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Topamax

Topamax

(topiramate)

Topamax (Topiramate) belongs to a group of medications that are used to treat Epilepsy. It works by affecting chemicals in the brain that are involved in sending signals to nerves.

Available form

Dosage

Tablet

25MG, 50MG, 100MG, 200MG

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Topamax information

Dosage

Side Effects

Available Form

Contraindications

Precautions

Warnings

When used alone for the treatment of epilepsy, the recommended starting dose of Topamax (Topiramate) for adults and children 6 years of age and older is 25 mg daily, increasing to a usual dose of 100 mg daily in 2 divided doses. The maximum recommended dose is 400 mg daily.

When used in combination with other epilepsy medications, the recommended adult dose of Topamax (Topiramate) starts at 25 mg to 50 mg daily, increasing to a usual dose of 200 mg to 400 mg daily in 2 divided doses. The maximum recommended dose is 800 mg daily. The recommended dose for children aged 2 to 16 years starts at 25 mg daily (or 1 mg to 3 mg per kilogram of body weight), increasing to a usual dose of 5 mg to 9 mg per kilogram per day in 2 divided doses.

For migraine prevention, the usual starting dose of Topamax (Topiramate) is 25 mg daily, increasing to a usual dose of 100 mg daily in 2 divided doses.

The tablets can be taken with or without food. Topamax (Topiramate) tablets should not be broken, crushed, or chewed. The sprinkle capsules can be swallowed whole or opened and sprinkled on a small amount (teaspoon) of soft food. The medication and food should be swallowed immediately and not chewed.

If it becomes necessary to stop taking Topamax (Topiramate), the dose should be gradually reduced to prevent a return of seizures or migraines. Talk to your doctor before stopping the medication.

Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.

It is important to take Topamax (Topiramate) exactly as prescribed by your doctor. If you miss a dose, take it as soon as possible and continue with your regular schedule. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

Store Topamax (Topiramate) at room temperature, protect it from light and moisture, and keep it out of the reach of children.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.

The side effects listed below are not experienced by everyone who takes Topamax (Topiramate). If you are concerned about side effects, discuss the risks and benefits of Topamax (Topiramate) with your doctor.

The following side effects have been reported by at least 1% of people taking Topamax (Topiramate). Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

altered taste
Constipation
decreased appetite
dizziness
drowsiness
fatigue
headache
nausea

Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

aggressive behaviour
agitation
burning or tingling sensations
confusion
coordination problems
difficulty concentrating or slow thinking
memory problems
mood swings
nervousness
signs of Depression (e.g., poor concentration, changes in weight, changes in sleep, decreased interest in activities, thoughts of suicide)
signs of high blood ammonia (e.g., decreased alertness, tiredness, vomiting)
signs of Kidney Stones (e.g., flank pain, blood in urine, pain in lower back)
signs of metabolic acidosis (e.g., unexplained tiredness, loss of appetite, decreased consciousness)
speech disorders (e.g., hesitancy or word-finding difficulty)
unexplained tiredness, vomiting, or confusion
more frequent upper respiratory tract infections (e.g., colds, Bronchitis)
weight loss

Stop taking the medication and seek immediate medical attention if any of the following occur:

decreased sweating and increased body temperature
signs of a serious allergic reaction (e.g., abdominal cramps, difficulty breathing, nausea and vomiting, or swelling of the face and throat)
signs of severe skin reactions (e.g., blistering, peeling, a rash covering a large area of the body, a rash that spreads quickly, or a rash combined with Fever or discomfort)
sudden vision change (e.g., blurred vision, painful red eyes, vision loss)
thoughts of self-harm or suicide

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking Topamax (Topiramate).

Tablets

25 mg
Each white, embossed, round, coated tablet, marked "TOP" on one side and "25" on the other, contains 25 mg of Topamax (Topiramate). Nonmedicinal ingredients: carnauba wax, hypromellose, lactose monohydrate, magnesium stearate, pregelatinized starch, microcrystalline cellulose, polyethylene glycol, polysorbate 80, purified water, sodium starch glycolate, and titanium dioxide; may contain synthetic iron oxide.

100 mg
Each yellow, embossed, round, coated tablet, marked "TOP" on one side and "100" on the other, contains 100 mg of Topamax (Topiramate). Nonmedicinal ingredients: carnauba wax, hypromellose, lactose monohydrate, magnesium stearate, pregelatinized starch, microcrystalline cellulose, polyethylene glycol, polysorbate 80, purified water, sodium starch glycolate, and titanium dioxide; may contain synthetic iron oxide.

200 mg
Each salmon, embossed, round, coated tablet, marked "TOP" on one side and "200" on the other, contains 200 mg of Topamax (Topiramate). Nonmedicinal ingredients: carnauba wax, hypromellose, lactose monohydrate, magnesium stearate, pregelatinized starch, microcrystalline cellulose, polyethylene glycol, polysorbate 80, purified water, sodium starch glycolate, and titanium dioxide; may contain synthetic iron oxide.

Sprinkle Capsules

15 mg
Each white, clear gelatin capsule, containing small white-to-off-white spheres, marked "TOP" and "15 mg" on the side, contains 15 mg of topiramate-coated beads. Nonmedicinal ingredients: black pharmaceutical ink, cellulose acetate, gelatin, povidone, sorbitan monolaurate, sodium lauryl sulfate, sugar spheres (sucrose and starch), and titanium dioxide.

