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Zavesca

Zavesca

(miglustat)

Zavesca (Miglustat) is a glucosylceramide synthase inhibitor. It is used treat mild-to-moderate cases of a rare genetic disease known as type I Gaucher disease, where there is a buildup of glucosylceramide in the body's immune system.

Available form

Dosage

Capsule

100MG

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Zavesca information

Dosage

Side Effects

Available Form

Contraindications

Precautions

Warnings

For type I Gaucher disease, the recommended adult dose is 100 mg taken by mouth, 3 times daily at regular intervals.

For Niemann-Pick type C disease, the recommended dose for people over 12 years of age is 200 mg taken by mouth 3 times daily. The children's dose is based on body weight.

Zavesca (Miglustat) should be swallowed whole with a glass of water. It may be taken with or without food.

Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.

It is important to take Zavesca (Miglustat) exactly as prescribed by your doctor. If you miss a dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

Store Zavesca (Miglustat) at room temperature, protect it from moisture, and keep it out of the reach of children.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

Before you begin using a medication, be sure to inform your doctor of any medical conditions or Allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use Zavesca (Miglustat).

Bleeding: Zavesca (Miglustat) may cause a reduced number of platelets in the blood, which can make it difficult to stop cuts from bleeding. If you notice any signs of bleeding, such as frequent nosebleeds, unexplained bruising, or black and tarry stools, notify your doctor as soon as possible.

Diarrhea: Diarrhea is a very common side effect of Zavesca (Miglustat). If you experience diarrhea, taking Zavesca (Miglustat) between meals may help. If the diarrhea is bothersome, contact your doctor.

Dizziness/reduced alertness: Zavesca (Miglustat) commonly causes dizziness. Avoid driving or operating machinery until you know how Zavesca (Miglustat) affects you.

Kidney Disease: Zavesca (Miglustat) is removed from the body by the kidneys and its elimination may be reduced in people with kidney disease. If you have kidney disease, discuss with your doctor how Zavesca (Miglustat) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Zavesca (Miglustat), and whether any special monitoring is needed.

Severe Gaucher disease: The safety and effectiveness of Zavesca (Miglustat) have not been evaluated for people with severe Gaucher disease. Zavesca (Miglustat) is used for mild-to-moderate type 1 Gaucher disease.

Pregnancy: Zavesca (Miglustat) should not be used by women during pregnancy as it may cause harm to the unborn baby. Both men and women should use a reliable method of contraception. Men should not father a child while they are taking Zavesca (Miglustat) and for 3 months after stopping the medication. If you become pregnant while you are taking Zavesca (Miglustat), contact your doctor immediately.

Breast-feeding: It is not known if Zavesca (Miglustat) passes into breast milk. If you are a breast-feeding mother and are taking Zavesca (Miglustat), it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.

Children: The safety and effectiveness of using Zavesca (Miglustat) for type I Gaucher disease have not been established for children under 18 years of age. The safety and effectiveness of using Zavesca (Miglustat) for Niemann-Pick type C disease have not been established for children under 4 years of age.

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