Invega Trinza
(paliperidone)
Invega Trinza (Paliperidone) belongs to the class of medications called antipsychotics. It is used to control the symptoms of Schizophrenia and related psychotic disorders.
Available form
Dosage
Injectable Syringe, Long-Acting
50MG/0.5ML, 75MG/0.75ML, 100MG/1ML, 150MG/1.5ML, 175MG/0.875M, 350MG/1.75ML, 525MG/2.625M
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Invega Trinza information
After the monthly dose of Invega Trinza (Paliperidone) injection has been established for at least 4 months, using Invega Trinza (Paliperidone) injectable suspension, and the same dose has been given for at least 2 consecutive months, your doctor may suggest changing to a long-lasting form of intramuscular injection.
The dose of Invega Trinza (Paliperidone) prolonged-release injectable suspension is calculated based on the monthly dose of injectable suspension that works best for you. The first dose of prolonged-release injection is given at the doctor's appointment when you would otherwise receive a monthly injection. It is injected intramuscularly at your doctor's office every 3 months. Under exceptional circumstances, a dose may be given 2 weeks before or 2 weeks after the scheduled 3 month dose.
Many things can affect the dose of a medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.
It is important to take Invega Trinza (Paliperidone) exactly as prescribed by your doctor. If you miss an appointment to receive a Invega Trinza (Paliperidone) prolonged-release injection, contact your doctor as soon as possible to reschedule your appointment. Store Invega Trinza (Paliperidone) at room temperature, protect it from moisture, and keep it out of the reach of children.
Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.
Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.
The side effects listed below are not experienced by everyone who takes Invega Trinza (Paliperidone). If you are concerned about side effects, discuss the risks and benefits of Invega Trinza (Paliperidone) with your doctor.
The following side effects have been reported by at least 1% of people taking Invega Trinza (Paliperidone). Many of these side effects can be managed, and some may go away on their own over time.
Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.
- anxiety
- blurred vision
- breast swelling and sexual difficulties (men)
- Diarrhea
- dizziness
- drowsiness
- Dry Mouth
- fatigue
- flu-like symptoms (sudden lack of energy, Fever, cough, sore throat)
- headache
- increased appetite
- increased saliva production
- injection site pain, swelling, or irritation
- itching
- joint stiffness
- missed or irregular menstrual periods (women)
- muscle stiffness or spasm
- nasal congestion
- nausea
- nightmares
- restlessness
- sensations that the room is spinning
- skin rash
- slowness of movement
- stomach or abdominal pain
- tremor
- trouble sleeping
- vomiting
- weakness
- weight changes
Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not seek medical attention.
Check with your doctor as soon as possible if any of the following side effects occur:
- abnormal heart rhythms such as fast or slow heart rate
- abnormal movements of the face or tongue
- blood pressure changes
- changes in body temperature, or feeling very hot and unable to cool down
- Constipation (new or worsening)
- difficulty swallowing
- dizziness, especially when standing from a lying or seated position
- fainting
- inability to move or respond while awake
- leakage of milk from breasts (women)
- palpitations
- signs of Anemia (low red blood cells; e.g., dizziness, pale skin, unusual tiredness or weakness, shortness of breath)
- signs of a blood clot in the arm or leg (tenderness, pain, swelling, warmth, or redness in the arm or leg) or lungs (difficulty breathing, sharp chest pain that is worse when breathing in, coughing, coughing up blood, sweating, or passing out)
