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Picato

Picato

(ingenol-mebutate)

Ingenol is used for the topical treatment of Actinic Keratosis, a condition associated with thick, hard and scaly skin patches caused by too much sun exposure. It works by killing skin cells and by causing inflammation where it is applied.

Available form

Dosage

Gel

0.015%

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Picato information

Dosage

Side Effects

Available Form

Contraindications

Precautions

Warnings

For the treatment of actinic keratosis on the face and scalp, use one unit dosed tube of 0.015% gel once daily for 3 days in a row.

For the treatment of actinic keratosis on the body, arms, hands and legs, use one unit dosed tube of 0.05% gel once daily for 2 days in a row.

Always use a new unit dosed tube each time you apply Picato (Ingenol-mebutate). The contents of each tube can cover about a 5 cm x 5 cm patch of skin.

To apply the gel, squeeze the gel onto your fingertip and gently rub the gel over the affected area of skin. Allow it to dry for 15 minutes. After applying the gel, wash your hands immediately. If you are treating your hands, only wash the fingertip you used to apply the gel. Do not touch the area yourself or allow anyone or any pets to touch the treated area for a period of 6 hours after applying the gel. Do not wash the treated area for 6 hours after applying the gel and do not apply it immediately after taking a shower or less than 2 hours before bedtime. Do not cover the treated area with a bandage or other types of dressings.

Many things can affect the dose of a medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are using the medication without consulting your doctor.

It is important to use Picato (Ingenol-mebutate) exactly as prescribed by your doctor. If you miss a dose, contact your doctor. Do not apply more gel to make up for a missed application. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

Store Picato (Ingenol-mebutate) in the refrigerator, and keep it out of the reach of children and pets.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

Before you begin using a medication, be sure to inform your doctor of any medical conditions or Allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use Picato (Ingenol-mebutate).

HEALTH CANADA ADVISORY

October 27, 2020

Health Canada has issued new restrictions concerning the use of ingenol. To read the full Health Canada Advisory, visit Health Canada's web site at www.hc-sc.gc.ca.

Proper use: Picato (Ingenol-mebutate) should only be applied to the skin. Do not apply the gel on the inside of the nostrils, on the inside of the ears, on the lips, or on skin outside the treatment area as defined by your doctor. Make sure that the skin has healed from the other treatments or surgery before applying ingenol. If the gel is accidently applied to these areas, rinse thoroughly with mild soap and water.

If Picato (Ingenol-mebutate) is accidentally swallowed, drink plenty of water and get immediate medical attention.

Eyes: Picato (Ingenol-mebutate) can cause swelling around the eyes and eye lids, eye swelling, eye pain, and a droopy eyelid. If these effects occur, they go way over time without long-lasting effects. Since ingenol can irritate and cause burn injuries to the eyes, avoid getting the gel in the eyes. If the gel does get in the eyes, flush them immediately with large amounts of water, and seek immediate medical attention.

Skin: Skin reactions such as redness, flaking or scaling, crusting, swelling, and blistering or ulceration may occur starting from the first day of treatment and may worsen up to one week after you have finished using ingenol. These will usually get better within 2 weeks from when you started treatment on the face and scalp, and within 4 weeks from when you started treatment on the body, arms, hands and legs. If these reactions do not improve, see your doctor.

Pregnancy: Picato (Ingenol-mebutate) has not been studied in pregnant women. It is recommended to avoid using ingenol during pregnancy.

Breast-feeding: If you are a breast-feeding mother, avoid physical contact between the treatment area and your infant for a period of 6 hours after applying ingenol.

Children: The safety and effectiveness of using Picato (Ingenol-mebutate) have not been established for children under the age of 18 years.

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