25 mg
Each white, clear gelatin capsule, containing small white-to-off-white spheres, marked "TOP" and "25 mg" on the side, contains 25 mg of topiramate-coated beads. Nonmedicinal ingredients: black pharmaceutical ink, cellulose acetate, gelatin, povidone, sorbitan monolaurate, sodium lauryl sulfate, sugar spheres (sucrose and starch), and titanium dioxide.

Before you begin using a medication, be sure to inform your doctor of any medical conditions or Allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use Topamax (Topiramate).

Ammonia: Topamax (Topiramate) may cause elevated levels of ammonia in the blood, which can cause changes in mental alertness. If you have symptoms of decreased alertness, confusion, tiredness, vomiting, or a low body temperature (less than 35°C), contact your doctor immediately.

Birth control: Topamax (Topiramate) has been shown to affect birth control pills that contain low doses of estrogen. If you are taking birth control pills, your pill should contain no less than 30 µg of estrogen. Report any changes in bleeding patterns to your doctor.

Depression: Topamax (Topiramate) may contribute to mood swings and symptoms of depression. If you have depression or a history of depression, discuss with your doctor how Topamax (Topiramate) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Topamax (Topiramate), and whether any special monitoring is needed. If you experience symptoms of depression such as poor concentration, changes in weight, changes in sleep, decreased interest in activities, or notice them in a family member who is taking Topamax (Topiramate), contact your doctor as soon as possible.

Drowsiness/reduced alertness: Topamax (Topiramate) can cause difficulty with concentration, speech or language problems, and drowsiness or fatigue. If you are taking Topamax (Topiramate) you should not drive or operate machinery until you have had a chance to see if it affects your mental or physical performance.

Heat regulation: For some people, especially children, Topamax (Topiramate) may cause decreased sweating and increased body temperature. Let your doctor know if you or a child taking Topamax (Topiramate) experiences these symptoms. You should make sure you are properly hydrating during exposure to warm temperatures, as well as before and during exercise.

Kidney function: Kidney Disease or reduced kidney function may cause Topamax (Topiramate) to build up in the body, causing side effects. If you have reduced kidney function or kidney disease, discuss with your doctor how Topamax (Topiramate) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Topamax (Topiramate), and whether any special monitoring is needed.

Kidney stones: Approximately 2% of people taking Topamax (Topiramate) develop kidney stones. Men seem to be at greater risk for this. Be sure to drink plenty of fluids while taking Topamax (Topiramate) in order to reduce the risk of kidney stone formation. If you experience pain in the kidney or flank areas, contact your doctor to have this investigated.

Laboratory tests: Topamax (Topiramate) may decrease sodium bicarbonate levels and lead to metabolic acidosis. If you experience shallow, rapid breathing, unusual tiredness and loss of appetite, contact your doctor. Sodium bicarbonate levels should be monitored by your doctor with blood tests, while you are taking Topamax (Topiramate).

Liver function: Liver disease or reduced liver function may cause Topamax (Topiramate) to build up in the body, causing side effects. If you have liver problems, discuss with your doctor how Topamax (Topiramate) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Topamax (Topiramate), and whether any special monitoring is needed. Your doctor may want to test your liver function regularly with blood tests while you are taking Topamax (Topiramate).

Suicidal or agitated behaviour: People taking Topamax (Topiramate) may feel agitated (restless, anxious, aggressive, emotional, and feeling not like themselves), or they may want to hurt themselves or others. These symptoms may occur within several weeks after starting Topamax (Topiramate). If you experience these side effects or notice them in a family member who is taking Topamax (Topiramate), contact your doctor immediately. You should be closely monitored by your doctor for emotional and behaviour changes while taking Topamax (Topiramate).

Stopping treatment: If you are taking Topamax (Topiramate) to control seizures, it should be stopped gradually to decrease the risk of seizures. If it is necessary to stop taking Topamax (Topiramate), discuss with your doctor the best way to reduce your dose gradually. Do not stop taking Topamax (Topiramate) without talking to your doctor.

Vision changes: Topamax (Topiramate) may cause the symptoms of Glaucoma (increased pressure in the eye) to become worse. If you have glaucoma, discuss with your doctor how Topamax (Topiramate) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Topamax (Topiramate), and whether any special monitoring is needed. If you are taking Topamax (Topiramate) you should immediately report blurred vision or painful and red eyes to a doctor. If left untreated, these symptoms can lead to permanent vision loss.

Pregnancy: Topamax (Topiramate) may cause harm to the developing baby if it is taken by a woman while she is pregnant. Topamax (Topiramate) should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking Topamax (Topiramate), contact your doctor immediately.

Breast-feeding: Topamax (Topiramate) may pass into breast milk. If you are breast-feeding and taking Topamax (Topiramate), it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.

Children and adolescents: Topamax (Topiramate) can be used in children aged 2 and older for seizures. The safety and effectiveness of using Topamax (Topiramate) have not been established for children under the age of 2. The safety and effectiveness of using Topamax (Topiramate) to prevent migraine headaches has not been established for children less than 18 years of age.

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All material © 1996-2024 MediResource Inc. Terms and conditions of use. The contents herein are for informational purposes only. Always seek the advice of your physician or other qualified health providers with any questions you may have regarding a medical condition.

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