Apo Naproxen
(naproxen)
Naproxen belongs to the group of medications called nonsteroidal anti-inflammatory drugs (NSAIDs). It is used to treat the symptoms of Rheumatoid Arthritis, osteoarthritis, ankylosing spondylitis, and juvenile rheumatoid arthritis.
Available form
Dosage
Tablet
250MG, 375MG, 500MG
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Apo Naproxen information
The use of naproxen should be limited to the lowest possible dose for the shortest length of treatment.
The recommended adult dose of naproxen tablets for osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis ranges from 250 mg to 500 mg twice daily. Take naproxen with food or milk. The suppository form of naproxen is usually used once daily to replace one of the oral doses.
If you are maintained on a dose of 750 mg or 1,000 mg daily, the long-acting (sustained-release) form of the medication may be substituted for the immediate-release form. In many cases, this will allow the medication to be taken only once daily. The sustained-release form of the medication should be swallowed whole.
The dose of naproxen for children treated for juvenile rheumatoid arthritis is based on body weight. The recommended dose is given in 2 divided doses every 12 hours. Naproxen suspension is often used for young children who have difficulty swallowing tablets. Shake the suspension gently before using.
Use an oral syringe to measure each dose of the liquid, as it gives a more accurate measurement than household teaspoons. Naproxen should not be given to children under the age of 2 years, as the safety and effectiveness of the medication for this age group have not been established.
When used to treat pain or muscle and skeletal injuries, the usual recommended adult dose of naproxen is 250 mg 2 or 3 times daily or 375 mg 2 times daily.
For treatment of menstrual pain and cramps, the recommended first dose is 500 mg followed by 250 mg every 6 to 8 hours as needed. No more than 1,250 mg should be taken in one day. Alternatively, one 500 mg tablet may be taken twice daily as recommended by your doctor.
Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.
It is important to use Apo Naproxen exactly as prescribed by your doctor. If you miss a dose, use it as soon as possible and continue with your regular schedule. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not use a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.
Store Apo Naproxen at room temperature, protect it from light and moisture, and keep it out of the reach of children.
Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.
Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.
The side effects listed below are not experienced by everyone who takes Apo Naproxen. If you are concerned about side effects, discuss the risks and benefits of Apo Naproxen with your doctor.
The following side effects have been reported by at least 1% of people taking Apo Naproxen. Many of these side effects can be managed, and some may go away on their own over time.
Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.
- abdominal or stomach cramps, pain, or discomfort (mild to moderate)
- drowsiness
- headache (mild to moderate)
- heartburn or indigestion
- itchy skin
- nausea
- vomiting
Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not seek medical attention.
Check with your doctor as soon as possible if any of the following side effects occur:
- bleeding from rectum (with suppositories)
- difficulty hearing
- dizziness or lightheadedness
- heartburn (persistent)
- increased sensitivity to light
- rectal irritation (with suppositories)
- ringing or buzzing sound in the ears
- signs of Anemia (low red blood cells; e.g., dizziness, pale skin, unusual tiredness or weakness, shortness of breath)
- signs of clotting problems (e.g., unusual nosebleeds, bruising, blood in urine, coughing blood, bleeding gums, cuts that don't stop bleeding)
- signs of liver problems (e.g., nausea, vomiting, Diarrhea, loss of appetite, weight loss, yellowing of the skin or whites of the eyes, dark urine, pale stools)
- signs of Meningitis not caused by infection (e.g., severe headache, throbbing, or with stiff neck or back)
- swelling of feet, lower legs, arms, and hands
- unusual tiredness or weakness without any other symptoms
- urinating problems (e.g., bladder pain, painful urination, frequent urination, red or brown urine)
- weight gain
Stop taking the medication and seek immediate medical attention if any of the following occur:
- blurred vision or any visual disturbance
- signs of bleeding in the stomach (e.g., bloody, black, or tarry stools, spitting up of blood, vomiting blood or material that looks like coffee grounds)
- shortness of breath, wheezing, and chest tightness
- symptoms of a Anaphylaxis (severe allergic reaction) (e.g., Hives; difficulty breathing; swelling of the face, mouth, throat, or tongue)
Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking Apo Naproxen.
Enteric-coated tablets
250 mg
Each white, round, biconvex, enteric-coated tablet engraved "APO" on one side and "250" on the other contains 250 mg of naproxen. Nonmedicinal ingredients: methylcellulose, croscarmellose sodium, magnesium stearate, colloidal silicon dioxide, hydroxyethyl cellulose, polyethylene glycol, titanium dioxide, triethyl citrate, talc, and methacrylic acid copolymer.
