Before you begin using a medication, be sure to inform your doctor of any medical conditions or Allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use Ozempic (Semaglutide).

Diabetes identification: It is important to either wear a bracelet (or necklace) or carry a card indicating you have diabetes and are taking medication to manage your blood glucose levels.

Heart problems: Ozempic (Semaglutide) may increase heart rate and may affect how electrical impulses travel through the heart muscle. If you have heart disease or an abnormal heart rhythm (e.g., heart block or fast heart rate), discuss with your doctor how Ozempic (Semaglutide) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Ozempic (Semaglutide), and whether any special monitoring is needed.

Kidney function: Ozempic (Semaglutide) may cause decreased kidney function, kidney failure or worsening chronic kidney failure. If you have reduced kidney function or Kidney Disease, discuss with your doctor how Ozempic (Semaglutide) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Ozempic (Semaglutide), and whether any special monitoring is needed.

Low blood glucose (hypoglycemia): People who use Ozempic (Semaglutide) and are also taking a sulfonylurea (e.g., glyburide, Gliclazide) or insulin to control high blood sugar are more at risk of experiencing hypoglycemia (low blood sugar). If you experience symptoms of hypoglycemia such as a cold sweat, nervousness or shakiness, fast heartbeat, headache, hunger, confusion, lightheadedness, weakness, and numbness or tingling of the tongue or lips, contact your doctor. Your doctor may need to adjust the dose of your medication(s).

Pancreatitis (inflammation of the pancreas): Ozempic (Semaglutide) can cause pancreatitis. If you experience symptoms of pancreatitis such as severe and persistent abdominal pain that may move to the back with or without vomiting, contact your doctor immediately. If you have previously had pancreatitis, discuss with your doctor how Ozempic (Semaglutide) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Ozempic (Semaglutide), and whether any special monitoring is needed.

Risk of thyroid cancer: In rare cases, people have developed thyroid cancer while using medications similar to Ozempic (Semaglutide). People with a personal or family history of thyroid cancer or people who have multiple endocrine neoplasia syndrome type 2 (a disease where people have tumours in more than one gland in their body) should not use Ozempic (Semaglutide). If you develop difficulty swallowing or breathing, hoarseness or notice a mass developing in your neck, contact your doctor as soon as possible.

Pregnancy: Ozempic (Semaglutide) should not be used during pregnancy. If you become pregnant while using Ozempic (Semaglutide), contact your doctor immediately.

Breast-feeding: It is not known if Ozempic (Semaglutide) passes into breast milk. If you are a breast-feeding mother and are taking Ozempic (Semaglutide), it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.

Children: The safety and effectiveness of using Ozempic (Semaglutide) have not been established for children.

Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use Contrave.

Accidental ingestion: If you are dependent on narcotics and you ingest Contrave, you could experience severe symptoms of withdrawal including confusion, nausea, shakiness, sweating, anxiety, visual hallucinations, vomiting, or diarrhea. Avoid taking narcotic medications while you are taking naltrexone-bupropion.

Diabetes: Weight loss often causes decreased blood glucose. As a result, using naltrexone-bupropion may cause episodes of low blood sugar when taken by people with diabetes who are taking certain oral medications to control blood sugar. You may find it necessary to monitor your blood sugar more frequently while using Contrave.

If you have diabetes or are at risk for developing diabetes, discuss with your doctor how Contrave may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Contrave, and whether any special monitoring is needed.

Drowsiness/reduced alertness: Bupropion may affect the mental or physical abilities needed to drive or operate machinery. Avoid driving, operating machinery, or performing other hazardous tasks until you have determined how Contrave affects you.

Heart disease: Bupropion can increase blood pressure and heart rate. It is not known whether it is safe for use by people with a recent history of Heart Attack or unstable heart disease. If you have had a heart attack within the past 6 months, have an irregular heartbeat, high blood pressure, Congestive Heart Failure or a recent Stroke, discuss with your doctor how Contrave may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Contrave, and whether any special monitoring is needed.

Galactose intolerance/glucose malabsorption: Contrave contains lactose. If you have lactose or galactose intolerance you should not take Contrave.

Glaucoma: Contrave may cause the symptoms of glaucoma (increased pressure in the eye) to become worse. If you have glaucoma, discuss with your doctor how Contrave may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Contrave, and whether any special monitoring is needed. Report any changes in vision to your doctor as soon as possible while you are taking Contrave.