- signs of clotting problems (e.g., unusual nosebleeds, bruising, blood in urine, coughing blood, bleeding gums, cuts that don't stop bleeding)
- signs of Depression (e.g., poor concentration, changes in weight, changes in sleep, decreased interest in activities, thoughts of suicide)
- signs of infection (symptoms may include fever or chills, severe diarrhea, shortness of breath, prolonged dizziness, headache, stiff neck, weight loss, or listlessness)
- signs of liver problems (e.g., nausea, vomiting, diarrhea, loss of appetite, weight loss, yellowing of the skin or whites of the eyes, dark urine, pale stools)
- symptoms of mania (e.g., decreased need for sleep, elevated or irritable mood, racing thoughts)
- skin rash
- symptoms of high blood sugar (e.g., frequent urination, increased thirst, excessive eating, unexplained weight loss, poor wound healing, infections, fruity breath odour)
- symptoms of low blood sugar (e.g., cold sweat, cool pale skin, headache, fast heartbeat, weakness)
- symptoms of a urinary tract infection (e.g., pain when urinating; urinating more often than usual; low back or flank pain; uncontrollable movement of the face, eyes, or body)
- vaginal discharge
- vision changes
Stop taking the medication and seek immediate medical attention if any of the following occur:
- complications of uncontrolled Diabetes (e.g., shortness of breath, confusion, and loss of consciousness)
- muscle pain or achiness combined with very dark-coloured urine
- prolonged, continuous erection (an erection that lasts more than 4 hours)
- seizures
- signs of neuroleptic malignant syndrome (e.g., confusion, reduced consciousness, high fever, or muscle stiffness)
- signs of pancreatitis (e.g., abdominal pain on the upper left side, back pain, nausea, fever, chills, rapid heartbeat, swollen abdomen)
- signs of severe skin reactions (e.g., blistering, peeling, a rash covering a large area of the body, a rash that spreads quickly, or a rash combined with fever or discomfort)
- sudden changes in mental state
- symptoms of a Anaphylaxis (severe allergic reaction) (e.g., itching; skin rash; shortness of breath; swelling of the face, lips, or tongue)
- symptoms of a Stroke (e.g., sudden weakness or numbness of the face, arms, or legs – especially on one side; slurred speech; vision problems)
Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking Invega Trinza (Paliperidone).
175 mg/0.875 mL
Each prefilled syringe containing a white-to-off-white, sterile, aqueous, prolonged-release suspension contains 175 mg of Invega Trinza (Paliperidone) (as 273 mg of Invega Trinza (Paliperidone) palmitate). Nonmedicinal ingredients: citric acid monohydrate, polyethylene glycol 4000, polysorbate 20, sodium dihydrogen phosphate monohydrate, sodium hydroxide, and water for injection.
263 mg/1.315 mL
Each prefilled syringe containing a white-to-off-white, sterile, aqueous, prolonged-release suspension contains 263 mg of Invega Trinza (Paliperidone) (as 410 mg of Invega Trinza (Paliperidone) palmitate). Nonmedicinal ingredients: citric acid monohydrate, polyethylene glycol 4000, polysorbate 20, sodium dihydrogen phosphate monohydrate, sodium hydroxide, and water for injection.
350 mg/1.75 mL
Each prefilled syringe containing a white-to-off-white, sterile, aqueous, prolonged-release suspension contains 350 mg of Invega Trinza (Paliperidone) (as 546 mg of Invega Trinza (Paliperidone) palmitate). Nonmedicinal ingredients: citric acid monohydrate, polyethylene glycol 4000, polysorbate 20, sodium dihydrogen phosphate monohydrate, sodium hydroxide, and water for injection.
525 mg/2.625 mL
Each prefilled syringe containing a white-to-off-white, sterile, aqueous, prolonged-release suspension contains 525 mg of Invega Trinza (Paliperidone) (as 819 mg of Invega Trinza (Paliperidone) palmitate). Nonmedicinal ingredients: citric acid monohydrate, polyethylene glycol 4000, polysorbate 20, sodium dihydrogen phosphate monohydrate, sodium hydroxide, and water for injection.
