Brimonidine belongs to the class of medications called selective alpha-2 adrenergic agonists. It is used to treat the redness of the skin that is caused by a condition called Rosacea.

This medication works by narrowing the blood vessels in the skin to reduce the redness caused by rosacea. Brimonidine topical gel often begins to work within 30 minutes of applying it to the affected skin. The maximum effect is frequently seen approximately 3 hours after application.

Onreltea (Brimonidine-topical) may be available under multiple brand names and/or in several different forms. Any specific brand name of Onreltea (Brimonidine-topical) may not be available in all of the forms or approved for all of the conditions discussed here. As well, some forms of Onreltea (Brimonidine-topical) may not be used for all of the conditions discussed here.

Your doctor may have suggested Onreltea (Brimonidine-topical) for conditions other than those listed in these drug information articles. If you have not discussed this with your doctor or are not sure why you are taking Onreltea (Brimonidine-topical), speak to your doctor. Do not stop taking Onreltea (Brimonidine-topical) without consulting your doctor.

Do not give Onreltea (Brimonidine-topical) to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take this medication if their doctor has not prescribed it.

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The recommended dose of brimonidine topical gel is approximately 1 gram of gel applied once daily. Five small pea-size amounts, totalling approximately 1 gram, should be applied evenly to each of the five areas of the face (chin, nose, forehead and each cheek). This is the maximum daily dose. Avoid the eye and lip areas. Do not apply to open wounds or irritated skin.

Wash your hands immediately after applying the gel. Make-up may be used after applying the gel.

Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.

It is important that Onreltea (Brimonidine-topical) be used exactly as prescribed by your doctor. If you do not notice any improvement within 5 days, contact your doctor. Do not apply Onreltea (Brimonidine-topical) more frequently than your doctor recommends.

If you miss a dose, apply it as soon as possible and continue with your regular schedule. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not apply a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

Store Onreltea (Brimonidine-topical) at room temperature, protect it from light and moisture, and keep it out of the reach of children.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.

The side effects listed below are not experienced by everyone who takes Onreltea (Brimonidine-topical). If you are concerned about side effects, discuss the risks and benefits of Onreltea (Brimonidine-topical) with your doctor.

The following side effects have been reported by at least 1% of people taking this medication. Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

• Acne
• Dry Mouth
• dry skin
• feeling cold in the hands and feet
• headache
• itching
• flushing
• nasal congestion
• redness
• skin burning sensation
• tingling or burning where the gel is applied
• warm skin sensation

Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not check with your doctor or seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

• eyelid swelling
• headache
• rash
• skin disease or discomfort
• worsening of rosacea

Stop taking the medication and seek immediate medical attention if any of the following occur:

• allergic reaction (e.g., rash, itchiness, redness, swelling, difficulty breathing)
• severe skin irritation

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking Onreltea (Brimonidine-topical).

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Each gram of white to light yellow opaque aqueous gel contains 5 mg of brimonidine tartrate equivalent to 3.3 mg of brimonidine free base. Nonmedicinal ingredients: carbomer, glycerol, methylparahydroxybenzoate, phenoxyethanol, propylene glycol, purified water, titanium dioxide and sodium hydroxide.

Do not use Onreltea (Brimonidine-topical) if you are allergic to brimonidine or any ingredients of the medication.

Do not give Onreltea (Brimonidine-topical) to children less than 2 years of age.

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There may be an interaction between brimonidine topical gel and any of the following:

If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

• stop taking one of the medications,
• change one of the medications to another,
• change how you are taking one or both of the medications, or
• leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with this medication. Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the Nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.

Before you begin using a medication, be sure to inform your doctor of any medical conditions or Allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication.

Cardiovascular effects: The cardiovascular system (heart and blood vessels) may be affected by the use of brimonidine. When brimonidine causes the blood vessels in the skin to narrow, it can also have this effect on other blood vessels in the body. If you have a history of Heart Attack, Angina, Stroke or other conditions that can be worsened if the blood supply is reduced, discuss with your doctor how Onreltea (Brimonidine-topical) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.

Kidney function: The kidneys are responsible for removing brimonidine from the body. Although studies have not been done to show this, it is possible that Kidney Disease or reduced kidney function may cause this medication to build up in the body, causing side effects. If you have reduced kidney function or kidney disease, discuss with your doctor how Onreltea (Brimonidine-topical) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Onreltea (Brimonidine-topical), and whether any special monitoring is needed.

Liver function: Brimonidine is broken down by the liver so it may be removed from the body. Although studies have not been done to demonstrate how liver disease or reduced liver function affects brimonidine, it is possible that liver problems may cause Onreltea (Brimonidine-topical) to build up in the body, causing side effects. If you have liver problems, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Onreltea (Brimonidine-topical), and whether any special monitoring is needed. Your doctor may want to test your liver function regularly with blood tests while you are taking Onreltea (Brimonidine-topical).

Raynaud's phenomenon: People with Raynaud's phenomenon experience poor blood circulation to the extremities. Brimonidine may make the symptoms of Raynaud's worse. If you have Raynaud's phenomenon, discuss with your doctor how Onreltea (Brimonidine-topical) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Onreltea (Brimonidine-topical), and whether any special monitoring is needed.

Pregnancy: Onreltea (Brimonidine-topical) should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking Onreltea (Brimonidine-topical), contact your doctor immediately.

Breast-feeding: It is not known if brimonidine passes into breast milk. If you are a breast-feeding mother and are taking Onreltea (Brimonidine-topical), it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.

Children: The safety and effectiveness of using Onreltea (Brimonidine-topical) have not been established for children. Onreltea (Brimonidine-topical) is not recommended for children between 2 and 18 years of age.

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