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Jardiance

Jardiance

(empagliflozin)

Jardiance (Empagliflozin) belongs to the class of medications called oral antihyperglycemic agents. It works in the kidneys to increase the amount of glucose removed from the body by the kidneys.

Available form

Dosage

Tablet

10MG, 25MG

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Jardiance information

Dosage

Side Effects

Available Form

Contraindications

Precautions

Warnings

Do not give Jardiance (Empagliflozin) to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take Jardiance (Empagliflozin) if their doctor has not prescribed it.

How should I use Jardiance (Empagliflozin)?

The usual starting dose of Jardiance (Empagliflozin) is 10 mg taken by mouth once a day. Depending on how effectively it reduces your blood glucose, your doctor may increase the dose to 25 mg taken once a day.

Jardiance (Empagliflozin) may be taken at any time of the day, with or without food. The tablet must be swallowed whole. Do not cut or chew the tablets.

Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.

It is important to take Jardiance (Empagliflozin) exactly as prescribed by your doctor. If you miss a dose, take it as soon as possible and continue with your regular schedule. If it is less than 12 hours until your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

Store Jardiance (Empagliflozin) at room temperature, protect it from light and moisture, and keep it out of the reach of children.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.

The side effects listed below are not experienced by everyone who takes Jardiance (Empagliflozin). If you are concerned about side effects, discuss the risks and benefits of Jardiance (Empagliflozin) with your doctor.

The following side effects have been reported by at least 1% of people taking Jardiance (Empagliflozin). Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

dizziness when rising from a sitting or lying position
increased urination
itching
rash
symptoms of yeast infection of the penis (e.g., red, swollen, itchy head of penis, unpleasant odour, discharge under foreskin, pain passing urine or during sexual activity)
symptoms of vaginal yeast infection (e.g., itching, burning, soreness, whitish-grey discharge)
unusual thirst

Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

fainting
Low Blood Pressure
signs of dehydration (e.g., decreased urine, dry skin, dry and sticky mouth, sleepiness, dizziness, headache, thirst, confusion)
signs of infection that has spread from the urinary tract (e.g., Fever or chills, severe Diarrhea, shortness of breath, prolonged dizziness, headache, stiff neck, weight loss, or listlessness)
signs of kidney problems (e.g., increased urination at night, decreased urine production, blood in the urine, change of urine colour)
symptoms of low blood sugar (e.g., cold sweat, cool pale skin, headache, fast heartbeat, weakness)
symptoms of a urinary tract infection (e.g., pain when urinating, urinating more often than usual, low back or flank pain)

Stop taking the medication and seek immediate medical attention if any of the following occur:

pain, redness, or swelling in and around the anus or genitals, especially if accompanied by fever, tiredness, or weakness
signs of a serious allergic reaction (e.g., abdominal cramps, difficulty breathing, nausea and vomiting, or swelling of the face and throat)
signs of a serious skin reaction (e.g., skin rash; red skin; blistering of the lips, eyes, or mouth; skin peeling; fever; or joint pain)
symptoms of diabetic ketoacidosis (DKA; e.g., difficulty breathing, extreme thirst, vomiting, nausea, loss of appetite, stomach pain, confusion, unusual tiredness)

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking Jardiance (Empagliflozin).

There may be an interaction between Jardiance (Empagliflozin) and any of the following:

acetylsalicylic acid (Asa)
androgens (e.g., testosterone)
angiotensin converting enzyme inhibitors (ACEIs; Captopril, Enalapril, Ramipril)
atypical antipsychotics (e.g., Clozapine, Olanzapine, Quetiapine, Risperidone)
other diabetes medications (e.g., chlorpropamide, glipizide, Glyburide, insulin, Metformin, Rosiglitazone)
Disopyramide
diuretics (water pills; e.g., Furosemide, Hydrochlorothiazide, triamterene)
Duloxetine
estrogens (e.g., conjugated estrogen, Estradiol, ethinyl estradiol)
Everolimus
Glucagon
HIV protease inhibitors (e.g., atazanavir, indinavir, ritonavir, saquinavir)
inhaled corticosteroids (e.g., budesonide, ciclesonide, fluticasone)
Lanreotide
levodopa
mifepristone
monoamine oxidase inhibitors (M.O.S. e.g., Moclobemide, Phenelzine, Rasagiline, Selegiline, Tranylcypromine)
Niacin
Octreotide
oral corticosteroids (e.g., Dexamethasone, Hydrocortisone, Prednisone)
Pasireotide
pentamidine
progestins (e.g., Dienogest, Levonorgestrel, medroxyprogesterone, Norethindrone)
quinine
quinolone antibiotics (e.g., ciprofloxacin, Norfloxacin, Ofloxacin)
selective serotonin reuptake inhibitors (SSRIs; e.g., Citalopram, Fluoxetine, Paroxetine, Sertraline)
somatostatin
sulfonamide antibiotics ("sulfas"; e.g., sulfisoxazole, sulfamethoxazole)
Tacrolimus
Teriflunomide
Vorinostat

If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

stop taking one of the medications,
change one of the medications to another,
change how you are taking one or both of the medications, or
leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with Jardiance (Empagliflozin). Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the Nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.

