Isosorbide-5-mononitrate belongs to the family of medications known as anti-anginals. Pms Ismn (Isosorbide-mononitrate) is used to prevent Angina attacks associated with Coronary Artery Disease. It is not useful for the quick relief of an attack.

It acts by opening up the blood vessels that supply the heart, increasing the blood and oxygen supply to the heart. Isosorbide-5-mononitrate may reduce the number, length, and severity of angina attacks. Tolerance to exercise may be increased and the need for fast-acting Nitroglycerin (tablets and spray) may be reduced.

Pms Ismn (Isosorbide-mononitrate) may be available under multiple brand names and/or in several different forms. Any specific brand name of Pms Ismn (Isosorbide-mononitrate) may not be available in all of the forms or approved for all of the conditions discussed here. As well, some forms of Pms Ismn (Isosorbide-mononitrate) may not be used for all of the conditions discussed here.

Your doctor may have suggested Pms Ismn (Isosorbide-mononitrate) for conditions other than those listed in these drug information articles. If you have not discussed this with your doctor or are not sure why you are taking Pms Ismn (Isosorbide-mononitrate), speak to your doctor. Do not stop taking Pms Ismn (Isosorbide-mononitrate) without consulting your doctor.

Do not give Pms Ismn (Isosorbide-mononitrate) to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take Pms Ismn (Isosorbide-mononitrate) if their doctor has not prescribed it.

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The recommended adult dose of isosorbide-5-mononitrate is 1 tablet (60 mg) taken once daily in the morning. Your doctor may increase the dose to 2 tablets (120 mg) once daily in the morning if necessary. To reduce the risk of headache, your doctor may suggest starting with one-half tablet (30 mg) once daily each morning for the first 2 to 4 days.

Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.

The tablets should not be chewed or crushed, and should be swallowed together with half a glass of water. If necessary, the tablet may be split in half and the half tablet may be swallowed whole. You may sometimes find whole tablets in the stool. These are only the shell of the tablet, and you can be sure that the medication has been released.

The tablets are available in a 30-day package that is designed to make it easy to keep track of your medication. 28 tablets are labeled with a day of the week. To start, take a tablet in the first row that matches the day you begin this pack. Then take a tablet on each of the following days to complete the 28 labelled tablets. The 2 extra non-labelled tablets should be taken after all the other tablets are gone.

It is important to take Pms Ismn (Isosorbide-mononitrate) exactly as prescribed by your doctor. Isosorbide-5-mononitrate should be taken at about the same time every day. If you miss a dose and remember within 6 hours, take your usual dose as soon as possible, then go back to your regular schedule. If it has been more than 6 hours when you remember, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

Store Pms Ismn (Isosorbide-mononitrate) at room temperature, protect it from light and moisture, and keep it out of the reach of children.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.

The side effects listed below are not experienced by everyone who takes Pms Ismn (Isosorbide-mononitrate). If you are concerned about side effects, discuss the risks and benefits of Pms Ismn (Isosorbide-mononitrate) with your doctor.

The following side effects have been reported by at least 1% of people taking Pms Ismn (Isosorbide-mononitrate). Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

• abdominal pain
• Constipation
• Diarrhea
• dizziness or lightheadedness, especially when rising from a lying or sitting position
• flushing of face and neck
• gas
• headache
• increased sweating
• nausea
• restlessness
• sensation of spinning
• trouble sleeping

Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

• blurred vision
• chest pain (angina pain)
• heartburn
• rapid or pounding heartbeat
• severe or prolonged headache

Stop taking the medication and seek immediate medical attention if any of the following occur:

• signs of a Heart Attack (e.g., chest pain or pressure, pain extending through shoulder and arm, nausea and vomiting, sweating)

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking Pms Ismn (Isosorbide-mononitrate).

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Each yellow, oval, biconvex, film-coated tablet, scored on both sides with "P" on one side of the scored line on one side of the tablet, contains 60 mg of isosorbide-5-mononitrate. Nonmedicinal ingredients: colloidal silicon dioxide, hydroxypropyl methylcellulose, iron oxide yellow, lactose, magnesium stearate, microcrystalline cellulose, polyethylene glycol, talc, and titanium dioxide.