Do not take Invega Trinza (Paliperidone) if you:
- are allergic to Invega Trinza (Paliperidone) or any ingredients of the medication
- are allergic to Risperidone
There may be an interaction between Invega Trinza (Paliperidone) and any of the following:
- alcohol
- Aldesleukin
- Aliskiren
- alpha-agonists (e.g., Clonidine, methyldopa)
- alpha-blockers (e.g., Alfuzosin, Doxazosin, Silodosin, Tamsulosin)
- amantadine
- amiodarone
- amphetamines (e.g., Dextroamphetamine, Lisdexamfetamine)
- angiotensin converting enzyme inhibitors (ACEIs; Captopril, Ramipril)
- angiotensin receptor blockers (ARBs; e.g., Candesartan, Irbesartan, Losartan)
- antihistamines (e.g., cetirizine, doxylamine, Diphenhydramine, Hydroxyzine, Loratadine)
- Apalutamide
- azelastine
- "azole" antifungals (e.g., itraconazole, ketoconazole, Voriconazole)
- barbiturates (e.g., butalbital, Phenobarbital)
- benzodiazepines (e.g., Alprazolam, Diazepam, Lorazepam)
- beta-adrenergic blockers (e.g., Atenolol, Propranolol, sotalol)
- brimonidine
- Buprenorphine
- Bupropion
- Buspirone
- calcium channel blockers (e.g., Amlodipine, Diltiazem, Nifedipine, Verapamil)
- cannabis
- chloral hydrate
- Cyclosporine
- diabetes medications (e.g., chlorpropamide, Glyburide, insulin, Metformin, Rosiglitazone)
- Disopyramide
- diuretics (water pills; e.g., Furosemide, Hydrochlorothiazide, Indapamide, triamterene)
- dofetilide
- Donepezil
- dopamine agonists (Parkinson's disease medications; e.g., Apomorphine, Bromocriptine, levodopa, Pramipexole, Ropinirole, Rotigotine)
- Dronedarone
- efavirenz
- Eliglustat
- Galantamine
- general anaesthetics (medications to put you to sleep for surgery)
- grapefruit juice
- Hepatitis C antivirals (e.g., glecaprevir, ledipasvir, ombitasvir, paritaprevir, velpatasvir)
- Hydralazine
- hydroxychloroquine
- kava kava
- Lapatinib
- lithium
- Loperamide
- lumacaftor and Ivacaftor
- macrolide antibiotics (e.g., azithromycin, clarithromycin, erythromycin)
- Methadone
- Methylphenidate
- Metoclopramide
- monoamine oxidase inhibitors (M.O.S. e.g., Moclobemide, Phenelzine, Rasagiline, Selegiline, Tranylcypromine)
- muscle relaxants (e.g., Baclofen, Cyclobenzaprine, methocarbamol, orphenadrine)
- Nabilone
- narcotic pain relievers (e.g., Codeine, Fentanyl, Morphine, Oxycodone)
- Obinutuzumab
- other antipsychotics (e.g., chlorpromazine, Clozapine, Haloperidol, Olanzapine, Pimozide, Quetiapine, risperidone)
- procainamide
- Propafenone
- quinidine
- quinine
- quinolone antibiotics (e.g., ciprofloxacin, moxifloxacin)
- rifampin
- ritonavir
- Rivastigmine
- St. John's wort
- seizure medications (e.g., Carbamazepine, Gabapentin, Levetiracetam, Perampanel, Phenytoin, Topiramate)
- selective serotonin reuptake inhibitors (SSRIs; e.g., Citalopram, Fluoxetine, Paroxetine, Sertraline)
- serotonin-norepinephrine reuptake inhibitors (SNRIs; e.g., Desvenlafaxine, Duloxetine, Venlafaxine)
- sodium oxybate
- suvorexant
- Tapentadol
- Tetrabenazine
- thalidomide
- tolcapone
- Tramadol
- Trazodone
- tricyclic antidepressants (e.g., Amitriptyline, Clomipramine, Desipramine, Trimipramine)
- Tryptophan
- Zolpidem
- Zopiclone
If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:
- stop taking one of the medications,
- change one of the medications to another,
- change how you are taking one or both of the medications, or
- leave everything as is.
An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.
Medications other than those listed above may interact with Invega Trinza (Paliperidone). Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the Nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.
Before you begin using a medication, be sure to inform your doctor of any medical conditions or Allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use Invega Trinza (Paliperidone).
