Before you begin using a medication, be sure to inform your doctor of any medical conditions or Allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use Aldurazyme (Laronidase).
HEALTH CANADA ADVISORY
Nov. 25, 2009
Health Canada has issued new restrictions concerning the use of Aldurazyme® (Aldurazyme (Laronidase)). To read the full Health Canada Advisory, visit Health Canada's web site at www.hc-sc.gc.ca.
Kidney or liver function: The safety and effectiveness of Aldurazyme (Laronidase) are not known in people with reduced kidney or liver function. People with reduced kidney or liver function should discuss with their doctor how Aldurazyme (Laronidase) may affect their medical condition, how their medical condition may affect the dosing and effectiveness of Aldurazyme (Laronidase), and whether any special monitoring is needed.
Premedication: Most people who receive Aldurazyme (Laronidase) will also be given medications (e.g., Acetaminophen, Diphenhydramine) to reduce infusion-related side effects such as fever, chills, headache, and flushing. These medications are usually given about 60 minutes before Aldurazyme (Laronidase) is given.
Pregnancy: Aldurazyme (Laronidase) should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while receiving Aldurazyme (Laronidase), contact your doctor immediately.
Breast-feeding: It is not known if Aldurazyme (Laronidase) passes into breast milk. If you are a breast-feeding mother and are receiving Aldurazyme (Laronidase), it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.
Children: The safety and effectiveness of using Aldurazyme (Laronidase) have not been established for children less than 6 months old.