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Urozide

Urozide

(hydrochlorothiazide)

Urozide (Hydrochlorothiazide) belongs to the group of medications called diuretics. It is also an antihypertensive.

Available form

Dosage

Tablet

12.5MG, 25MG, 50MG

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Urozide information

Dosage

Side Effects

Available Form

Contraindications

Precautions

Warnings

To reduce fluid retention (edema), the usual recommended adult dose of Urozide (Hydrochlorothiazide) is 25 mg to 200 mg daily, given in 1 to 3 divided doses. Some people may only need to take Urozide (Hydrochlorothiazide) every other day, or for 3 to 5 days per week, as directed by their doctor. For infants and children, the dose is based on body weight and is given in 2 divided doses.

When treating toxemia of pregnancy, the recommended dose is usually 100 mg taken every day; however doses may range from 100 mg every day to 100 mg every 4 days. If needed, the dose may be increased to 200 mg daily for severe toxemia given in 2 divided doses and for short periods of time.

For the treatment of high blood pressure, the usual recommended adult dose of Urozide (Hydrochlorothiazide) is 12.5 mg to 50 mg daily.

When taken once daily, Urozide (Hydrochlorothiazide) should be taken in the morning to prevent the need to urinate during nighttime.

Many things can affect the dose of a medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.

It is important that Urozide (Hydrochlorothiazide) be taken exactly as prescribed by your doctor. If you miss a dose, take it as soon as possible and continue with your regular schedule. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

Store Urozide (Hydrochlorothiazide) at room temperature, protect it from light and moisture, and keep it out of the reach of children.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.

The side effects listed below are not experienced by everyone who takes Urozide (Hydrochlorothiazide). If you are concerned about side effects, discuss the risks and benefits of Urozide (Hydrochlorothiazide) with your doctor.

The following side effects have been reported by at least 1% of people taking Urozide (Hydrochlorothiazide). Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

Constipation
decreased sexual interest or ability
Diarrhea
dizziness or lightheadedness when getting up from a lying or sitting position
headache
increased sensitivity of skin to sunlight (skin rash, itching, redness, other discoloration of skin, or severe Sunburn after exposure to sunlight)
nausea
loss of appetite
pins and needles feeling in fingers
upset stomach
vomiting

Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

cough
joint pain
muscle cramps or spasms
muscle pain or weakness
pinpoint red spots on skin
signs of Anemia (low red blood cells; e.g., dizziness, pale skin, unusual tiredness or weakness, shortness of breath)
signs of clotting problems (e.g., unusual nosebleeds, bruising, blood in urine, coughing blood, bleeding gums, cuts that don’t stop bleeding)
signs of infection (symptoms may include Fever or chills, severe diarrhea, shortness of breath, prolonged dizziness, headache, stiff neck, weight loss, or listlessness)
signs of kidney problems (e.g., change in the amount or colour of urine, increased urination at night, blood in the urine, swelling in the feet or legs)
signs of liver problems (e.g., nausea, vomiting, diarrhea, loss of appetite, weight loss, yellowing of the skin or whites of the eyes, dark urine, pale stools)
signs of too much potassium loss (dryness of mouth, increased thirst, irregular heartbeat, mood or mental changes, muscle cramps or pain, nausea or vomiting, unusual tiredness or weakness, weak pulse)
signs of too much sodium loss (confusion, convulsions, decreased mental activity, irritability, muscle cramps, unusual tiredness or weakness)
skin growths or changes to existing skin moles or growths
skin rash or Hives
stomach pain (severe) with nausea and vomiting
tingling or burning sensation
vision changes (e.g., blurred vision, eye pain, increased pressure in the eye)

Seek immediate medical attention if any of the following occur:

signs of a serious allergic reaction (e.g., abdominal cramps, difficulty breathing, nausea and vomiting, or swelling of the face and throat)
signs of pancreatitis (e.g., abdominal pain on the upper left side, back pain, nausea, fever, chills, rapid heartbeat, swollen abdomen)
signs of a severe skin reaction such as blistering, peeling, a rash covering a large area of the body, a rash that spreads quickly, or a rash combined with fever or discomfort

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking Urozide (Hydrochlorothiazide).

Before you begin using a medication, be sure to inform your doctor of any medical conditions or Allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use Urozide (Hydrochlorothiazide).