375 mg
Each white, capsule-shaped, biconvex, enteric-coated tablet engraved "APO" on one side and "375" on the other contains 375 mg of naproxen. Nonmedicinal ingredients: methylcellulose, croscarmellose sodium, magnesium stearate, colloidal silicon dioxide, hydroxyethyl cellulose, polyethylene glycol, titanium dioxide, triethyl citrate, talc, and methacrylic acid copolymer.
500 mg
Each white, capsule- shaped, biconvex, enteric-coated tablet engraved "APO" on one side and "500" on the other contains 500 mg of naproxen. Nonmedicinal ingredients: methylcellulose, croscarmellose sodium, magnesium stearate, colloidal silicon dioxide, hydroxyethyl cellulose, polyethylene glycol, titanium dioxide, triethyl citrate, talc, and methacrylic acid copolymer.
Tablets
125 mg
Each pale green, oval, biconvex tablet engraved "APO-125" on one side contains 125 mg of naproxen. Nonmedicinal ingredients: methylcellulose, croscarmellose sodium, magnesium stearate, colloidal silicon dioxide, D&C Yellow No. 10, and FD&C Blue No. 2.
250 mg
Each yellow, oval, biconvex tablet engraved "APO-250" on one side contains 250 mg of naproxen. Nonmedicinal ingredients: methylcellulose, croscarmellose sodium, magnesium stearate, colloidal silicon dioxide, D&C Yellow No. 10, and FD&C Yellow No. 6.
375 mg
Each peach-coloured, capsule-shaped, biconvex tablet scored and engraved "APO 375" on one side contains 375 mg of naproxen. Nonmedicinal ingredients: methylcellulose, croscarmellose sodium, magnesium stearate, colloidal silicon dioxide, and FD&C Yellow No. 6.
500 mg
Each yellow, capsule-shaped, biconvex tablet scored and engraved "APO 500" on one side contains 500 mg of naproxen. Nonmedicinal ingredients: methylcellulose, croscarmellose sodium, magnesium stearate, colloidal silicon dioxide, D&C Yellow No. 10 and FD&C Yellow No. 6.
Do not use Apo Naproxen if you:
- are allergic to naproxen or any ingredients of Apo Naproxen
- are allergic to Asa or other NSAIDs (e.g., Ibuprofen, Ketorolac, Diclofenac) or have had allergic symptoms (e.g., runny nose, Asthma, itchy skin rash, nasal polyps, swelling of the face, throat, or tongue) caused by these medications
- are breast-feeding
- are in the third trimester (last 3 months) of pregnancy
- have a bleeding disorder
- have an inflammatory bowel disease (e.g., Ulcerative Colitis, Crohn's Disease)
- have an ulcer or bleeding in the stomach or intestines
- have bleeding in the brain
- have had recent or are going to have heart bypass surgery
- have high blood potassium
- have liver disease or severely reduced liver function
- have severely reduced or worsening kidney function
- have uncontrolled heart failure
Do not give naproxen suspension to children less than 2 years of age.
Do not use the suppository form of Apo Naproxen if you:
- have any inflammatory lesions of the rectum or anus
- have recently had rectal or anal bleeding
Do not give the suppository or tablet form of Apo Naproxen to children under 18 years of age.