Abnormal heart rhythms: Invega Trinza (Paliperidone) can cause abnormal heart rhythms. Certain medications (e.g., quinidine, procainamide, Amiodarone, Sotalol, Chlorpromazine, thioridazine, moxifloxacin) can increase the risk of a type of abnormal heart rhythm called QT prolongation and should not be used in combination with Invega Trinza (Paliperidone). People who have a slow heart rate, low potassium or magnesium levels, or have congenital prolongation of the QT interval are more at risk for this type of abnormal heart rhythm and its complications. Talk to your doctor about the risks and benefits of using Invega Trinza (Paliperidone).
Blood Clots: Rarely, Invega Trinza (Paliperidone) increases the chance of blood clot formation, causing reduction of blood flow to organs or the extremities.
If you have a history of clotting, you may be at increased risk of experiencing blood clot-related problems such as Heart Attack, stroke, or clots in the deep veins of your leg. Discuss with your doctor how Invega Trinza (Paliperidone) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Invega Trinza (Paliperidone), and whether any special monitoring is needed.
Blood counts: Invega Trinza (Paliperidone) can decrease the number of neutrophils (a type of white blood cell that helps fight infection), red blood cells (which carry oxygen), and platelets (which help your blood to clot). Your doctor will do blood tests to monitor this. If you notice any signs of infection (e.g., fever, chills, or sore throat) or unusual bleeding or bruising, contact your doctor immediately.
Body temperature: Invega Trinza (Paliperidone), like other antipsychotic medications, can disrupt the body's ability to control body temperature. People who exercise vigorously, who are exposed to extreme heat, are dehydrated, or are taking anticholinergic medications (e.g., Benztropine, Oxybutynin) are more at risk. Contact your doctor as soon as possible if you feel very hot and are unable to cool down while taking Invega Trinza (Paliperidone).
Cataract surgery: During eye surgery for Cataracts, people who take or have taken Invega Trinza (Paliperidone) are at risk for developing a condition called Intraoperative Floppy Iris Syndrome (IFIS). This condition can lead to eye damage. If you are planning to have an operation on your eye, inform your doctor if you are taking or have taken Invega Trinza (Paliperidone).
Cholesterol: Invega Trinza (Paliperidone) can cause increased blood cholesterol levels. If you are at risk of developing High Cholesterol or you have high cholesterol levels before starting Invega Trinza (Paliperidone), discuss with your doctor how Invega Trinza (Paliperidone) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Invega Trinza (Paliperidone), and whether any special monitoring is needed.
Diabetes and blood sugar: Invega Trinza (Paliperidone) may cause an increase in blood sugar levels and glucose tolerance may change. People with diabetes may find it necessary to monitor their blood sugar more frequently while using Invega Trinza (Paliperidone).
If you have diabetes or are at risk for developing diabetes, discuss with your doctor how Invega Trinza (Paliperidone) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Invega Trinza (Paliperidone), and whether any special monitoring is needed.
If you experience weakness, increased thirst, increased urination, and increased appetite while taking Invega Trinza (Paliperidone), contact your doctor.
Drowsiness/reduced alertness: Invega Trinza (Paliperidone) may affect the mental or physical abilities needed to drive or operate machinery. Avoid driving, operating machinery, or performing other hazardous tasks until you have determined how Invega Trinza (Paliperidone) affects you.
Gastrointestinal problems: Invega Trinza (Paliperidone) should not be taken by people with conditions associated with narrowing of the gastrointestinal tract (e.g., esophagus disorders, inflammatory bowel disease, "short gut" syndrome, Cystic Fibrosis), or by people who have difficulty swallowing.
Heart conditions: If you have a heart condition, such as Angina, heart failure, irregular heartbeat, or you have had a heart attack, discuss with your doctor how Invega Trinza (Paliperidone) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Invega Trinza (Paliperidone), and whether any special monitoring is needed.
Hypersensitivity syndrome: A severe allergic reaction called hypersensitivity syndrome has occurred for some people taking medications similar to Invega Trinza (Paliperidone). Stop taking the medication and get immediate medical attention if you have symptoms of a severe allergic reaction, including fever, severe rash, swollen glands, yellowing of the skin or eyes, or flu-like symptoms with skin rash or blistering.
Lactose intolerance: Certain strengths (3 mg tablets) of Invega Trinza (Paliperidone) tablets are prepared with lactose. If you have hereditary lactose or galactose intolerance problems you should not take this strength of the medication.
