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Nplate

Nplate

(romiplostim)

Nplate (Romiplostim) belongs to a class of medications called thrombopoiesis-stimulating proteins. Nplate (Romiplostim) is a medication used to treat low platelet levels in people with immune (idiopathic) thrombocytopenic purpura (ITP).

Available form

Dosage

Injectable Powder

250MCG

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Nplate information

Dosage

Side Effects

Available Form

Contraindications

Precautions

Warnings

The recommended starting dose of Nplate (Romiplostim) is based on body weight and calculated as 1 µg per kilogram of body weight.

Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are using the medication without consulting your doctor.

Nplate (Romiplostim) is given as an injection under the skin (subcutaneous) once weekly.

People taking romiplostin will need to have their platelet levels checked regularly. Your doctor will order blood tests to do this. The doctor may adjust the dose of Nplate (Romiplostim) based on these test results to ensure that the proper amount of medication is being given to maintain their platelet levels.

It is important Nplate (Romiplostim) be given exactly as recommended by your doctor. If you miss an appointment to receive Nplate (Romiplostim), contact your doctor as soon as possible to reschedule your appointment.

Nplate (Romiplostim) does not contain preservatives and must be mixed with sterile water for injection before a subcutaneous injection is given. Once the powder has been mixed, it should be used within 24 hours. The mixed powder can remain at room temperature (25°C) or can be refrigerated at 2°C to 8°C for up to 24 hours prior to injection. The mixed powder must be protected from light.

Store Nplate (Romiplostim) in the refrigerator at 2°C to 8°C (do not freeze), protect it from light, and keep it out of the reach of children.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.

The side effects listed below are not experienced by everyone who takes Nplate (Romiplostim). If you are concerned about side effects, discuss the risks and benefits of Nplate (Romiplostim) with your doctor.

The following side effects have been reported by at least 1% of people taking Nplate (Romiplostim). Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

abdominal pain
Diarrhea
dizziness
fatigue
gas
headache
heartburn or indigestion
joint pain
muscle pain or weakness
nausea
pain in your hands and feet
shoulder pain
tingling or numbness of the hands or feet
trouble sleeping

Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not check with your doctor or seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

blurred vision
bone marrow changes (retiuclin or increased bone marrow fibres) – this finding can only be diagnosed by your doctor with special testing
rash
signs of Anemia (low red blood cells; e.g., pale skin, unusual tiredness or weakness)
signs of bleeding (e.g., nosebleeds, blood in urine, coughing blood, bleeding gums, cuts that don’t stop bleeding, unusual bruising, bloody, black, or tarry stools, or vomiting blood or material that looks like coffee grounds)
signs of infection (symptoms may include Fever or chills, severe diarrhea, shortness of breath, prolonged dizziness, headache, stiff neck, weight loss, or listlessness)

Stop taking the medication and seek immediate medical attention if any of the following occur:

burning pain, redness, and warmth of the feet and hands
if you have stopped taking Nplate (Romiplostim) and experience any symptoms related to your ITP condition that you had before starting treatment, including bleeding
signs of a serious allergic reaction (e.g., abdominal cramps, difficulty breathing, nausea and vomiting, or swelling of the face and throat)
symptoms of a blood clot (such as headache, tingling in hands or feet, swelling and redness in areas such as the calf)

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking this medication.

Before you begin using a medication, be sure to inform your doctor of any medical conditions or Allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use Nplate (Romiplostim).

Bleeding: Serious bleeding can occur while taking Nplate (Romiplostim). Your doctor will monitor you closely by having you take regular blood and lab tests while you are taking Nplate (Romiplostim). If you stop taking Nplate (Romiplostim), your platelet levels may drop, which can put you at risk for serious or life-threatening bleeding. If you experience any signs or symptoms of bleeding (e.g., black and tarry stools, blood in the urine, easy bruising, cuts that won't stop bleeding), contact your doctor immediately.

Blood clots: Nplate (Romiplostim) increases the amount of platelets in your blood to help prevent bleeding. This can also put you at risk of having an unwanted blood clot. If you experience any signs or symptoms of a blood clot (e.g., headache, tingling in hands or feet, swelling and redness in areas such as the calf), contact your doctor immediately.

Blood disorders: If you have blood disorders other than ITP (including blood cancers), discuss with your doctor how Nplate (Romiplostim) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Nplate (Romiplostim), and whether any special monitoring is needed.

Bone marrow: Using Nplate (Romiplostim) for a long period of time may cause changes in your bone marrow, which can lead your body to make abnormal blood cells or fewer blood cells. These signs of bone marrow changes show up in blood tests. Your doctor will monitor you carefully while you are taking Nplate (Romiplostim).

Kidney function: If you have reduced kidney function or Kidney Disease, discuss with your doctor how Nplate (Romiplostim) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.

Liver function: If you have reduced liver function or liver disease, discuss with your doctor how Nplate (Romiplostim) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Nplate (Romiplostim), and whether any special monitoring is needed.

Pregnancy: Nplate (Romiplostim) should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking this medication, contact your doctor immediately.

Breast-feeding: It is not known if Nplate (Romiplostim) passes into breast milk. If you are a breast-feeding mother and are taking Nplate (Romiplostim), it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.

Children: The safety and effectiveness of using Nplate (Romiplostim) have not been established for children.

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All material © 1996-2024 MediResource Inc. Terms and conditions of use. The contents herein are for informational purposes only. Always seek the advice of your physician or other qualified health providers with any questions you may have regarding a medical condition.

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