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Pifeltro

Pifeltro

Doravirine belongs to a class of medications called antiretroviral agents and more specifically, to the class of medications called non-nucleoside reverse transcriptase inhibitors (NNRTIs). Reverse transcriptase is an enzyme that is needed by human immunodeficiency virus (HIV) for reproduction.

Available form

Dosage

Tablet

100MG

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Pifeltro information

Dosage

Side Effects

Available Form

Contraindications

Precautions

Warnings

The recommended adult dose of doravirine is 100 mg taken by mouth, once daily. It may be taken with or without food.

Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.

It is important to take Pifeltro exactly as prescribed by your doctor.

If you miss a dose, take it as soon as possible and continue with your regular schedule. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

Store Pifeltro in the original bottle at room temperature, protect it from light and moisture, and keep it out of the reach of children.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

Before you begin using a medication, be sure to inform your doctor of any medical conditions or Allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use Pifeltro.

Blood sugar: Doravirine may cause an increase in blood sugar levels (may cause a loss of blood glucose control) and glucose tolerance may change. People with Diabetes may find it necessary to monitor their blood sugar more frequently while using Pifeltro.

If you have diabetes or are at risk for developing diabetes, discuss with your doctor how Pifeltro may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Pifeltro, and whether any special monitoring is needed.

Cholesterol: Doravirine can cause increased blood cholesterol levels. If you are at risk of developing High Cholesterol or you have high cholesterol levels before starting doravirine, discuss with your doctor how Pifeltro may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Pifeltro, and whether any special monitoring is needed.

Drowsiness/reduced alertness: Doravirine may cause drowsiness or dizziness, affecting your ability to drive or operate machinery. Avoid driving, operating machinery, or performing other potentially hazardous tasks until you have determined how you are affected by Pifeltro.

Immune reconstitution syndrome: Pifeltro may cause immune reconstitution syndrome, where signs and symptoms of inflammation from previous infections appear. These symptoms occur soon after starting anti-HIV medication and can vary. They are thought to occur as a result of the immune system improving and being able to fight infections that have been present without symptoms (such as pneumonia, herpes, or Tuberculosis). Report any new symptoms to your doctor immediately.

Stopping the medication: If you stop taking Pifeltro, your HIV infection could get worse. Take the medication exactly as prescribed by your doctor, and do not stop taking the medication without checking with your doctor first.

Pregnancy: Pifeltro should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking Pifeltro, contact your doctor immediately.

Breast-feeding: It is not known if doravirine passes into breast milk. Women who have HIV infection should not breast-feed because of the risk of passing HIV to a baby who does not have the infection.

Children: The safety and effectiveness of using Pifeltro have not been established for children.

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