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Isdn

Isdn

(isosorbide-dinitrate)

Isosorbide dinitrate belongs to the class of medications called anti-anginals. It is used to prevent chest pain associated with Angina.

Available form

Dosage

Tablet

10MG, 30MG

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Isdn information

Dosage

Side Effects

Available Form

Contraindications

Precautions

Warnings

Oral tablets: The recommended dose of isosorbide oral tablets for long-term prevention of angina is 5 mg to 30 mg taken 4 times daily, leaving a period of time called the nitrate-free period (as discussed with your doctor) where the body is relatively free of the medication. For example, the medication may be taken at 8 am, 12 pm, 4 pm, and 8 pm. This schedule allows the medication to keep working effectively as it prevents your body from getting too used to its effects.

Sublingual tablets (tablets dissolve in 20 seconds under the tongue): Isosorbide sublingual (under the tongue) tablets are dissolved under the tongue to prevent an angina attack. Dissolve 1 or 2 tablets (5 mg to 10 mg) under the tongue, between the cheek and gum, or between the lip and gum every 2 to 4 hours. An extra dose of 5 mg to 10 mg may be taken before stressful situations that are likely to cause an angina attack. Do not eat, drink, smoke, or chew tobacco while the tablet is dissolving. Talk to your doctor about the dose and nitrate-free period that are right for you.

Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.

It is important to take Isdn (Isosorbide-dinitrate) exactly as prescribed by the doctor. If you miss a dose, take it as soon as possible and continue with your regular schedule. If it is close to the time of your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

Store Isdn (Isosorbide-dinitrate) at room temperature, protect it from light and moisture, and keep it out of the reach of children.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

There may be an interaction between isosorbide dinitrate and any of the following:

Abiraterone acetate
alcohol
Aldesleukin
Aliskiren
alpha blockers (e.g., Alfuzosin, Doxazosin, Tamsulosin)
alpha agonists (e.g., Clonidine, methyldopa)
Amiodarone
angiotensin converting enzyme inhibitors (ACEIs; Captopril, Enalapril, Ramipril)
angiotensin receptor blockers (ARBs; e.g., candasartan, Irbesartan, Losartan)
second generation anti-psychotics (e.g., Clozapine, Olanzapine, Quetiapine, Risperidone)
Aprepitant
"azole" antifungals (e.g., itraconazole, ketoconazole, Voriconazole)
barbiturates (e.g., butalbital, pentobarbital Phenobarbital)
Bicalutamide
beta-adrenergic blockers (e.g., Atenolol, Propranolol, Sotalol)
boceprevir
Bosentan
brimonidine
calcium channel blockers (e.g., Amlodipine, Diltiazem, Nifedipine, Verapamil)
Carbamazepine
conivaptan
Crizotinib
Cyclosporine
Dabrafenib
Dapsone
Dasatinib
Deferasirox
Desipramine
Dexamethasone
diuretics (water pills; e.g., Furosemide, Hydrochlorothiazide, triamterene)
Dronedarone
Duloxetine
Enzalutamide
ergot alkaloids
grapefruit juice
Guanfacine
Haloperidol
HIV non-nucleoside reverse transcriptase inhibitors (NNRTIs; e.g., delavirdine, efavirenz, etravirine, nevirapine)
HIV protease inhibitors (e.g., atazanavir, indinavir, ritonavir, saquinavir)
Hydralazine
imatinib
levodopa
Lomitapide
macrolide antibiotics (e.g., clarithromycin, erythromycin)
mifepristone
Modafinil
Morphine
nefazodone
Obinutuzumab
other nitrates (e.g., nitroglycerin, isosorbide mononitrate)
Norfloxacin
Pentoxifylline
Phenytoin
medications for erectile dysfunction called phosphodiesterase 5 inhibitors (PDE-5 inhibitors; e.g., sildenafil, tadalafil, vardenafil)
prilocaine
primidone
rifabutin
rifampin
Riociguat
Rosiglitazone
St. John's wort
Sertraline
siltuximab
simeprevir
Tizanidine
Tocilizumab
tolcapone

If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

stop taking one of the medications,
change one of the medications to another,
change how you are taking one or both of the medications, or
leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with Isdn (Isosorbide-dinitrate). Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the Nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.

Before you begin taking a medication, be sure to inform your doctor of any medical conditions or Allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should take Isdn (Isosorbide-dinitrate).

Medical conditions: If you have Low Blood Pressure, Glaucoma, or Kidney Disease, discuss with your doctor how Isdn (Isosorbide-dinitrate) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Isdn (Isosorbide-dinitrate), and whether any special monitoring is needed.

Low Blood Pressure: When isosorbide dinitrate relaxes the blood vessels, the blood vessels become wider, allowing blood to flow more easily. This can cause blood pressure to decrease. While this usually isn't a problem, some people experience dizziness, headache or fainting, particularly when rising from a seated or lying position. If you have low blood pressure or experience these symptoms when you are taking isosorbide dinitrate, talk to your doctor.

Tolerance: The body can get used to the effects of isosorbide dinitrate (develop a tolerance), especially if the medication is taken throughout the day without a "nitrate-free period" (a 10 to 12-hour break from the medication). If you find that your symptoms of angina are getting worse or lasting longer, call your doctor.

Withdrawal: Stopping Isdn (Isosorbide-dinitrate) suddenly may occasionally aggravate chest pain or other symptoms of angina. To avoid possible withdrawal effects, isosorbide dinitrate should be gradually reduced and not stopped suddenly. Talk to your doctor about how to stop the medication safely.

Pregnancy: Isdn (Isosorbide-dinitrate) should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking Isdn (Isosorbide-dinitrate), contact your doctor immediately.

Breast-feeding: It is not known if isosorbide dinitrate passes into breast milk. If you are a breast-feeding mother and are taking Isdn (Isosorbide-dinitrate), it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.

Children: The safety and effectiveness of using Isdn (Isosorbide-dinitrate) have not been established for children.

Seniors: Seniors may be more likely to experience dizziness or lightheadedness taking isosorbide dinitrate.

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All material © 1996-2024 MediResource Inc. Terms and conditions of use. The contents herein are for informational purposes only. Always seek the advice of your physician or other qualified health providers with any questions you may have regarding a medical condition.

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