Before you begin taking a medication, be sure to inform your doctor of any medical conditions or Allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should take Celsentri.
Blood pressure: Maraviroc may cause dizziness and a drop in blood pressure when rising from a sitting or lying down position, especially if you are taking medications that lower blood pressure. Get up slowly from a sitting or lying down position while you are taking Celsentri. If you faint while taking Celsentri, contact your doctor.
Dizziness: If you experience dizziness while taking maraviroc, do not drive or operate heavy machinery until you are no longer experiencing this side effect.
Heart disease: Maraviroc may increase the risk of heart attack or chest pain, particularly for people who have a history of heart problems. If you have a history of heart disease or are at risk for heart disease, discuss with your doctor how Celsentri may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Celsentri, and whether any special monitoring is needed.
Hepatitis B or C: If you have hepatitis B or C, discuss with your doctor how Celsentri may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Celsentri, and whether any special monitoring is needed.
If you experience symptoms of liver problems (itchy rash, yellowing of the eyes or skin, dark urine, vomiting, upper right abdominal pain), stop taking maraviroc and contact your doctor immediately. Continue taking maraviroc and see your doctor immediately if you experience nausea, fever, flu-like symptoms, or fatigue.
Hypersensitivity reactions: A severe allergic reaction called hypersensitivity syndrome has occurred for some people with the use of maraviroc. Stop taking the medication and get immediate medical attention if you have symptoms of a severe allergic reaction, including fever, swollen glands, yellowing of the skin or eyes, or flu-like symptoms with skin rash or blistering.
Immune reconstitution inflammatory syndrome: A condition called immune reconstitution inflammatory syndrome can occur when you start taking HIV medications such as maraviroc. Your immune system may get stronger and start to fight other infections that have been hidden in your body (e.g., pneumonia, herpes, or Tuberculosis). Contact your doctor if you develop any new symptoms after starting HIV medications such as maraviroc.
Infections: People taking maraviroc can experience an increase in infections, most commonly, upper respiratory tract infections. If you experience increased symptoms such as cough, sinus congestion, or sore throat, speak with your doctor.
Kidney function: The safety and effectiveness of maraviroc have not been established for people with reduced kidney function. If you have reduced kidney function or Kidney Disease, discuss with your doctor how Celsentri may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Celsentri, and whether any special monitoring is needed.
Liver function: Liver disease or reduced liver function may cause maraviroc to build up in the body, causing side effects. Maraviroc may also cause liver failure or a decrease in liver function. If you experience symptoms of liver problems (itchy rash, yellowing of the eyes or skin, dark urine, vomiting, upper right abdominal pain), stop taking maraviroc and contact your doctor immediately. Continue taking maraviroc and see your doctor immediately if you experience nausea, fever, flu-like symptoms, or fatigue.
If you have reduced liver function or liver disease, discuss with your doctor how Celsentri may affect your medical condition. Your doctor will monitor your liver function closely while you are taking Celsentri.
Pregnancy: Celsentri should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking Celsentri, contact your doctor immediately.
Breast-feeding: It is not known if maraviroc passes into breast milk. However, breast-feeding is not recommended for HIV-positive women since the virus can be passed through breast-milk.
Children: The safety and effectiveness of using Celsentri have not been established for children less than 18 years of age.