Do not take Pms Ismn (Isosorbide-mononitrate) if you:

• are allergic to isosorbide-5-mononitrate or any ingredients of Pms Ismn (Isosorbide-mononitrate)
• are allergic to other nitrates or nitrites
• are in a state of acute circulatory failure associated with extremely Low Blood Pressure (e.g., states of shock or collapse)
• are taking Sildenafil, Tadalafil, or Vardenafil
• experience dizziness, blurred vision, or loss of consciousness when rising from a sitting or lying position
• have increased pressure inside the head
• have myocardial insufficiency due to obstruction
• have severe Anemia

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There may be an interaction between isosorbide-5-mononitrate and any of the following:

• Abiraterone acetate
• alcohol
• Amiodarone
• Aprepitant
• angiotensin converting enzyme (ACE) inhibitors (e.g., Captopril, Lisinopril, Ramipril)
• antipsychotics (e.g., Haloperidol, Quetiapine, Risperidone)
• "azole" antifungal agents (e.g., itraconazole, ketoconazole, Voriconazole)
• benzodiazepines (e.g., Alprazolam, Diazepam, midazolam, Triazolam)
• beta-blockers (e.g., Carvedilol, Propranolol, Timolol)
• Bicalutamide
• boceprevir
• Bosentan
• calcium channel blockers (e.g., Amlodipine, Diltiazem, Verapamil, Nifedipine)
• Carbamazepine
• Cobicistat
• conivaptan
• Crizotinib
• Dabrafenib
• Dapsone
• Dasatinib
• Deferasirox
• diuretics (water pills; e.g., Furosemide, Hydrochlorothiazide, Spironolactone)
• Dronedarone
• Enzalutamide
• grapefruit juice
• HIV non-nucleoside reverse transcriptase inhibitors (NNRTIs; e.g., delavirdine, efavirenz, etravirine, nevirapine)
• HIV protease inhibitors (e.g., atazanavir, indinavir, ritonavir, saquinavir)
• imatinib
• macrolide antibiotics (e.g., clarithromycin, erythromycin)
• mifepristone
• nefazodone
• Norfloxacin
• Phenobarbital
• Phenytoin
• phosphodiesterase-5 inhibitors (e.g., sildenafil, taladafil, vardenafil)
• prilocaine
• primidone
• rifabutin
• rifampin
• Rosiglitazone
• St. John's wort
• siltuximab
• simeprevir
• Stiripentol
• tetracaine
• Tocilizumab

If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:

• stop taking one of the medications,
• change one of the medications to another,
• change how you are taking one or both of the medications, or
• leave everything as is.

An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.

Medications other than those listed above may interact with Pms Ismn (Isosorbide-mononitrate). Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Also tell them about any supplements you take. Since caffeine, alcohol, the Nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.

Before you begin using a medication, be sure to inform your doctor of any medical conditions or Allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use Pms Ismn (Isosorbide-mononitrate).

Drowsiness/reduced alertness: Pms Ismn (Isosorbide-mononitrate) may cause faintness or dizziness. Do not drive, operate machinery, or perform other potentially hazardous tasks until you have determined how Pms Ismn (Isosorbide-mononitrate) affects you.

Heart disease: Isosorbide-5-mononitrate may cause some symptoms of heart disease to become worse. If you have heart problems caused by not enough oxygen being available for the heart or other organs of the body, discuss with your doctor how Pms Ismn (Isosorbide-mononitrate) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Pms Ismn (Isosorbide-mononitrate), and whether any special monitoring is needed.

Low blood pressure: Some people who take Pms Ismn (Isosorbide-mononitrate) experience symptoms of a severe decrease in blood pressure, such as weakness or dizziness. This is more likely to happen when rising suddenly from a sitting or lying position. If it persists or if you faint, contact your doctor. People who have or have had heart disease, Stroke, "mini-stroke", or are at risk of experiencing low blood pressure (e.g., dehydration, taking medications for high blood pressure) should discuss with their doctor how Pms Ismn (Isosorbide-mononitrate) may affect their medical condition, how their medical condition may affect the dosing and effectiveness of Pms Ismn (Isosorbide-mononitrate), and whether any special monitoring is needed.

Tolerance: With continued use, isosorbide-5-mononitrate may stop having beneficial effects because the body gets used to it (i.e., develops a tolerance). Call your doctor if at any time you feel that your angina attacks are getting worse or happening more often.

Withdrawal: Stopping Pms Ismn (Isosorbide-mononitrate) suddenly may occasionally aggravate chest pain or other symptoms of angina. To avoid possible withdrawal effects, Pms Ismn (Isosorbide-mononitrate) should be gradually reduced and not stopped suddenly. Do not change the way you are taking Pms Ismn (Isosorbide-mononitrate) without speaking to your doctor.

Pregnancy: Studies demonstrating the safety and effectiveness of using isosorbide-5-mononitrate during pregnancy are not available. Pms Ismn (Isosorbide-mononitrate) should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking Pms Ismn (Isosorbide-mononitrate), contact your doctor immediately.

Breast-feeding: It is not known if isosorbide-5-mononitrate passes into breast milk. If you are a breast-feeding mother and are taking Pms Ismn (Isosorbide-mononitrate), it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.

Children: The safety and effectiveness of using Pms Ismn (Isosorbide-mononitrate) have not been established for children. Its use by this age group is not recommended.

Seniors: Seniors may be more likely to experience dizziness or lightheadedness while taking Pms Ismn (Isosorbide-mononitrate).

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