There may be an interaction between naproxen and any of the following:
- 5-ASA medications (e.g., Mesalamine, olsalzine, Sulfasalazine)
- acetylsalicylic acid (ASA)
- alcohol
- Aliskiren
- aminoglycoside antibiotics (e.g., Amikacin, gentamicin, tobramycin)
- angiotensin-converting enzyme (ACE) inhibitors (e.g., enalapril, ramipril)
- angiotensin receptor blockers (e.g., candesartan, Losartan, Telmisartan)
- Apixaban
- beta-blockers (e.g., atenolol, metoprolol)
- bisphosphonates (e.g., Alendronate, etidronate)
- Celecoxib
- Cholestyramine
- clopidogrel
- Colestipol
- corticosteroids (e.g., cortisone, prednisone)
- cyclosporine
- dabigatran
- Dasatinib
- Deferasirox
- deoxycholic acid
- Desmopressin
- Digoxin
- diuretics (water pills; e.g., Furosemide, hydrochlorothiazide, triamterene)
- heparin
- herbal products that affect blood clotting (e.g., cat's claw, chamomile, fenugreek, evening primrose, feverfew, garlic, ginger, ginseng, turmeric)
- Hydralazine
- lithium
- low-molecular-weight heparins (e.g., Dalteparin, Enoxaparin, Tinzaparin)
- Methotrexate
- other non-steroidal anti-inflammatory drugs (NSAIDs e.g., diclofenac, ibuprofen, ketorolac)
- Obinutuzumab
- omega-3 fatty acids
- Pemetrexed
- potassium supplements
- Prasugrel
- prostaglandin eye drops (e.g., Latanoprost, Bimatoprost)
- quinolone antibiotics (e.g., ciprofloxacin, Norfloxacin, Ofloxacin)
- Rivaroxaban
- selective serotonin reuptake inhibitors (SSRIs; e.g., citalopram, fluoxetine, sertraline)
- serotonin-norepinephrine reuptake inhibitors (SNRIs; Desvenlafaxine, Duloxetine, Venlafaxine)
- sodium phosphates
- Tacrolimus
- Ticagrelor
- Ticlopidine
- tenofovir
- tricyclic antidepressants (e.g., Amitriptyline, Clomipramine, Desipramine, Trimipramine)
- vancomycin
- vitamin E
- warfarin
If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:
- stop taking one of the medications,
- change one of the medications to another,
- change how you are taking one or both of the medications, or
- leave everything as is.
An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.
Medications other than those listed above may interact with Apo Naproxen. Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications that you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the Nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.
Before you begin using a medication, be sure to inform your doctor of any medical conditions or Allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use Apo Naproxen.
HEALTH CANADA ADVISORY
June 8, 2021
Health Canada has issued new information concerning the use of non-steroidal anti-inflammatory drugs (NSAIDs). To read the full Health Canada Advisory, visit Health Canada's web site at www.hc-sc.gc.ca.
Allergic reactions: If you have had a reaction to acetylsalicylic acid (ASA) or other NSAIDs (e.g., ibuprofen, Ketoprofen, ketorolac) that included a runny nose, itchy skin rash, nasal polyps, or shortness of breath and wheezing, you should not take Apo Naproxen. If you experience symptoms of a severe allergic reaction (e.g., hives; difficulty breathing; wheezing; swelling of the face, tongue, or throat), get immediate medical attention.
Anemia: Naproxen may cause low levels of red blood cells. If you experience symptoms of reduced red blood cell count (anemia) such as shortness of breath, feeling unusually tired or pale skin, contact your doctor as soon as possible.
Aseptic meningitis: Apo Naproxen can rarely cause symptoms of aseptic meningitis (inflammation or swelling of the membranes around the brain and spinal cord that is not caused by bacteria). If you have an autoimmune condition (e.g., systemic Lupus erythematosus, mixed connective tissue disease), you are more at risk for developing this. If you experience symptoms such as stiff neck, severe headache, nausea, vomiting, Fever, or changes in consciousness, stop taking Apo Naproxen can get immediate medical attention.
Bladder problems: Apo Naproxen may cause bladder pain, painful or difficult urination, or increased frequency of urination. If these symptoms occur without an explanation (e.g., infection), stop taking Apo Naproxen and contact your doctor.
Blood clotting: Apo Naproxen may reduce the ability of the blood to clot. If you are taking anticoagulants (e.g., Warfarin, Heparin) or have Hemophilia or other blood disorders (e.g., low platelets), discuss with your doctor how Apo Naproxen may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Apo Naproxen, and whether any special monitoring is needed. If you have a bleeding disorder, do not take Apo Naproxen.
Drowsiness/reduced alertness: Do not drive a car or perform hazardous tasks until you determine that Apo Naproxen does not impair your ability to perform these tasks safely.
Fluid and electrolyte balance: NSAIDs such as naproxen can cause fluid retention and edema (swelling). This can lead to high blood pressure or worsening of heart failure. If you have heart failure or high blood pressure, discuss with your doctor how Apo Naproxen may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Apo Naproxen, and whether any special monitoring is needed. If you have severe, uncontrolled heart failure, you should not take Apo Naproxen.
Naproxen may also cause high blood potassium levels. If you are a senior; have Diabetes or kidney failure; or are taking beta-blockers (e.g., Metoprolol, Atenolol), angiotensin converting enzyme (ACE) inhibitors (e.g., Ramipril, Enalapril), or some diuretics (e.g., triamterene, Amiloride), you are more at risk of high blood potassium. If you have high blood potassium levels, you should not take Apo Naproxen.