Kidney function: Kidney Disease or reduced kidney function may cause Invega Trinza (Paliperidone) to build up in the body, causing side effects. If you have reduced kidney function or kidney disease, discuss with your doctor how Invega Trinza (Paliperidone) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Invega Trinza (Paliperidone), and whether any special monitoring is needed.
Low Blood Pressure: Invega Trinza (Paliperidone) may cause low blood pressure when rising from a sitting or lying down position. If you feel dizzy, lightheaded, or feel your pulse racing, call your doctor. While you are taking Invega Trinza (Paliperidone), get up slowly after you have been sitting or lying down for a prolonged period.
Neuroleptic malignant syndrome (NMS): Invega Trinza (Paliperidone), like other antipsychotic medications, can cause a potentially fatal syndrome known as NMS. If you experience the symptoms of NMS, such as high fever, muscle stiffness, confusion or loss of consciousness, sweating, racing or irregular heartbeat, and fainting, get immediate medical attention.
Parkinson's Disease: People with Parkinson's disease or Dementia with Lewy bodies (DLB) may be at an increased risk of NMS (see warning about NMS), as well as other side effects associated with Invega Trinza (Paliperidone). Talk to your doctor about the risks and benefits of using Invega Trinza (Paliperidone).
Risperidone: People who are taking risperidone should not take Invega Trinza (Paliperidone) at the same time. These medications are related, and taking them together may cause an increased risk of side effects.
Seizures: Invega Trinza (Paliperidone) may increase the risk of seizures, especially in people who have had seizures in the past. People who are at risk of seizures who take Invega Trinza (Paliperidone) should be closely monitored by their doctor. If you have had seizures, discuss with your doctor how Invega Trinza (Paliperidone) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Invega Trinza (Paliperidone), and whether any special monitoring is needed.
Suicidal or agitated behaviour: People taking Invega Trinza (Paliperidone) may feel agitated (restless, anxious, aggressive, emotional, and feeling not like themselves), or they may want to hurt themselves or others. These symptoms may occur within several weeks after starting Invega Trinza (Paliperidone). If you experience these side effects or notice them in a family member who is taking Invega Trinza (Paliperidone), contact your doctor immediately. You should be closely monitored by your doctor for emotional and behaviour changes while taking Invega Trinza (Paliperidone).
Tardive dyskinesia (TD): TD, a syndrome consisting of potentially irreversible, involuntary, repetitive movements of the face and tongue muscles, may develop in people who take certain antipsychotic medications including Invega Trinza (Paliperidone). Although TD appears most commonly in seniors, especially women, it is impossible to predict who will develop TD. The risk of developing TD increases with higher doses and long-term treatment. If you experience muscle twitching or abnormal movements of the face or tongue, contact your doctor as soon as possible.
Pregnancy: Invega Trinza (Paliperidone) should not be used during pregnancy unless the benefits outweigh the risks. Using Invega Trinza (Paliperidone) during the last three months of pregnancy can harm the developing baby and cause withdrawal symptoms after birth. If you become pregnant while taking Invega Trinza (Paliperidone), contact your doctor immediately.
Breast-feeding: Invega Trinza (Paliperidone) passes into breast milk. If you are a breast-feeding mother and are taking Invega Trinza (Paliperidone), it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.
Children: The safety and effectiveness of using Invega Trinza (Paliperidone) have not been established for children under 18 years of age. Clinical studies using Invega Trinza (Paliperidone) to treat adolescents with schizophrenia have shown an increased likelihood of movement disorders occurring in this group.
Seniors: Medications similar to Invega Trinza (Paliperidone) can increase the risk of death as a result of a stroke, mini-stroke, and severe infection, when used to treat seniors with dementia. Invega Trinza (Paliperidone) should not be used to treat seniors with dementia.
All material © 1996-2024 MediResource Inc. Terms and conditions of use. The contents herein are for informational purposes only. Always seek the advice of your physician or other qualified health providers with any questions you may have regarding a medical condition.
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