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Nitro Dur

Nitro Dur

(nitroglycerin)

Nitro Dur (Nitroglycerin) belongs to the class of medications called antianginals. Nitro Dur (Nitroglycerin) patches are used alone or in combination with other medications to prevent Angina attacks (chest pain).

Available form

Dosage

Patch

0.2MG/HR, 0.4MG/HR, 0.6MG/HR, 0.8MG/HR

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Nitro Dur information

Dosage

Side Effects

Available Form

Contraindications

Precautions

Warnings

The usual dose of Nitro Dur (Nitroglycerin) patches varies according to need. The patch is usually applied in the morning and taken off 12 to 14 hours later (leaving 10 to 12 hours overnight without the patch).

The patch may be applied to any convenient skin area – recommended sites include the upper arm, back, shoulders, or chest. Use a different application site each time. A suitable area may be shaved if necessary. Do not apply the patch to the ends of the arms or legs. Wash your hands thoroughly after application. Following use, discard the patch in a manner that prevents accidental application or ingestion by curious pets or children.

Many things can affect the dose of a medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are using the medication without consulting your doctor.

It is important to use Nitro Dur (Nitroglycerin) exactly as prescribed by your doctor. If you miss a dose, apply a patch as soon as possible and continue with your regular schedule. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not apply a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

Store Nitro Dur (Nitroglycerin) at room temperature and keep it out of the reach of children.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.

The side effects listed below are not experienced by everyone who takes Nitro Dur (Nitroglycerin). If you are concerned about side effects, discuss the risks and benefits of Nitro Dur (Nitroglycerin) with your doctor.

The following side effects have been reported by at least 1% of people taking Nitro Dur (Nitroglycerin). Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

dizziness or lightheadedness, especially when getting up from a sitting or lying down position
flushing of the face and neck
headache
nausea
reddened skin, rash, or itching where the patch was applied
vomiting

Although most of these side effects listed below don't happen very often, they could lead to serious problems if you do not seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

fast, slow, or irregular heartbeat
headache (severe or prolonged)

Stop taking the medication and seek immediate medical attention if any of the following occur:

signs of signs of a serious allergic reaction (e.g., abdominal cramps, difficulty breathing, nausea and vomiting, or swelling of the face and throat)
signs of a Heart Attack (e.g., chest pain or pressure, pain extending through shoulder and arm, nausea and vomiting, sweating)
signs of methemoglobinemia (e.g., shortness of breath; blue to purplish lips, fingers or toes; severe headache; fatigue; dizziness or loss of consciousness)

Contact a doctor at once if any of the following signs of overdose occur:

bluish-coloured lips, fingernails, or palms of the hands
convulsions (seizures)
dizziness (extreme) or fainting
feeling of extreme pressure in the head
Fever
shortness of breath
unusual tiredness or weakness
weak and fast heartbeat

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking Nitro Dur (Nitroglycerin).

There may be an interaction between Nitro Dur (Nitroglycerin) and any of the following:

alcohol
Aldesleukin
Aliskiren
alpha-agonists (e.g., Clonidine, methyldopa)
alpha-blockers (e.g., Alfuzosin, Doxazosin, Tamsulosin)
amifostine
Amiodarone
angiotensin converting enzyme inhibitors (ACEIs; Captopril, Enalapril, Ramipril)
angiotensin receptor blockers (ARBs; e.g., Candesartan, Irbesartan, Losartan)
second generation anti-psychotics (e.g., Clozapine, Olanzapine, Quetiapine, Risperidone)
barbiturates (e.g., butalbital, pentobarbital, Phenobarbital)
beta-adrenergic blockers (e.g., Atenolol, Propranolol, Sotalol)
brimonidine
Bromocriptine
Cabergoline
calcium channel blockers (e.g., Amlodipine, Diltiazem, Nifedipine, Verapamil)
clonidine
conivaptan
Dapsone
diazoxide
Dipyridamole
diuretics (water pills; e.g., Furosemide, Hydrochlorothiazide, triamterene)
Duloxetine
Eplerenone
ergot alkaloids (e.g., Dihydroergotamine, ergonovine, ergotamine, methylergonovine)
Heparin
Hydralazine
Guanfacine
levodopa
Minoxidil
other nitrates (e.g., Nitro Dur (Nitroglycerin), isosorbide dinitrate, isosorbide mononitrate)
Obinutuzumab
Pentoxifylline
phosphodiesterase 5 inhibitors (e.g., sildenafil, tadalafil, vardenafil)
prilocaine
riociguat
Ropinirole
Rosiglitazone
Selegiline
sodium nitrite
tetracaine
Tizanidine
tolcapone

If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

stop taking one of the medications,
change one of the medications to another,
change how you are taking one or both of the medications, or
leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with Nitro Dur (Nitroglycerin). Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the Nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.

Before you begin using a medication, be sure to inform your doctor of any medical conditions or Allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use Nitro Dur (Nitroglycerin).

Acute angina attacks: Nitro Dur (Nitroglycerin) patches are not intended for immediate relief of acute attacks of angina. Sublingual (under the tongue) Nitro Dur (Nitroglycerin) preparations (spray or tablets) should be used for this purpose.

Dizziness/reduced alertness: People using Nitro Dur (Nitroglycerin) may experience faintness or dizziness and reduced reaction time when driving or operating machinery, especially at the start of treatment. Avoid these and other hazardous tasks until you have determined how Nitro Dur (Nitroglycerin) affects you.

Heart disease: The benefits and safety of using the Nitro Dur (Nitroglycerin) patch have not been established for people who have had an acute heart attack or have Congestive Heart Failure.

Low blood pressure: Headaches or symptoms of low blood pressure such as weakness or dizziness, particularly when getting up suddenly from a sitting or lying down position, may result from taking too much Nitro Dur (Nitroglycerin). If these symptoms occur, your doctor may reduce the dose or have you stop using the Nitro Dur (Nitroglycerin) patch. People who might be negatively affected by low blood pressure should use Nitro Dur (Nitroglycerin) with caution. If you take diuretics or have preexisting low blood pressure, you may be at an increased risk of experiencing this effect.

Symptom changes: If your symptoms of angina increase at any time (including during the period of the day that you aren't taking the medication), be sure to tell your doctor.

Tolerance: People who use Nitro Dur (Nitroglycerin) may develop tolerance to the medication, resulting in it not working as well. Tolerance to other nitrates or nitrites can also happen, especially if a medication-free period is not observed each day. As tolerance to Nitro Dur (Nitroglycerin) patches develops, the effect of fast-acting sublingual (under the tongue) Nitro Dur (Nitroglycerin) is also somewhat reduced.

Pregnancy: Nitro Dur (Nitroglycerin) has not been studied for use by pregnant women and should not be used during pregnancy unless the benefits outweigh the risks. Be sure to tell your doctor if you are pregnant or planning to become pregnant. If you become pregnant while using Nitro Dur (Nitroglycerin), inform your doctor as soon as possible.

Breast-feeding: It is not known if Nitro Dur (Nitroglycerin) passes into breast milk. If you are a breast-feeding mother and are taking Nitro Dur (Nitroglycerin), it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.

Children: The safety and effectiveness of Nitro Dur (Nitroglycerin) for children have not been established.

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All material © 1996-2024 MediResource Inc. Terms and conditions of use. The contents herein are for informational purposes only. Always seek the advice of your physician or other qualified health providers with any questions you may have regarding a medical condition.

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