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Amerge

Amerge

(naratriptan)

Amerge (Naratriptan) belongs to a class of medications known as 5-hydroxytryptamine agonists. It is used to treat migraine attacks with or without aura (warning signs that occur prior to the onset of a migraine).

Available form

Dosage

Tablet

1MG, 2.5MG

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Amerge information

Dosage

Side Effects

Available Form

Contraindications

Precautions

Warnings

The recommended adult single dose of Amerge (Naratriptan) ranges from 1 mg to 2.5 mg. The maximum recommended single dose is 2.5 mg.

Amerge (Naratriptan) should be taken as early as possible after the onset of a migraine headache, but is effective if taken at a later stage. A second tablet may be taken if the headache returns, but not sooner than 4 hours after the first tablet was taken. You should not take any more than 5 mg of Amerge (Naratriptan) in any 24-hour period (i.e., 2 of the 2.5 mg strength or 5 of the 1 mg strength).

If you do not get relief from the first dose of Amerge (Naratriptan), a second dose should not be taken for the same attack unless you talk with your doctor first, as it is unlikely to be of benefit.

Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.

The tablets should be swallowed whole with fluids.

It is important to take Amerge (Naratriptan) exactly as prescribed. The safety of treating more than 4 migraines with Amerge (Naratriptan) in a 1-month period of time is not known. If you are experiencing more than 4 migraines in a month, contact your doctor.

Store Amerge (Naratriptan) at room temperature, protect it from light and keep it out of the reach of children.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.

The side effects listed below are not experienced by everyone who takes Amerge (Naratriptan). If you are concerned about side effects, discuss the risks and benefits of Amerge (Naratriptan) with your doctor.

The following side effects have been reported by at least 1% of people taking Amerge (Naratriptan). Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

acid reflux
changed sense of taste
Constipation
Diarrhea
dizziness
drowsiness
Dry Mouth
ear, nose, or throat infections
feeling unwell
flushing
headache
increased sensitivity to sun
itching
muscle cramps
muscle or joint pain
nasal congestion
nausea
skin rash
stomach discomfort or pain
sweating
thirst
trouble sleeping
vomiting

Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

anxiety
decreased coordination
eye problems (e.g., dry eyes, blurred vision)
increased sensitivity to touch
irregular heartbeat (e.g., fast or slow heart rate, pounding heartbeat)
numbness and tingling of head and face
symptoms of Low Blood Pressure (e.g., fainting, dizziness, lightheadedness, blurred vision, increased thirst, nausea)
symptoms of a urinary tract infection (e.g. pain when urinating, urinating more often than usual, low back or flank pain)
trembling or shaking of hands or feet
trouble thinking clearly

Stop taking the medication and seek immediate medical attention if any of the following occur:

convulsions (seizures)
sensation of cold, numbness, or purplish discolouration in hands or feet
severe, sudden abdominal pain
severe chest pain
signs of a blood clot in blood vessel (e.g., sudden vision change or dizziness, chest pain, pain and swelling in one leg muscle)
signs of a heart attack (e.g., chest pain or pressure, pain extending through shoulder and arm, nausea and vomiting, sweating, tightness, heaviness or pressure in the arm, chest, jaw, or neck)
signs of a serious allergic reaction (e.g., abdominal cramps, difficulty breathing, nausea and vomiting, or swelling of the face and throat)
signs of a stroke (e.g., sudden vision change, dizziness, difficulty speaking or moving, rapid onset of severe headache)

There may be an interaction between Amerge (Naratriptan) and any of the following:

amphetamines (e.g., Dextroamphetamine, Lisdexamfetamine)
antipsychotics (e.g., Chlorpromazine, Fluphenazine, Haloperidol, Pimozide, Quetiapine, Risperidone)
Bromocriptine
Buspirone
Cabergoline
Dextromethorphan
ergot-containing medications (e.g., dihydroergotamine, ergotamine, or methysergide) if taken at the same time or within the previous 24 hours
lithium
Meperidine
Metoclopramide
Mirtazapine
monoamine oxidase inhibitors (M.O.S. e.g., Moclobemide, Rasagiline, Selegiline, Tranylcypromine) if taken at the same time or within 14 days of Amerge (Naratriptan)

nefazodone
other 5-hydroxytryptamine agonists (e.g., rizatriptan, sumatriptan, zolmitriptan)
SAMe
selective norepinephrine reuptake inhibitors (SNRIs; e.g., Venlafaxine)
selective serotonin receptor agonists (SSRIs; e.g., Fluoxetine, Fluvoxamine, Paroxetine, Sertraline)
St. John's wort
Tapentadol
Tramadol
Trazodone
tricyclic antidepressant drugs (e.g., Amitriptyline, Imipramine)
Tryptophan

If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

stop taking one of the medications,
change one of the medications to another,
change how you are taking one or both of the medications, or
leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with Amerge (Naratriptan). Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the Nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.

