Zomig Rapimelt (Zolmitriptan) belongs to a class of medications known as 5-hydroxytryptamine agonists (also called "triptans"). It is used to treat migraine Headaches with or without aura (warning signs that occur prior to the onset of a migraine headache). The pain of migraine headaches is thought to be caused by dilated blood vessels inside the head. Zomig Rapimelt (Zolmitriptan) relieves migraine headaches by constricting these blood vessels.

Zomig Rapimelt (Zolmitriptan) is not recommended for other types of headache or for headache prevention. In most people, Zomig Rapimelt (Zolmitriptan) eliminates or reduces the symptoms of migraines including headache, nausea, vomiting, and sensitivity to light and sound.

Zomig Rapimelt (Zolmitriptan) may be available under multiple brand names and/or in several different forms. Any specific brand name of Zomig Rapimelt (Zolmitriptan) may not be available in all of the forms or approved for all of the conditions discussed here. As well, some forms of Zomig Rapimelt (Zolmitriptan) may not be used for all of the conditions discussed here.

Your doctor may have suggested Zomig Rapimelt (Zolmitriptan) for conditions other than those listed in these drug information articles. If you have not discussed this with your doctor or are not sure why you are taking Zomig Rapimelt (Zolmitriptan), speak to your doctor. Do not stop taking Zomig Rapimelt (Zolmitriptan) without consulting your doctor.

Do not give Zomig Rapimelt (Zolmitriptan) to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take Zomig Rapimelt (Zolmitriptan) if their doctor has not prescribed it.

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The recommended adult dose is a single dose of 2.5 mg. If the migraine headache returns, the dose may be repeated after 2 hours. You should not take a total dose of more than 10 mg in any 24-hour period. If a dose has not helped your headache at all, do not take a second dose without first consulting a doctor.

Zomig Rapimelt (Zolmitriptan) tablets should be taken whole with water at the first sign of a migraine headache, but they can be taken at any time during a migraine headache. You may also split the tablets in half if your doctor has recommended that you do this to get a lower dose.

Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.

It is important to use Zomig Rapimelt (Zolmitriptan) exactly as prescribed by your doctor.

Store Zomig Rapimelt (Zolmitriptan) at room temperature, protect it from moisture, and keep it out of the reach of children.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.

The side effects listed below are not experienced by everyone who takes Zomig Rapimelt (Zolmitriptan). If you are concerned about side effects, discuss the risks and benefits of Zomig Rapimelt (Zolmitriptan) with your doctor.

The following side effects have been reported by at least 1% of people taking Zomig Rapimelt (Zolmitriptan). Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

• changed sense of taste (nasal spray only)
• discomfort inside the nose
• dizziness
• drowsiness
• Dry Mouth
• feeling sick
• muscle aches
• nosebleeds (nasal spray only)
• stomach pain
• unusual tiredness or muscle weakness
• vomiting

Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

• fast, pounding, or irregular heartbeat
• increased blood pressure
• increased urine production or need to urinate
• trouble swallowing

Stop taking the medication and seek immediate medical attention if any of the following occur:

• convulsions (seizures)
• heart attack (symptoms include pain, pressure, tightness, or heaviness in the chest, jaw, neck, or shoulder; sweating; or shortness of breath)
• sensations of tingling, heat, heaviness or pressure, dizziness, tiredness, or feeling sick
• Anaphylaxis (severe allergic reaction) (symptoms include: swelling of the face or throat; Hives; difficulty breathing)
• stroke; symptoms include:
  • sudden confusion or problems with speech
  • sudden dizziness or loss of coordination
  • sudden numbness or weakness, especially on one side of the body
  • sudden severe headache, especially if it seems different from your usual headaches
  • sudden vision problems in one or both eyes
• sudden or severe abdominal pain, stomach pain, or bloody Diarrhea

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking Zomig Rapimelt (Zolmitriptan).

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Each orally dispersible, white, round, uncoated tablet, intagliated "Z" on one side with a bevelled-edged, contains Zomig Rapimelt (Zolmitriptan) 2.5 mg. Nonmedicinal ingredients: aspartame, citric acid, colloidal silicon dioxide, crospovidone, magnesium stearate, mannitol, microcrystalline cellulose, orange flavour, and sodium bicarbonate.

Do not use Zomig Rapimelt (Zolmitriptan) if you:

• are allergic to Zomig Rapimelt (Zolmitriptan) or any ingredients of the medication
• are taking monoamine oxidase (MAO) inhibitors (e.g., Phenelzine, Tranylcypromine) or have taken them within the past 2 weeks
• do not have a clear diagnosis of migraine
• have Angina (chest pain), including Prinzmetal's angina (coronary vasospasm)
• have blood vessel disease (e.g., ischemic bowel disease, Raynaud's syndrome, Stroke, transient ischemic attacks [TIAs])
• have certain types of migraine headaches (including hemiplegic, basilar, or ophthalmoplegic migraine)
• have had a Heart Attack
• have heart disease (e.g., heart valve disease, ischemic heart disease, abnormal heart rhythms, congenital heart disease)
• have severe or uncontrolled high blood pressure
• have taken another 5-hydroxytryptamine agonist (i.e., Naratriptan, Sumatriptan, Rizatriptan) in the previous 24 hours
• have taken ergotamine-containing or ergot-type medications (such as Dihydroergotamine, ergotamine, or methysergide) in the previous 24 hours

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There may be an interaction between Zomig Rapimelt (Zolmitriptan) and any of the following:

• antipsychotics (e.g., Chlorpromazine, Clozapine, Haloperidol, Olanzapine, Quetiapine, Risperidone)
• Bromocriptine
• Buspirone
• Cimetidine
• ergot-containing medications (e.g., dihydroergotamine, ergotamine, or methysergide) if taken at the same time or within the previous 24 hours
• lithium
• Mirtazapine
• monoamine oxidase inhibitors (M.O.S. e.g., Moclobemide, Rasagiline, Selegiline, tranylcypromine) if taken at the same time or within 14 days of taking Zomig Rapimelt (Zolmitriptan)
• Propranolol
• St. John's wort
• serotonin antagonists (antiemetic medications; e.g., Granisetron, Ondansetron)
• serotonin/norepinephrine reuptake inhibitors (SNRIs; e.g., Desvenlafaxine, Duloxetine, Venlafaxine)
• selective serotonin reuptake inhibitors (SSRIs; e.g., Citalopram, Fluoxetine, Paroxetine, Sertraline)
• Tramadol
• Trazodone
• tricyclic antidepressants (e.g., Amitriptyline, Clomipramine, Desipramine, Trimipramine)
• other "triptans" (5-hydroxytryptamine agonists) (e.g., naratriptan, rizatriptan, sumatriptan) if taken at the same time or within the previous 24 hours
• Tryptophan

If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

• stop taking one of the medications,
• change one of the medications to another,
• change how you are taking one or both of the medications, or
• leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with Zomig Rapimelt (Zolmitriptan). Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the Nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.

Before you begin taking a medication, be sure to inform your doctor of any medical conditions or Allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should take Zomig Rapimelt (Zolmitriptan).

Allergic reactions: Rare, severe allergic reactions to Zomig Rapimelt (Zolmitriptan) may occur. Because of the possibility of allergic reaction, you should not use Zomig Rapimelt (Zolmitriptan) if you are allergic to any of the other medications of this class (5-hydroxytryptamine agonists).

Blood pressure: Zomig Rapimelt (Zolmitriptan) may cause an increase in blood pressure. If you have severe or uncontrolled high blood pressure you should not take Zomig Rapimelt (Zolmitriptan).

Drowsiness/reduced alertness: You may feel drowsy as a result of taking Zomig Rapimelt (Zolmitriptan). Do not perform tasks requiring alertness (e.g., driving or operating machinery) if you experience drowsiness or dizziness.

Galactose intolerance/glucose malabsorption:  Zomig Rapimelt (Zolmitriptan) tablets are prepared with lactose. If you have lactose or galactose intolerance, you should not take the tablet formulation.

Heart disease: Zomig Rapimelt (Zolmitriptan) may cause narrowing of the blood vessels that supply the heart. This can lead to chest pain, heart attacks, and other heart problems. For this reason, you should not use Zomig Rapimelt (Zolmitriptan) if you have heart or blood vessel disease. If you have certain risk factors for heart disease (e.g., high blood pressure, High Cholesterol, smoking, Obesity, Diabetes, family history of Coronary Artery Disease, Menopause, men over 40 years of age), tell your doctor.

Liver function:  Liver disease or reduced liver function may cause Zomig Rapimelt (Zolmitriptan) to build up in the body, causing side effects. If you have liver problems, discuss with your doctor how Zomig Rapimelt (Zolmitriptan) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Zomig Rapimelt (Zolmitriptan), and whether any special monitoring is needed. Your doctor may want to test your liver function regularly with blood tests while you are taking Zomig Rapimelt (Zolmitriptan). You may need a lower dose of Zomig Rapimelt (Zolmitriptan).

Medication overuse headaches: As with other pain relief medications, overuse of Zomig Rapimelt (Zolmitriptan) may lead to medication overuse headaches, or "rebound headaches" where the headache returns as the medication wears off. Avoid taking more of Zomig Rapimelt (Zolmitriptan) than is recommended by your doctor. If you experience more frequent headaches, contact your doctor as soon as possible.

Seizures: There have been rare reports of seizures experienced by people taking Zomig Rapimelt (Zolmitriptan). If you have a history of Epilepsy or other conditions that increase the risk for seizure your doctor should closely monitor you while taking Zomig Rapimelt (Zolmitriptan).

Serotonin syndrome: Severe reactions are possible when Zomig Rapimelt (Zolmitriptan) is combined with other medications that act on serotonin, such as tricyclic antidepressants and serotonin reuptake inhibitors – medications used to treat Depression. These combinations must be avoided. Symptoms of a reaction may include muscle rigidity and spasms, difficulty moving, and changes in mental state including delirium and agitation. Coma and death are possible.

If you are taking antidepressants, discuss with your doctor how Zomig Rapimelt (Zolmitriptan) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Zomig Rapimelt (Zolmitriptan), and whether any special monitoring is needed.

Pregnancy: Zomig Rapimelt (Zolmitriptan) should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking Zomig Rapimelt (Zolmitriptan), contact your doctor immediately.

Breast-feeding: It is not known if Zomig Rapimelt (Zolmitriptan) passes into breast milk. If you are a breast-feeding mother and are taking Zomig Rapimelt (Zolmitriptan), it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.

Children and adolescents: The safety and effectiveness of using Zomig Rapimelt (Zolmitriptan) have not been established for children or adolescents.

Seniors: The use of Zomig Rapimelt (Zolmitriptan) by people over the age of 65 years is not recommended.

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