Before you begin using a medication, be sure to inform your doctor of any medical conditions or Allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use Jardiance (Empagliflozin)..

HEALTH CANADA ADVISORY

May 16, 2016

Health Canada has issued new information concerning the use of Jardiance (Jardiance (Empagliflozin)). To read the full Health Canada Advisory, visit Health Canada's web site at www.hc-sc.gc.ca.

Diabetic ketoacidosis (DKA): Jardiance (Empagliflozin) has been associated with DKA. This is a potentially life-threatening condition caused by not having enough insulin in the blood to use the glucose in the bloodstream. When this happens, the body starts to burn ketones for fuel and can make the blood acidic. This condition is more likely to develop if you are following a very low carbohydrate diet, are dehydrated, or have consumed a large amount of alcohol. Symptoms of DKA include:

difficulty breathing
nausea
vomiting
abdominal pain
confusion
loss of appetite
excessive thirst
unusual fatigue or sleepiness

If you experience these symptoms, get immediate medical help.

Drowsiness/reduced alertness: Jardiance (Empagliflozin) may cause drowsiness or dizziness, affecting your ability to drive or operate machinery. Avoid these and other hazardous tasks until you have determined how Jardiance (Empagliflozin) affects you.

Fluid and electrolyte balance: Jardiance (Empagliflozin) causes increased urine production that may cause the levels of electrolytes such as potassium, sodium, magnesium, chloride, and calcium in the blood to change while taking Jardiance (Empagliflozin). If you experience symptoms of fluid and electrolyte imbalance such as muscle pains or cramps; Dry Mouth; numb hands, feet, or lips; or racing heartbeat, contact your doctor as soon as possible. Your doctor will do blood tests regularly to monitor the levels of these electrolytes in your blood while you are taking Jardiance (Empagliflozin).

Glucose control: When Jardiance (Empagliflozin) is taken along with other medications for diabetes, glucose levels may drop too far, causing confusion, cold sweats, cool and pale skin, headache, fast heartbeat, or weakness. Your doctor may suggest decreasing the dose of your other medications when you first start taking Jardiance (Empagliflozin). If you take other medications for diabetes, discuss with your doctor how Jardiance (Empagliflozin) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Jardiance (Empagliflozin), and whether any special monitoring is needed.

Kidney function: Jardiance (Empagliflozin) may cause a decrease in kidney function. If you have reduced kidney function or kidney disease, discuss with your doctor how Jardiance (Empagliflozin) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Jardiance (Empagliflozin), and whether any special monitoring is needed.

Low blood pressure: Jardiance (Empagliflozin) causes an increased amount of fluid to be removed from the body through the urine. As a result, it can cause decreases in blood pressure that may cause dizziness, especially when rising from a sitting or lying position. To reduce the possibility of dizziness or fainting, rise slowly from sitting or lying down.

Surgery: Jardiance (Empagliflozin) should be stopped temporarily for surgery (except for minor surgery where food and fluid intake is not restricted). You will be restarted on Jardiance (Empagliflozin) after surgery once you are eating and drinking again and your kidney function has been tested and is normal. Talk to your doctor for specific instructions.

Urinary tract infection: Jardiance (Empagliflozin) increases the risk of developing Urinary Tract Infections. If you experience symptoms of a urinary tract infection, such as increased need to urinate, burning sensation when urinating, cloudy urine, strong-smelling urine, or pelvic pain, contact your doctor.

Yeast infections: There is an increased risk of developing genital or vaginal yeast infections when taking Jardiance (Empagliflozin), as a result of increased glucose in the urine. This is more likely to occur for uncircumcised men and for people who have a history of yeast infections.

Pregnancy: Jardiance (Empagliflozin) should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking Jardiance (Empagliflozin), contact your doctor immediately.

Breast-feeding: It is not known if Jardiance (Empagliflozin) passes into breast milk. If you are a breast-feeding mother and are taking Jardiance (Empagliflozin), it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.

Children: The safety and effectiveness of using Jardiance (Empagliflozin) have not been established for children.

Seniors: Seniors are at an increased risk of experiencing urinary tract infections and decreases in blood pressure while taking Jardiance (Empagliflozin).

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