms of hypoglycemia such as a cold sweat, nervousness or shakiness, fast heartbeat, headache, hunger, confusion, lightheadedness, weakness, and numbness or tingling of the tongue or lips, contact your doctor. Your doctor may need to adjust the dose of your medication(s).

Pancreatitis (inflammation of the pancreas): Ozempic (Semaglutide) can cause pancreatitis. If you experience symptoms of pancreatitis such as severe and persistent abdominal pain that may move to the back with or without vomiting, contact your doctor immediately. If you have previously had pancreatitis, discuss with your doctor how Ozempic (Semaglutide) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Ozempic (Semaglutide), and whether any special monitoring is needed.

Risk of thyroid cancer: In rare cases, people have developed thyroid cancer while using medications similar to Ozempic (Semaglutide). People with a personal or family history of thyroid cancer or people who have multiple endocrine neoplasia syndrome type 2 (a disease where people have tumours in more than one gland in their body) should not use Ozempic (Semaglutide). If you develop difficulty swallowing or breathing, hoarseness or notice a mass developing in your neck, contact your doctor as soon as possible.

Pregnancy: Ozempic (Semaglutide) should not be used during pregnancy. If you become pregnant while using Ozempic (Semaglutide), contact your doctor immediately.

Breast-feeding: It is not known if Ozempic (Semaglutide) passes into breast milk. If you are a breast-feeding mother and are taking Ozempic (Semaglutide), it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.

Children: The safety and effectiveness of using Ozempic (Semaglutide) have not been established for children.

Januvia

Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use Januvia (Sitagliptin).

Hypersensitivity reaction: A Anaphylaxis (severe allergic reaction) called hypersensitivity reaction has occurred for some people with the use of Januvia (Sitagliptin). Stop taking the medication and get immediate medical attention if you have symptoms of a severe allergic reaction, including Fever, swollen glands, yellowing of the skin or eyes, or flu-like symptoms with skin rash or blistering.

Immune system: Januvia (Sitagliptin) can reduce the number of cells that fight infection in the body (white blood cells). This side effect may be more of a concern for people who already have a weakened immune system. People who have HIV infection, have had an organ transplant and are taking medications to reduce the activity of the immune system, or are taking medication to treat certain types of cancer are more likely to have a weakened immune system. If any of these conditions apply to you, discuss with your doctor how Januvia (Sitagliptin) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Januvia (Sitagliptin), and whether any special monitoring is needed.

Kidney function: Januvia (Sitagliptin) has been reported to cause decreased kidney function and may cause kidney failure. Your doctor may recommend regular testing to check your kidney function while you are taking Januvia (Sitagliptin). If you notice signs of kidney problems, such as decreased urine production; swelling in your hands, wrists, feet, or ankles; difficulty breathing, or weakness, contact your doctor as soon as possible.

People with decreased kidney function may require lower doses of Januvia (Sitagliptin). If you have Kidney Disease or decreased kidney function, discuss with your doctor how Januvia (Sitagliptin) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Januvia (Sitagliptin), and whether any special monitoring is needed.

Januvia (Sitagliptin) is not recommended for people with moderately to severely reduced kidney function.

Liver function: Januvia (Sitagliptin) is not recommended for people with severely reduced liver function. People with moderately reduced liver function should discuss with their doctor how Januvia (Sitagliptin) may affect their medical condition, how their medical condition may affect the dosing and effectiveness of Januvia (Sitagliptin), and whether any special monitoring is needed.

Low blood glucose (sugar): Hypoglycemia (low blood sugar) can occur when Januvia (Sitagliptin) is used in combination with metformin and a sulfonylurea (e.g., glyburide, gliclazide), or insulin. If you experience low blood sugar (e.g., headache, drowsiness, weakness, dizziness, confusion, irritability, hunger, fast heartbeat, sweating, and feeling jittery) while taking Januvia (Sitagliptin), contact your doctor.

Pancreatitis: Januvia (Sitagliptin) may cause pancreatitis (inflammation of the pancreas). People with a history of pancreatitis, gallstones, Alcoholism, or high triglycerides may be more at risk of experiencing this. If you experience prolonged and severe abdominal pain with or without vomiting while taking Januvia (Sitagliptin), contact your doctor immediately.

Type 1 Diabetes and diabetic ketoacidosis: Januvia (Sitagliptin) should not be used by people with type 1 diabetes or to treat diabetic ketoacidosis (increased ketones in the blood or urine).

Pregnancy: Januvia (Sitagliptin) is not recommended for use during pregnancy. If you become pregnant while taking Januvia (Sitagliptin), contact your doctor immediately.

Breast-feeding: It is not known if Januvia (Sitagliptin) passes into breast milk. If you are a breast-feeding mother and are taking Januvia (Sitagliptin), it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.

Children: The safety and effectiveness of using Januvia (Sitagliptin) have not been established for children.

Seniors: Seniors are more likely to have decreased renal function and may require lower doses of Januvia (Sitagliptin).

Ozempic (semaglutide)

Januvia (sitagliptin)

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