HEALTH CANADA ADVISORY

January 31, 2019

Health Canada has issued new restrictions concerning the use of Urozide (Hydrochlorothiazide). To read the full Health Canada Advisory, visit Health Canada's web site at www.hc-sc.gc.ca.

Cholesterol: Increases in cholesterol and triglyceride levels may occur when taking Urozide (Hydrochlorothiazide). Your doctor will monitor your cholesterol and triglyceride levels with blood tests while you are taking Urozide (Hydrochlorothiazide).

Diabetes: Urozide (Hydrochlorothiazide) may make it more difficult for people with diabetes to control their blood sugar. If you have diabetes, discuss with your doctor how Urozide (Hydrochlorothiazide) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Urozide (Hydrochlorothiazide), and whether any special monitoring is needed.

Fluid and electrolyte balance: The levels of electrolytes such as potassium, sodium, magnesium, and chloride can be reduced with Urozide (Hydrochlorothiazide). Your doctor will monitor your electrolyte levels with blood tests while you are taking Urozide (Hydrochlorothiazide). Warning signs or symptoms of fluid and electrolyte imbalance include:

confusion
drowsiness
Dry Mouth
Low Blood Pressure
muscle pains or cramps
muscular fatigue
nausea and vomiting
racing heartbeat
restlessness
seizures
thirst
unusual tiredness
weakness

If you experience any of these symptoms, contact your doctor. To prevent low potassium levels, eat foods that are high in potassium (e.g., bananas, dried figs, dates, prunes, nuts). If your potassium level is low, your doctor may suggest a potassium supplement.

Glaucoma: Urozide (Hydrochlorothiazide) may cause the symptoms of glaucoma (increased pressure in the eye) to become worse. If you have glaucoma, discuss with your doctor how Urozide (Hydrochlorothiazide) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Urozide (Hydrochlorothiazide), and whether any special monitoring is needed. Report any changes in vision to your doctor as soon as possible while you are taking Urozide (Hydrochlorothiazide).

Gout: Urozide (Hydrochlorothiazide) may aggravate or cause gout. If you have high levels of uric acid in your blood or a history of gout, discuss with your doctor how Urozide (Hydrochlorothiazide) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Urozide (Hydrochlorothiazide), and whether any special monitoring is needed.

Kidney function: Urozide (Hydrochlorothiazide) may cause changes in kidney function. If you have reduced kidney function, discuss with your doctor how Urozide (Hydrochlorothiazide) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Urozide (Hydrochlorothiazide), and whether any special monitoring is needed.

Liver disease: If you have reduced liver function or progressive liver disease, discuss with your doctor how Urozide (Hydrochlorothiazide) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Urozide (Hydrochlorothiazide), and whether any special monitoring is needed.

Low blood pressure when standing: Urozide (Hydrochlorothiazide) can cause low blood pressure when standing from a sitting or lying position (also called orthostatic hypotension). Alcohol and other medications such as Phenobarbital and other medications to treat high blood pressure can increase the chances that this will happen. If you are taking these medications, your doctor may change the dose of these medications and increase them slowly to reduce the chance of you experiencing this.

Sensitivity to sunlight: Urozide (Hydrochlorothiazide) may increase the sensitivity of the skin to sunlight, increasing the risk of sunburn. Avoid exposure to sunlight for long periods of time, particularly between the hours of 10 am and 2 pm, while you are taking Urozide (Hydrochlorothiazide) and for 7 days after completing treatment. Wear a broad-spectrum sunscreen and lip balm with an SPF of 30 or higher. If you notice any unusual skin rash or peeling, contact your doctor immediately.

Skin Cancer: Long-term use of Urozide (Hydrochlorothiazide) has recently been connected to an increased risk of developing non-melanoma skin cancer. Talk to your doctor about any concerns you may have.

Systemic Lupus erythematosus: Urozide (Hydrochlorothiazide) can worsen or activate the symptoms of lupus. If you experience swollen and painful joints, fever, fatigue, or rash on the nose and cheeks while taking Urozide (Hydrochlorothiazide), contact your doctor.

Pregnancy: Urozide (Hydrochlorothiazide) should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking Urozide (Hydrochlorothiazide), contact your doctor immediately.

Breast-feeding: Urozide (Hydrochlorothiazide) passes into breast milk. If you are a breast-feeding mother and are taking Urozide (Hydrochlorothiazide), it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.

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