Heart Attack and Stroke: Apo Naproxen may be associated with an increased risk of heart attack or stroke. The risk is higher with larger total daily doses and longer treatment periods. If you have a history of heart disease (e.g., heart attack, stroke, heart failure) or have risk factors for heart disease (e.g., high blood pressure, High Cholesterol, diabetes, smoking, Kidney Disease) discuss with your doctor how Apo Naproxen may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Apo Naproxen, and whether any special monitoring is needed.
Kidney function: Long-term use of naproxen may lead to a higher risk of reduced kidney function. If you have kidney disease, liver disease, or heart failure; take diuretics (water pills); or are a senior, you have an increased risk for kidney problems while taking Apo Naproxen. If you are taking medications such as diuretics (e.g., Hydrochlorothiazide, triamterene, Indapamide), ACE inhibitors (e.g., enalapril, ramipril), angiotensin receptor blockers (e.g., Valsartan, Candesartan), or Cyclosporine, you are also at an increased risk.
If you have these conditions or are taking these medications, discuss with your doctor how Apo Naproxen may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Apo Naproxen, and whether any special monitoring is needed. If you have severe kidney problems, you should not take Apo Naproxen.
Liver function: Rarely, Apo Naproxen causes liver problems. If you have reduced liver function, discuss with your doctor how Apo Naproxen may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Apo Naproxen, and whether any special monitoring is needed.
If you experience unexplained tiredness, loss of appetite, itchy skin or yellowing of the skin or eyes while taking Apo Naproxen, contact your doctor immediately. If you have liver disease or severely reduced liver function, you should not take Apo Naproxen.
Skin reactions: Apo Naproxen can cause skin reactions, some of which may be severe. If you experience a skin rash, especially where the skin is blistering or peeling, stop taking Apo Naproxen and contact your doctor.
Apo Naproxen may make your skin more sensitive to sunlight (including sunlamps) and may cause Sunburn; skin blisters; and skin redness, itching, or discolouration. If you have a reaction from the sun while taking Apo Naproxen, contact your doctor.
Ulcers or bleeding in the stomach or intestines: Naproxen can cause stomach ulcers, perforation (holes), and bleeding from the stomach. These complications can occur at any time without warning, and are sometimes severe enough to require immediate medical attention. The risk of ulcers and bleeding increase if you are taking higher doses of naproxen for longer periods of time.
Other factors that increase the risk of these complications include drinking excessive amounts of alcohol, increased age, smoking, poor health, H. pylori infection, and taking certain medications (e.g., warfarin, ASA, Clopidogrel, Prednisone, Citalopram, Fluoxetine, Paroxetine, Sertraline).
If you currently have ulcers in the stomach or intestines that are bleeding, or have an inflammatory bowel disease (e.g., Crohn's disease, ulcerative colitis), you should not take Apo Naproxen. If you have a history of these conditions, discuss with your doctor how Apo Naproxen may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Apo Naproxen, and whether any special monitoring is needed.
Stop taking the medication and get immediate medical attention if you experience symptoms or signs of stomach ulcers or bleeding in the stomach (black, tarry stools, blood in stools, stomach pain, vomiting blood or coffee-grind material). These reactions can occur at any time during treatment without warning.
Vision changes: Occasionally, naproxen is related to changes in vision. If you experience blurred or decreased vision while taking Apo Naproxen, contact your doctor.
Pregnancy: Apo Naproxen should not be used during pregnancy, especially during the third trimester. If you become pregnant while taking Apo Naproxen, contact your doctor immediately.
Apo Naproxen may reduce fertility. If you are trying to get pregnant or are having difficulty getting pregnant, you should not take Apo Naproxen.
Breast-feeding: Apo Naproxen is not recommended for women who are breast-feeding.
Children: The safety and effectiveness of naproxen suspension have not been established for children less than 2 years of age. Naproxen tablets or suppositories should not be used by children under 18 years of age, unless recommended by your doctor.Seniors: If you are a senior, you may have a higher risk of experiencing side effects from Apo Naproxen. You should use the lowest effective dose under close medical supervision.
All material © 1996-2024 MediResource Inc. Terms and conditions of use. The contents herein are for informational purposes only. Always seek the advice of your physician or other qualified health providers with any questions you may have regarding a medical condition.
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