Identical medications: Wellbutrin®, Zyban® and several other medications contain bupropion. Revia® and Relistor® contain naltrexone. If you are taking naltrexone-bupropion, do not take any other product containing bupropion or naltrexone, as the risk of side effects increases with an increased dosage.

Interference with opiate-containing mediations: Because Contrave works by blocking the effects of opiates, it will reduce the effectiveness of narcotic pain relievers. It may also interfere with other medications that contain opiates such as certain cough and cold medications, antidiarrheal medications, and some analgesics (pain medications). Trying to overcome the blocking effects of naltrexone by taking larger doses of narcotics may result in severe side effects of the narcotic. Talk to your doctor or pharmacist about non-opiate containing alternatives.

Kidney function:  Kidney Disease or reduced kidney function may cause Contrave to build up in the body, causing side effects. If you have kidney problems, discuss with your doctor how Contrave may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Contrave, and whether any special monitoring is needed. Contrave is not recommended for people with end-stage kidney disease.

Liver function: Liver disease or reduced liver function may cause Contrave to build up in the body, causing side effects. If you have liver problems, discuss with your doctor how Contrave may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Contrave, and whether any special monitoring is needed. Naltrexone-bupropion is not recommended for people with severely decreased liver function.

Naltrexone-bupropion has been reported to cause decreased liver function. If you experience symptoms of liver problems such as fatigue, feeling unwell, loss of appetite, nausea, yellowing of the skin or whites of the eyes, dark urine, pale stools, abdominal pain or swelling, and itchy skin, contact your doctor immediately.

Lupus: There may be an association between taking naltrexone – bupropion and the autoimmune conditions systemic lupus erythematosus (SLE) and cutaneous lupus erythematosus (CLE). If you develop any skin rash (particularly on the face), fatigue, joint pain, or swelling, contact your doctor as soon as possible.

Mental health: Bupropion may trigger mania and make behaviour and thought disturbances worse for people who have mental health conditions. It may also cause symptoms of psychosis and mania to develop for people who have not had these symptoms before. If you experience symptoms such as hallucinations, mania (feeling unusually over-excited or uninhibited), or delusional thinking, or notice them in a family member who is taking Contrave, contact your doctor as soon as possible. If you have mental health concerns, discuss with your doctor how Contrave may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Contrave, and whether any special monitoring is needed.

Seizure risk: Bupropion may increase the risk of seizures. If you are at risk of seizures, discuss with your doctor how Contrave may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Contrave, and whether any special monitoring is needed.

Things that increase the risk of seizures include:

• addiction to cocaine, stimulants, or opiates (such as morphine)
• diabetes treated with oral medications or insulin
• excessive alcohol use
• history of head trauma or seizures (including Epilepsy)
• severe liver problems
• tumours of the brain or spinal cord
• use of other medications that make seizures more likely (e.g., antipsychotics, antidepressants, lithium, theophylline, steroids)
• use of over-the-counter stimulants or appetite suppressants

Serotonin toxicity: Severe reactions are possible when naltrexone - bupropion is combined with other medications that act on serotonin, such as tricyclic antidepressants and serotonin reuptake inhibitors, medications used to treat depression. Symptoms of a reaction may include muscle rigidity and spasms, difficulty moving, and changes in mental state including delirium and agitation. Coma and death are possible.

Suicidal or agitated behaviour, or other behaviour changes: People taking Contrave may feel agitated (restless, anxious, aggressive, emotional, and feeling not like themselves), or they may want to hurt themselves or others. These symptoms may occur within several weeks after people start taking Contrave. If you experience these side effects or notice them in a family member who is taking Contrave, contact your doctor immediately. Your doctor will monitor you for emotional and behavioural changes while you are taking bupropion.

Pregnancy: Weight loss does not benefit a woman during pregnancy and may cause harm to the developing baby. Use of either of these medications may also cause harm to the developing baby. For these reasons, Contrave should not be used during pregnancy. If you become pregnant while taking Contrave, contact your doctor immediately.

Breast-feeding: Both naltrexone and bupropion pass into breast milk. If you are breast-feeding and are taking Contrave, it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.

Children: The safety and effectiveness of using Contrave have not been established for children.

Seniors: Seniors may be at an increased risk of side effects due to age-related decreased kidney or liver function.