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Ninlaro

Ninlaro

(ixazomib)

Ninlaro (Ixazomib) belongs to the group of cancer-fighting medications known as antineoplastics, and specifically to the family of medications called reversible proteasome inhibitors. It is used in addition to other medications (Lenalidomide and Dexamethasone) to treat adults with Multiple Myeloma for whom at least one other type of medication has not successfully treated the cancer.

Available form

Dosage

Capsule

2.3MG

Buy Ninlaro Full drug details

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Ninlaro information

Dosage

Side Effects

Available Form

Contraindications

Precautions

Warnings

The usual dose of Ninlaro (Ixazomib) is 4 mg taken by mouth on days 1, 8, and 15 of a 28-day cycle. Your doctor may adjust your dose based on how well you tolerate the medication.

Ninlaro (Ixazomib) should be taken on an empty stomach at least 1 hour before eating or 2 hours after eating. Swallow the capsule whole with water. Do not crush, chew, or open the capsule.

Avoid touching the contents of the capsule with bare skin. If your skin does touch the powder inside the capsule, wash the area with soap and water.

Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.

It is important to take Ninlaro (Ixazomib) exactly as prescribed by your doctor. If you vomit after taking a dose of Ninlaro (Ixazomib), do not take another dose. Continue with your regular dosing schedule.

If you miss a dose, take it as soon as possible and continue with your regular schedule. If it is less than 3 days until your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.

Store Ninlaro (Ixazomib) at room temperature in its original package, protect it from light and moisture, and keep it out of the reach of children.

Do not dispose of medications in wastewater (e.g. down the sink or in the toilet) or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.

The side effects listed below are not experienced by everyone who takes Ninlaro (Ixazomib). If you are concerned about side effects, discuss the risks and benefits of Ninlaro (Ixazomib) with your doctor.

The following side effects have been reported by at least 1% of people taking Ninlaro (Ixazomib). Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

arm, leg, back, or joint pain
Constipation
cough
decreased appetite
Diarrhea
dizziness
dry eyes
fatigue
headache
muscle spasms or cramps
nausea
redness in whites of the eye
itchy or red skin rash
trouble sleeping
vomiting
weakness

Although most of the side effects listed below don't happen very often, they could lead to serious problems if you do not seek medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

blurred vision or vision changes
changes in mental status
Fever
frequent cold or cold-like symptoms
not able to move legs
muscle weakness
numbness, tingling, or burning sensation or pain in arms or legs
rash with skin peeling and mouth sores
red to purple bumps on skin
shortness of breath
signs of Anemia (low red blood cells; e.g., dizziness, pale skin, unusual tiredness or weakness, shortness of breath)
signs of bleeding (e.g., bloody nose, blood in urine, coughing blood, cuts that don't stop bleeding, black stools)
signs of fluid build-up in the body or edema (e.g., rapid weight gain, swelling of ankles or feet)
signs of infection (symptoms may include fever or chills, severe diarrhea, shortness of breath, prolonged dizziness, headache, stiff neck, weight loss, or listlessness)
signs of liver problems (e.g., nausea, vomiting, diarrhea, loss of appetite, weight loss, yellowing of the skin or whites of the eyes, dark urine, pale stools)
symptoms of low potassium levels in the blood (e.g., weakness, fatigue, muscle cramps, irregular heartbeat)
symptoms of a lung infection (LRTI) (e.g., shortness of breath, cough, chest pain)
symptoms of Shingles (e.g., painful blisters, rash on a small area of skin on one side of the face or body)

Stop taking the medication and seek immediate medical attention if any of the following occur:

seizures
signs of a serious allergic reaction (e.g., abdominal cramps, difficulty breathing, nausea and vomiting, swelling of the face and throat)
symptoms of Blood Clots in small blood vessels (e.g., weakness, nausea, vomiting, fatigue, fever, bruising, bleeding, swelling, confusion, vision loss, seizures)
symptoms of tumour lysis syndrome (rapid death of cancer cells; e.g., dizziness, decreased urination, confusion, vomiting, nausea, swelling, shortness of breath, heart rhythm changes)

Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking Ninlaro (Ixazomib).