Before you begin using a medication, be sure to inform your doctor of any medical conditions or Allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use Amerge (Naratriptan).

Allergic reactions: If you are allergic to sulfonamides you may experience an allergic reaction to Amerge (Naratriptan). Reactions range from skin allergy to serious allergic reaction. Rarely, anaphylactic reactions to Amerge (Naratriptan) may occur. Because of the possibility of allergic reactions, people who are allergic to any of the other drugs of this class (5-hydroxytryptamine agonists) should not use Amerge (Naratriptan).

Blood pressure: Amerge (Naratriptan) may cause increases in blood pressure. If you have mild to moderately increased blood pressure, discuss with your doctor how Amerge (Naratriptan) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Amerge (Naratriptan), and whether any special monitoring is needed.

People with severe or uncontrolled high blood pressure should not take Amerge (Naratriptan).

Drowsiness/reduced alertness: Amerge (Naratriptan) may cause drowsiness. Do not drive, operate machinery, or perform other potentially hazardous tasks until you have determined how Amerge (Naratriptan) affects you.

Headache type: Amerge (Naratriptan) should only be used where there is a clear diagnosis of migraine headache.

Heart disease: There have been rare reports of heart attack and stroke occurring with people who have appeared to be otherwise healthy. If you have risk factors for heart disease, discuss with your doctor how Amerge (Naratriptan) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Amerge (Naratriptan), and whether any special monitoring is needed.

Risk factors for heart disease include high blood pressure, High Cholesterol levels, smoking, Obesity, Diabetes, a family history of heart disease, being male over 40 years old, or being a post-menopausal woman.

If you have heart disease you should not use Amerge (Naratriptan).

Kidney function: For people with reduced kidney function, it takes longer for Amerge (Naratriptan) to leave the body, which may result in an increase in side effects. If you have reduced kidney function or Kidney Disease, discuss with your doctor how Amerge (Naratriptan) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Amerge (Naratriptan), and whether any special monitoring is needed.

If you have severely reduced kidney function you should not use Amerge (Naratriptan).

Liver function: For people with reduced liver function, it takes longer for Amerge (Naratriptan) to leave the body, which may result in an increase in side effects. If you have reduced liver function or liver disease, discuss with your doctor how Amerge (Naratriptan) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Amerge (Naratriptan), and whether any special monitoring is needed.

If you have severely reduced liver function you should not use Amerge (Naratriptan).

Medication overuse headache: As with other medications for treating headaches, the overuse of Amerge (Naratriptan) may create a situation where the headache returns as the medication wears off, prompting the use of more medication. Do not take more Amerge (Naratriptan) than recommended by your doctor. If you require more than 5 mg of Amerge (Naratriptan) in a 24 hour period, or need to treat more than four headaches over 30 days, contact your doctor.

Medications containing ergotamine: After taking any ergotamine-containing preparation, wait at least 24 hours before taking Amerge (Naratriptan). Likewise, ergotamine-containing preparations should not be taken for at least 24 hours following Amerge (Naratriptan) administration.

Seizures: There have been rare reports of seizures occurring with Amerge (Naratriptan). If you have a history of Epilepsy or medical conditions that increase the risk of seizures, discuss with your doctor how Amerge (Naratriptan) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Amerge (Naratriptan), and whether any special monitoring is needed.

Serotonin syndrome: Severe reactions are possible when Amerge (Naratriptan) is combined with other medications that act on serotonin such as tricyclic antidepressants and serotonin reuptake inhibitors, medications used to treat Depression. These combinations must be avoided. Symptoms of a reaction may include muscle rigidity and spasms, difficulty moving, changes in mental state including delirium and agitation. Coma and death are possible.

If you are taking antidepressants, discuss with your doctor how Amerge (Naratriptan) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Amerge (Naratriptan), and whether any special monitoring is needed.

Pregnancy: Amerge (Naratriptan) should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking Amerge (Naratriptan), contact your doctor immediately.

Breast-feeding: It is not known if Amerge (Naratriptan) passes into breast milk. If you are a breast-feeding mother and are taking Amerge (Naratriptan), it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.

Children: The safety and effectiveness of using Amerge (Naratriptan) have not been established for children, and its use by this age group is not recommended.

Seniors: There may be a higher risk of side effects such as high blood pressure and heart problems associated with the use of Amerge (Naratriptan) by people over the age of 65 years. The use of Amerge (Naratriptan) by people in this age group is not recommended.

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All material © 1996-2024 MediResource Inc. Terms and conditions of use. The contents herein are for informational purposes only. Always seek the advice of your physician or other qualified health providers with any questions you may have regarding a medical condition.

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