Before you begin using a medication, be sure to inform your doctor of any medical conditions or Allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use Ninlaro (Ixazomib).

Anemia: Ninlaro (Ixazomib) may cause low levels of red blood cells. If you experience symptoms of reduced red blood cell count (anemia) such as shortness of breath, feeling unusually tired, or pale skin, contact your doctor as soon as possible.

Your doctor will do blood tests regularly to monitor the number of specific types of blood cells, including red blood cells, in your blood.

Birth control: Ninlaro (Ixazomib) can cause harm to the developing baby if it is taken by the mother while she is pregnant. If you or your partner are taking Ninlaro (Ixazomib) and may become pregnant, it is important to use 2 effective types of birth control. Oral contraceptives (birth control pills) are not enough, as the effectiveness of birth control pills may be decreased by medications in this cancer treatment. Both males and females should use effective birth control during treatment and for at least 90 days after stopping treatment.

Blood clotting: Ninlaro (Ixazomib) can reduce the number of platelet cells in the blood. Platelets help the blood to clot, and a shortage could make you bleed more easily. Tell your doctor about any signs that your blood is not clotting as quickly as usual. Such symptoms may include black and tarry stools, blood in the urine, easy bruising, or cuts that won't stop bleeding.

Your doctor will do blood tests regularly to monitor the number of specific types of blood cells, including platelets, in your blood.

Infection: As well as killing cancer cells, Ninlaro (Ixazomib) can reduce the number of cells that fight infection in the body (white blood cells). If possible, avoid contact with people with contagious infections.

Tell your doctor immediately if you notice signs of an infection, such as fever or chills, severe diarrhea, shortness of breath, prolonged dizziness, headache, stiff neck, weight loss, or listlessness. Your doctor will do blood tests regularly to monitor the number of specific types of blood cells in your blood.

Kidney function: Severe Kidney Disease or reduced kidney function may cause Ninlaro (Ixazomib) to build up in the body, causing side effects. If you have reduced kidney function or kidney disease, discuss with your doctor how Ninlaro (Ixazomib) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Ninlaro (Ixazomib), and whether any special monitoring is needed.

Liver function: Liver disease or reduced liver function may cause Ninlaro (Ixazomib) to build up in the body, causing side effects. If you have liver problems, discuss with your doctor how Ninlaro (Ixazomib) may affect your medical condition, how your medical condition may affect the dosing and effectiveness of Ninlaro (Ixazomib), and whether any special monitoring is needed. Your doctor may want to test your liver function regularly with blood tests while you are taking Ninlaro (Ixazomib).

Ninlaro (Ixazomib) can cause decreased liver function. If you experience symptoms of liver problems such as fatigue, feeling unwell, loss of appetite, nausea, yellowing of the skin or whites of the eyes, dark urine, pale stools, abdominal pain or swelling, and itchy skin, contact your doctor immediately.

Open capsules: The medication contained inside each capsule is very harmful if it is inhaled or touched. It is important to avoid coming into contact with the drug powder. If a capsule is opened accidentally, wear gloves and protective clothing, including a mask, to clean up the spill. Do not crush, chew, or intentionally open any capsules.

Shingles: Shingles is a reactivation of the herpes zoster virus, which is the virus that causes Chickenpox. The virus stays in the nerve cells after chickenpox and can become activated when the body's defense system is not working well. Because Ninlaro (Ixazomib) can reduce the body's ability to fight infection, the risk of developing shingles is increased for people taking Ninlaro (Ixazomib). Talk to your doctor about ways to reduce the chances of developing shingles.

Pregnancy: Ninlaro (Ixazomib) should not be used during pregnancy unless the benefits outweigh the risks. If you become pregnant while taking Ninlaro (Ixazomib), contact your doctor immediately.

Breast-feeding: It is not known if Ninlaro (Ixazomib) passes into breast milk. If you are a breast-feeding mother and are taking Ninlaro (Ixazomib), it may affect your baby. Talk to your doctor about whether you should continue breast-feeding.

Children: The safety and effectiveness of using Ninlaro (Ixazomib) have not been established for children.

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